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View Structure Prediction Details

Protein: pab-1
Organism: Caenorhabditis elegans
Length: 646 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pab-1.

Description E-value Query
Range
Subject
Range
gi|73976793 - gi|73976793|ref|XP_857617.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 1 ...
548.0 [0..23] [646..2]

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Predicted Domain #1
Region A:
Residues: [1-211]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEMNVAAPAA AVAGAAAPQP GQNQTGSSYT MASLYVGDLH PDVNESILFE KFSAAGPVLS  60
   61 IRVCRDNATR LSLGYAYVNF QQPADAERAM DTMNFEALHG KPMRIMWSQR DPAMRRSGAG 120
  121 NIFIKNLDKV IDNKSIYDTF SLFGNILSCK VAIDEDGFSK GYGFVHFETE EAAQNAIQKV 180
  181 NGMLLAGKKV FVGKFQPRAQ RNRELGETAK Q

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.221849
Match: 1cvjA
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
snRNA binding 4.06596327298973 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
U1 snRNA binding 3.02511982045347 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.98418556946403 bayes_pls_golite062009
structural molecule activity 1.56454315220334 bayes_pls_golite062009
U2 snRNA binding 1.34078165372485 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 1.07843408116687 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [212-307]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTNVYVKNFG DHYNKETLEK LFAKFGNITS CEVMTVEGKS KGFGFVAFAN PEEAETAVQA  60
   61 LHDSTIEGTD LKLHVCRAQK KSERHAELKK KHEQHK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.522879
Match: 2disA
Description: No description for 2disA was found.

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
snRNA binding 4.06596327298973 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
U1 snRNA binding 3.02511982045347 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.98418556946403 bayes_pls_golite062009
structural molecule activity 1.56454315220334 bayes_pls_golite062009
U2 snRNA binding 1.34078165372485 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 1.07843408116687 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [308-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AERMQKYQGV NLYVKNLDET VDDDGLKKQF ESYGNITSAK VMTDENGRSK GFGFVCFEKP  60
   61 EEATSAVTEM NSKMVCSKPL YVAIAQR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.41
Match: 2f3jA
Description: No description for 2f3jA was found.

Predicted Domain #4
Region A:
Residues: [395-504]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEDRRAQLAS QYMQRLASMR MHGNVPGAAM YNPTQPGPGY YVANPMQQQR NFAGGQQMVR  60
   61 PGGRWGMQNQ YPVQNQYMMA QGPGVYQNRM GRPQNQQGGP RGPPQQYNQV 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [505-646]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQGGVRMQGP PRTQNPGVQQ QNVPRPPQQQ QQQRPAPTGP KAPPQPYQAY QQRPQGIVIG  60
   61 GQEPLTSAML AAAAPQEQKQ LLGERIYALI EKLYPGHKDA GKITGMMLEI DNSELIMMLQ 120
  121 DSELFRSKVD EAASVLVSAQ KQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.39794
Match: 1g9lA
Description: poly(A) binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.69788763665792 bayes_pls_golite062009
mRNA binding 5.31297072316889 bayes_pls_golite062009
single-stranded RNA binding 4.51056428709072 bayes_pls_golite062009
nucleic acid binding 3.78909647605682 bayes_pls_golite062009
eukaryotic initiation factor 4G binding 3.4111148675327 bayes_pls_golite062009
binding 2.76167454154417 bayes_pls_golite062009
poly(A) RNA binding 2.66269581586161 bayes_pls_golite062009
poly-purine tract binding 2.20136693536924 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.19350242454642 bayes_pls_golite062009
small conjugating protein ligase activity 1.14692713780316 bayes_pls_golite062009
protein binding 0.856075580719879 bayes_pls_golite062009
catalytic activity 0.287695754348243 bayes_pls_golite062009
acid-amino acid ligase activity 0.223805219849164 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle