| Protein: | lin-18 |
| Organism: | Caenorhabditis elegans |
| Length: | 562 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lin-18.
| Description | E-value | Query Range |
Subject Range |
|
|
371.0 | [0..3] | [558..385] |
|
Region A: Residues: [1-79] |
1 11 21 31 41 51
| | | | | |
1 MFISKEEMNR TFGVKAELNY IEMGNVSSYS TKFHYRVMAN IDYLSFTWNA VGIVHYEVYV 60
61 ESDDSSVLPI VRIPLKGTV
|
| Detection Method: |  |
| Confidence: | 17.69897 |
| Match: | 1x5lA |
| Description: | Solution structure of the second fn3 domain of Eph receptor A8 protein |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| PTB domain binding | 7.59954514905135 | bayes_pls_golite062009 |
| cytokine receptor activity | 6.1064338595335 | bayes_pls_golite062009 |
| insulin receptor activity | 5.32497038633998 | bayes_pls_golite062009 |
| ciliary neurotrophic factor receptor activity | 5.11860004897785 | bayes_pls_golite062009 |
| interleukin-6 binding | 4.92289154730411 | bayes_pls_golite062009 |
| interleukin-6 receptor activity | 4.92289154730411 | bayes_pls_golite062009 |
| transmembrane receptor activity | 4.81256300373074 | bayes_pls_golite062009 |
| receptor activity | 4.66147271961356 | bayes_pls_golite062009 |
| cytokine binding | 4.43581512268554 | bayes_pls_golite062009 |
| growth factor binding | 4.06808996928726 | bayes_pls_golite062009 |
| molecular transducer activity | 3.69234048247377 | bayes_pls_golite062009 |
| signal transducer activity | 3.69234048247377 | bayes_pls_golite062009 |
| protein binding | 3.24522318184038 | bayes_pls_golite062009 |
| oncostatin-M receptor activity | 3.21526092940028 | bayes_pls_golite062009 |
| leukemia inhibitory factor receptor activity | 3.21526092940028 | bayes_pls_golite062009 |
| binding | 3.12471204223368 | bayes_pls_golite062009 |
| SH2 domain binding | 3.02533711127154 | bayes_pls_golite062009 |
| peptide hormone binding | 3.00179150648816 | bayes_pls_golite062009 |
| ciliary neurotrophic factor receptor binding | 2.93858020991812 | bayes_pls_golite062009 |
| ciliary neurotrophic factor binding | 2.91569341552992 | bayes_pls_golite062009 |
| cytokine receptor binding | 2.64284554734326 | bayes_pls_golite062009 |
| interleukin-11 receptor activity | 2.34894404420874 | bayes_pls_golite062009 |
| interleukin-11 binding | 2.34894404420874 | bayes_pls_golite062009 |
| transcription regulator activity | 2.25224014924603 | bayes_pls_golite062009 |
| growth hormone receptor activity | 2.20449493522 | bayes_pls_golite062009 |
| prolactin receptor activity | 2.15346920063421 | bayes_pls_golite062009 |
| nucleic acid binding | 2.13821456373219 | bayes_pls_golite062009 |
| peptide binding | 2.04467673245315 | bayes_pls_golite062009 |
| axon guidance receptor activity | 2.01367445237355 | bayes_pls_golite062009 |
| DNA binding | 1.95396591505956 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 1.91712452737778 | bayes_pls_golite062009 |
| transcription activator activity | 1.72598380808039 | bayes_pls_golite062009 |
| polysaccharide binding | 1.69642470905172 | bayes_pls_golite062009 |
| interleukin-2 binding | 1.67132604890013 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 1.6158868405814 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.61421027298524 | bayes_pls_golite062009 |
| kinase activity | 1.57994485110649 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.44501485815273 | bayes_pls_golite062009 |
| protein kinase activity | 1.42856560840953 | bayes_pls_golite062009 |
| insulin binding | 1.40490582483684 | bayes_pls_golite062009 |
| heparin binding | 1.40418056272895 | bayes_pls_golite062009 |
| receptor binding | 1.31676259534833 | bayes_pls_golite062009 |
| hormone binding | 1.31120662451488 | bayes_pls_golite062009 |
| transcription factor activity | 1.20939978283833 | bayes_pls_golite062009 |
| transferase activity | 1.13635878582843 | bayes_pls_golite062009 |
| cell surface binding | 1.05599555585797 | bayes_pls_golite062009 |
| mercury ion binding | 1.02618624913674 | bayes_pls_golite062009 |
| protein dimerization activity | 0.86564366658585 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.703490254739121 | bayes_pls_golite062009 |
| structural constituent of muscle | 0.68515307569834 | bayes_pls_golite062009 |
| kinase binding | 0.65927255037265 | bayes_pls_golite062009 |
| enzyme binding | 0.60195860585095 | bayes_pls_golite062009 |
| identical protein binding | 0.564711394496051 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 0.554350228628563 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 0.46168925186147 | bayes_pls_golite062009 |
| transcription factor binding | 0.428445565158989 | bayes_pls_golite062009 |
| protein kinase binding | 0.405060010394646 | bayes_pls_golite062009 |
| cytokine activity | 0.30745438910441 | bayes_pls_golite062009 |
| peptidase activator activity | 0.249363133780499 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.211855991357483 | bayes_pls_golite062009 |
| structural molecule activity | 0.18965275490219 | bayes_pls_golite062009 |
| pattern binding | 0.16768253393396 | bayes_pls_golite062009 |
| protein heterodimerization activity | 0.1430595594485 | bayes_pls_golite062009 |
| protein homodimerization activity | 0.116391819218123 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.116377273702831 | bayes_pls_golite062009 |
| interleukin-2 receptor activity | 0.115337814289139 | bayes_pls_golite062009 |
| transcription coactivator activity | 0.05634414824449 | bayes_pls_golite062009 |
| growth factor activity | 0.0477008672713168 | bayes_pls_golite062009 |
|
Region A: Residues: [80-562] |
1 11 21 31 41 51
| | | | | |
1 PESLQDFTVE YRCAGHRSGQ FAVSLYFTFK YGNKEPLKVK LRQEKICASR DGRRGLNGGY 60
61 EGHEVDDTDS IDKAFFVIIC IAAAFLLIVA ATLICYFKRS KKEDMIPTRL PTSFRNSLKS 120
121 TKSAQPFLLS TPRDGPPTLS AISSAPCSSS SASGNSIIPS KPRNIDVRRA LLQLYQDRDA 180
181 FQSLPLDMEG TFGEVRYAIW RQVDDVLNGD VDDEEDTFCN QEAVYTKTLK NNASPIQLDR 240
241 FLSDALLFYN ITPHQNLSQV ACVASFGRFD RPETVTDFPL VCYRHQGFGN LKKFLTICRH 300
301 GDKTKGAQTL RTHQLVSLAT QVSSAVAHIH KYRIVHNDIA ARNCLIAEVN GRLQVQLCDS 360
361 ALSRDLFPAD YHCLGDNENR PLKWMSPEAI ANELYSSAAD VWSLGVLLWE LMSLGGSPHA 420
421 EIDPEEVYTM ILKGKRLQQP NNCPDQLYEV MLCCWRVLSE DRPSSEQVVH GLRDFNIQLS 480
481 QYI
|
| Detection Method: | |
| Confidence: | 77.0 |
| Match: | 2ptkA |
| Description: | CHICKEN SRC TYROSINE KINASE |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| PTB domain binding | 8.10304453468842 | bayes_pls_golite062009 |
| insulin receptor activity | 6.0833679870912 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 5.49988294224815 | bayes_pls_golite062009 |
| protein kinase activity | 5.4586557943719 | bayes_pls_golite062009 |
| kinase activity | 5.3287080791198 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.96052051118534 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| fibroblast growth factor 1 binding | 4.09909681656699 | bayes_pls_golite062009 |
| transferase activity | 3.97138602499442 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 3.43994026029707 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 3.41480681854114 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 3.40140621607334 | bayes_pls_golite062009 |
| insulin-like growth factor I binding | 3.39379474022325 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 3.26784640416242 | bayes_pls_golite062009 |
| transmembrane receptor activity | 3.1965684217331 | bayes_pls_golite062009 |
| SH2 domain binding | 3.03401803018883 | bayes_pls_golite062009 |
| receptor activity | 2.96273889901429 | bayes_pls_golite062009 |
| signal transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| molecular transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 2.8153155526437 | bayes_pls_golite062009 |
| binding | 2.74863538127007 | bayes_pls_golite062009 |
| insulin-like growth factor II binding | 2.74473718307416 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 2.70917101514973 | bayes_pls_golite062009 |
| growth factor binding | 2.61235080252818 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 2.1677218320705 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 2.1677218320705 | bayes_pls_golite062009 |
| receptor signaling protein activity | 2.10379226653669 | bayes_pls_golite062009 |
| insulin binding | 2.0719180171079 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| fibroblast growth factor binding | 1.9011085456623 | bayes_pls_golite062009 |
| molecular adaptor activity | 1.81145713371725 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 1.62657794525303 | bayes_pls_golite062009 |
| SH3/SH2 adaptor activity | 1.59474164216385 | bayes_pls_golite062009 |
| transcription regulator activity | 1.56748951434625 | bayes_pls_golite062009 |
| nucleic acid binding | 1.46547714006072 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 1.42275431028856 | bayes_pls_golite062009 |
| DNA binding | 1.35333135345112 | bayes_pls_golite062009 |
| kinase binding | 1.26086833316556 | bayes_pls_golite062009 |
| ErbB-3 class receptor binding | 1.25765701903393 | bayes_pls_golite062009 |
| epidermal growth factor receptor binding | 1.24312972088703 | bayes_pls_golite062009 |
| activin binding | 1.22461306010416 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| transporter activity | 1.11833481501707 | bayes_pls_golite062009 |
| transcription factor activity | 1.10928254946881 | bayes_pls_golite062009 |
| protein kinase binding | 1.06030596516506 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase regulator activity | 1.03150090191995 | bayes_pls_golite062009 |
| transcription repressor activity | 1.00304216158732 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.97575992765505 | bayes_pls_golite062009 |
| cytokine receptor binding | 0.966158970381052 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type I | 0.880236579821909 | bayes_pls_golite062009 |
| insulin-like growth factor receptor binding | 0.872782211382796 | bayes_pls_golite062009 |
| transcription activator activity | 0.846644791435606 | bayes_pls_golite062009 |
| protein binding, bridging | 0.83823250804321 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| activin receptor activity | 0.811117252475389 | bayes_pls_golite062009 |
| amine binding | 0.783881819862438 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.705905455086486 | bayes_pls_golite062009 |
| Janus kinase activity | 0.580310109637219 | bayes_pls_golite062009 |
| peptide binding | 0.560033905645957 | bayes_pls_golite062009 |
| ErbB-2 class receptor binding | 0.547121592096699 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 0.499492353295369 | bayes_pls_golite062009 |
| protein serine/threonine/tyrosine kinase activity | 0.48345772948903 | bayes_pls_golite062009 |
| enzyme binding | 0.46284745266176 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.450699332958421 | bayes_pls_golite062009 |
| protein kinase C activity | 0.41587987561486 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| 3-phosphoinositide-dependent protein kinase binding | 0.372842462336059 | bayes_pls_golite062009 |
| MAP kinase kinase kinase activity | 0.37115026509016 | bayes_pls_golite062009 |
| peptide hormone binding | 0.312169974523858 | bayes_pls_golite062009 |
| phosphotyrosine binding | 0.311079584914389 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 0.294256794094724 | bayes_pls_golite062009 |
| transforming growth factor beta binding | 0.287757704969289 | bayes_pls_golite062009 |
| insulin receptor binding | 0.266450215230107 | bayes_pls_golite062009 |
| protein complex binding | 0.239339759110451 | bayes_pls_golite062009 |
| polysaccharide binding | 0.229808864843639 | bayes_pls_golite062009 |
| cytokine binding | 0.17817111033393 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 0.148194101970458 | bayes_pls_golite062009 |
| activin receptor activity, type I | 0.117759584117941 | bayes_pls_golite062009 |
| nitric-oxide synthase regulator activity | 0.00407218246327123 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0040394359628233 | bayes_pls_golite062009 |
