YRC Public Data Repository - Protein Structure Prediction

Protein:	sar-1
Organism:	Caenorhabditis elegans
Length:	193 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sar-1.

Description	E-value	Query Range	Subject Range
gi\|34909214, gi\|... - gi\|34909214\|ref\|NP_915954.1\| putative ADP-ribosylation factor [Oryza sativa (japonica cultivar-group...	173.0	[0..1]	[193..179]
gi\|48109763, gi\|... - gi\|66532753\|ref\|XP_623373.1\| PREDICTED: similar to sar1 CG7073-PA, isoform A isoform 2 [Apis mellife...	173.0	[0..3]	[193..2]
gi\|50738954 - gi\|50738954\|ref\|XP_419342.1\| PREDICTED: similar to ras-related protein [Gallus gallus]	172.0	[0..22]	[193..200]
gi\|108873845, gi... - gi\|94468896\|gb\|ABF18297.1\| vesicle coat complex COPII GTPase subunit SAR1 [Aedes aegypti], gi\|15712...	171.0	[0..3]	[193..2]
sar1-PD, sar1-PC... - The gene sar1 is referred to in FlyBase by the symbol Dmel\sar1 (CG7073, FBgn0038947). It is a prote... gi\|54638516, gi\|... - gi\|54638516\|gb\|EAL27918.1\| GA20080 [Drosophila pseudoobscura pseudoobscura], gi\|125775047\|ref\|XP_001... gi\|54638516\|gb\|E... - GA20080-PA [Drosophila pseudoobscura], GA20080 [Drosophila pseudoobscura pseudoobscura] gi\|195330967, gi... - gi\|195330967\|ref\|XP_002032174.1\| GM26415 [Drosophila sechellia], gi\|194121117\|gb\|EDW43160.1\| GM26415... gi\|194743116, gi... - gi\|194743116\|ref\|XP_001954046.1\| GF18079 [Drosophila ananassae], gi\|190627083\|gb\|EDV42607.1\| GF18079... gi\|195572826, gi... - gi\|195572826\|ref\|XP_002104396.1\| GD20936 [Drosophila simulans], gi\|194200323\|gb\|EDX13899.1\| GD20936 ... gi\|195502531, gi... - gi\|195502531\|ref\|XP_002098265.1\| GE10286 [Drosophila yakuba], gi\|194184366\|gb\|EDW97977.1\| GE10286 [D... gi\|220959418, gi... - gi\|220959418\|gb\|ACL92252.1\| sar1-PA [synthetic construct], gi\|220950500\|gb\|ACL87793.1\| sar1-PA [synt...	171.0	[0..3]	[193..2]
rab-1 - RAS-related protein status:Confirmed UniProt:Q9UAQ6 protein_id:AAC69218.1	170.0	[0..22]	[193..12]
CRE16067, FL81_1... - RP15185 WBGene00061078 locus:Cre-rab-1 status:Confirmed, null gi\|157761211 - gi\|157761211\|ref\|XP_001672948.1\| Hypothetical protein CBG01077 [Caenorhabditis briggsae AF16] gi\|39588485, gi\|... - gi\|39588485\|emb\|CAE58008.1\| Hypothetical protein CBG01077 [Caenorhabditis briggsae], gi\|187038224\|em...	170.0	[0..22]	[193..12]
gi\|91091500 - gi\|91091500\|ref\|XP_968802.1\| PREDICTED: similar to AGAP004098-PA [Tribolium castaneum]	169.0	[0..3]	[193..2]
gi\|62948008 - gi\|62948008\|gb\|AAY23007.1\| GTP-binding protein SAR1b [Sus scrofa]	168.0	[0..1]	[193..1]

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Predicted Domain #1

Region A:
Residues: [1-193]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFLWDWFNG VLNMLGLANK KGKLVFLGLD NAGKTTLLHM LKDDRIAQHV PTLHPTSEQM  60
   61 SLGGISFTTY DLGGHAQARR VWKDYFPAVD AVVFLIDVAD AERMQESRVE LESLLQDEQI 120
  121 ASVPVLILGN KIDKPGALSE DQLKWQLNIQ HMCTGKGDVS RNEMASRPME VFMCSVLQRQ 180
  181 GYGEGIRWLG QYL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	41.522879
Match:	1f6bA
Description:	SAR1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
microtubule motor activity	4.51968578934603	bayes_pls_golite062009
motor activity	4.04927796049806	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
tubulin binding	2.67743463093593	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
primary active transmembrane transporter activity	2.61775212528604	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.61467977505707	bayes_pls_golite062009
microtubule binding	2.59155206524122	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.57552435627908	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.57107347424517	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.57054427875021	bayes_pls_golite062009
NAD(P)+-protein-arginine ADP-ribosyltransferase activity	2.56769246638533	bayes_pls_golite062009
microfilament motor activity	2.51786963027655	bayes_pls_golite062009
active transmembrane transporter activity	2.50494515048649	bayes_pls_golite062009
ATPase activity, coupled	2.43862163407966	bayes_pls_golite062009
cytoskeletal protein binding	2.4101693596493	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
actin binding	2.2973522188675	bayes_pls_golite062009
amine transmembrane transporter activity	2.29486577878686	bayes_pls_golite062009
nucleic acid binding	2.09956015274464	bayes_pls_golite062009
transcription regulator activity	2.09345198747025	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
guanyl nucleotide binding	1.89320355239381	bayes_pls_golite062009
guanyl ribonucleotide binding	1.88721318481223	bayes_pls_golite062009
GTP binding	1.87900088157196	bayes_pls_golite062009
DNA binding	1.87765278833074	bayes_pls_golite062009
organic acid transmembrane transporter activity	1.77111739879769	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	1.75695995185278	bayes_pls_golite062009
protein transporter activity	1.71214667007262	bayes_pls_golite062009
GTPase activity	1.6309422514633	bayes_pls_golite062009
hydrolase activity	1.57549510726226	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.56325751172863	bayes_pls_golite062009
signal recognition particle binding	1.46975774710831	bayes_pls_golite062009
plus-end-directed microtubule motor activity	1.38366133153678	bayes_pls_golite062009
microtubule plus-end binding	1.36713729043205	bayes_pls_golite062009
actin filament binding	1.28204719195916	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
RNA helicase activity	1.02424782546779	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
ATP binding	0.98146619596929	bayes_pls_golite062009
ion transmembrane transporter activity	0.977237423302079	bayes_pls_golite062009
RNA-dependent ATPase activity	0.95986988363392	bayes_pls_golite062009
adenyl ribonucleotide binding	0.949788783884952	bayes_pls_golite062009
ATP-dependent RNA helicase activity	0.94128341275411	bayes_pls_golite062009
adenyl nucleotide binding	0.931486373329219	bayes_pls_golite062009
purine nucleotide binding	0.929901285538132	bayes_pls_golite062009
nucleotide binding	0.922442819194247	bayes_pls_golite062009
actin-dependent ATPase activity	0.92105578610354	bayes_pls_golite062009
purine ribonucleotide binding	0.920987930180051	bayes_pls_golite062009
ribonucleotide binding	0.920926158369519	bayes_pls_golite062009
kinase activity	0.691112783105676	bayes_pls_golite062009
molecular transducer activity	0.683309012097319	bayes_pls_golite062009
signal transducer activity	0.683309012097319	bayes_pls_golite062009
transcription factor activity	0.682439846757997	bayes_pls_golite062009
transmembrane receptor activity	0.661834961742057	bayes_pls_golite062009
receptor activity	0.633514002718998	bayes_pls_golite062009
amino acid transmembrane transporter activity	0.585668369219566	bayes_pls_golite062009
cation transmembrane transporter activity	0.557919489256916	bayes_pls_golite062009
ribonucleoprotein binding	0.53788302029845	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.499834566483656	bayes_pls_golite062009
drug transmembrane transporter activity	0.38711726712063	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	0.305627755818843	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	0.213018989352421	bayes_pls_golite062009
structural constituent of ribosome	0.208665086324262	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.123304946374679	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009
cell surface binding	0.0454774504404609	bayes_pls_golite062009
structural constituent of muscle	0.0436357112276422	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.0430764033739892	bayes_pls_golite062009
protein kinase activity	0.0364322017534667	bayes_pls_golite062009
structural constituent of cytoskeleton	0.0111338193708552	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: