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View Structure Prediction Details

Protein: krs-1
Organism: Caenorhabditis elegans
Length: 596 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for krs-1.

Description E-value Query
Range
Subject
Range
krs-1 - lysyl-tRNA synthetase status:Confirmed UniProt:Q22099 protein_id:AAA82396.1
554.0 [0..31] [596..7]

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Predicted Domain #1
Region A:
Residues: [1-596]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIVSHSMLSR SAVSFLRRRS SSFFGTSVFL SQNTREQKRL AKQAKKEQER LEKDAAKLNV  60
   61 AVADAPKVVR EADPSDPQEY FNMRVRMIEA RRAAGDNPFP HKFNVTISLT DFITKYTPLE 120
  121 KEQVVEEIVS VAGRIHSKRE SGSKLVFYDI HGEGTHIQIM ANAKFHTGDV DFVTLHDRIK 180
  181 RGDIVGFTGR ATRTKAGELS LIPNEILQLT PCLHMLPHSH FGLKDKELRF RKRYLDLILN 240
  241 PRVKDNFVIR SKIITFLRRY LDNLGFLEVE TPIMNQIAGG ATAKPFITHH NDLDMNLFLR 300
  301 VAPELYHKML VVGGIDRVYE VGRLFRNEGI DLTHNPEFTT CEFYMAYADY EDVIQLTEDL 360
  361 LSSMVMSIKG TYKIEYHPNG PNTEPVYEVD FTPPFKRVHM YDGLAEKLGA TLPDPSTLHT 420
  421 EEAREVFDKL CRDNNVDCSA PRTTARLLDK LVGEYLESTF ISPTFLIGHP QIMSPLAKWH 480
  481 RSIPGLTERF ELFAVTREIA NAYTELNDPI TQRQRFEQQA KDKDAGDDEA QMIDETFCNA 540
  541 LEYGLPPTGG WGMGIDRLSM ILTDNNNIKE VLLFPAMRPE DGTEKKTDFD APTTLA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 143.0
Match: 1bbuA
Description: Lysyl-tRNA synthetase (LysRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
lysine-tRNA ligase activity 11.0047124677093 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 7.89468709683036 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 7.89468709683036 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 7.88410036819636 bayes_pls_golite062009
ligase activity 6.92073480193262 bayes_pls_golite062009
asparagine-tRNA ligase activity 5.29805946490109 bayes_pls_golite062009
aspartate-tRNA ligase activity 3.80084837437429 bayes_pls_golite062009
phenylalanine-tRNA ligase activity 3.4145644216516 bayes_pls_golite062009
structural constituent of ribosome 2.90150581291897 bayes_pls_golite062009
glycine-tRNA ligase activity 2.61548498770105 bayes_pls_golite062009
structural molecule activity 2.54582212334303 bayes_pls_golite062009
proline-tRNA ligase activity 2.52223115725965 bayes_pls_golite062009
serine-tRNA ligase activity 2.46505535069103 bayes_pls_golite062009
threonine-tRNA ligase activity 2.18642354927 bayes_pls_golite062009
catalytic activity 1.99372273395202 bayes_pls_golite062009
alanine-tRNA ligase activity 1.82594054955281 bayes_pls_golite062009
histidine-tRNA ligase activity 1.72215103383322 bayes_pls_golite062009
transcription regulator activity 1.67362693618722 bayes_pls_golite062009
binding 1.54403712698597 bayes_pls_golite062009
nucleic acid binding 1.48056625237411 bayes_pls_golite062009
DNA binding 1.44496421928708 bayes_pls_golite062009
translation initiation factor activity 1.27539679024898 bayes_pls_golite062009
transcription factor activity 0.825973629967327 bayes_pls_golite062009
sequence-specific DNA binding 0.77755643935497 bayes_pls_golite062009
ribonuclease activity 0.702449673647117 bayes_pls_golite062009
nuclease activity 0.29926900436997 bayes_pls_golite062009

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