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View Structure Prediction Details

Protein: lin-23
Organism: Caenorhabditis elegans
Length: 665 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lin-23.

Description E-value Query
Range
Subject
Range
gi|148658115, gi... - gi|148658115|ref|YP_001278320.1| NB-ARC domain-containing protein [Roseiflexus sp. RS-1], gi|1485702...
648.0 [0..3] [661..798]

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Predicted Domain #1
Region A:
Residues: [1-127]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSPHRASTT QQLADLSLTE GEHDEGKPLS IDYLQGHEGL IEEVLKWSEH EQLDFMDKIV  60
   61 HRLSHYQLGK VDNFIRPMLQ RDFISNLPAH LVELILFNVN SDSLKSCEEV STSWRCALAR 120
  121 GQHWKKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1n6dA
Description: Tricorn protease; Tricorn protease N-terminal domain; Tricorn protease domain 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 1.29702012649067 bayes_pls_golite062009
peptidase activity 0.990550688241572 bayes_pls_golite062009
catalytic activity 0.60409960326459 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [128-665]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEKNVRSDSL WWGLSEKRQW DKFLNISRDM SVRRICEKFN YDVNIKRDKL DQLILMHVFY  60
   61 SKLYPKIIRD IHNIDNNWKR GNYKMTRINC QSENSKGVYC LQYDDDKIVS GLRDNTIKIW 120
  121 DRKDYSCSRI LSGHTGSVLC LQYDNRVIIS GSSDATVRVW DVETGECIKT LIHHCEAVLH 180
  181 LRFANGIMVT CSKDRSIAVW DMVSPRDITI RRVLVGHRAA VNVVDFDDRY IVSASGDRTI 240
  241 KVWSMDTLEF VRTLAGHRRG IACLQYRGRL VVSGSSDNTI RLWDIHSGVC LRVLEGHEEL 300
  301 VRCIRFDEKR IVSGAYDGKI KVWDLQAALD PRALSSEICL CSLVQHTGRV FRLQFDDFQI 360
  361 VSSSHDDTIL IWDFLDAPPS GLPSSTNRAT LPELPNQAAV ARAQMLFEMA ARREIERRDR 420
  421 EVVEEPALRP RANAARRHNA DIAAAAAAAE AARGAGDNDE SSSEEDLDRV DQVNNPNVAG 480
  481 PAPPQPHNQN HRRRQPRPEL PVRLMQEMAA FDNMRRQQNN MDHLGGGDVD EEMPDGGP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.522879
Match: 1nr0A
Description: Actin interacting protein 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 7.6976390971701 bayes_pls_golite062009
small conjugating protein ligase activity 7.38724968585043 bayes_pls_golite062009
acid-amino acid ligase activity 6.41826641115519 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 5.36089569430187 bayes_pls_golite062009
actin binding 3.31804728298431 bayes_pls_golite062009
GTPase activity 3.23750443966606 bayes_pls_golite062009
cytoskeletal protein binding 3.1056443224755 bayes_pls_golite062009
2.92359149151424 bayes_pls_golite062009
tubulin binding 2.76945430061825 bayes_pls_golite062009
microtubule binding 2.72684103222924 bayes_pls_golite062009
dynein binding 2.54821997913979 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
RNA binding 2.1927334052131 bayes_pls_golite062009
dynactin binding 1.92897254169098 bayes_pls_golite062009
ligase activity 1.82531515493699 bayes_pls_golite062009
nucleic acid binding 1.63776917287392 bayes_pls_golite062009
G-protein-coupled receptor binding 1.63631972867316 bayes_pls_golite062009
transcription regulator activity 1.56901113625383 bayes_pls_golite062009
actin filament binding 1.5197243426595 bayes_pls_golite062009
protein binding 1.21879977456466 bayes_pls_golite062009
transporter activity 1.21549336905926 bayes_pls_golite062009
receptor activity 1.12819778129653 bayes_pls_golite062009
DNA binding 1.0776875611211 bayes_pls_golite062009
microtubule plus-end binding 1.01166033978052 bayes_pls_golite062009
molecular transducer activity 0.974380908248463 bayes_pls_golite062009
signal transducer activity 0.974380908248463 bayes_pls_golite062009
type 1 angiotensin receptor binding 0.920323565472959 bayes_pls_golite062009
angiotensin receptor binding 0.920323565472959 bayes_pls_golite062009
transcription repressor activity 0.826090766828089 bayes_pls_golite062009
substrate-specific transporter activity 0.734793983890004 bayes_pls_golite062009
snoRNA binding 0.637990433340251 bayes_pls_golite062009
transcription factor activity 0.541665384827041 bayes_pls_golite062009
dynein intermediate chain binding 0.443846546939402 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.426429095658617 bayes_pls_golite062009
kinase activity 0.387572734234845 bayes_pls_golite062009
receptor binding 0.316169754698691 bayes_pls_golite062009
transcription corepressor activity 0.259860754265901 bayes_pls_golite062009
structural molecule activity 0.254012051644049 bayes_pls_golite062009
transcription factor binding 0.244641056034795 bayes_pls_golite062009
protein kinase activity 0.229242350006544 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.226335610368636 bayes_pls_golite062009
hydrolase activity 0.181211933860468 bayes_pls_golite062009
histone binding 0.166694897714113 bayes_pls_golite062009
structural constituent of cytoskeleton 0.118975415284669 bayes_pls_golite062009
transcription cofactor activity 0.0160791658499004 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00585398682921312 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle