YRC Public Data Repository - Protein Structure Prediction

Protein:	nth-1
Organism:	Caenorhabditis elegans
Length:	259 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nth-1.

Description	E-value	Query Range	Subject Range
gi\|68546031, gi\|... - gi\|68546031\|ref\|ZP_00585580.1\| A/G-specific adenine glycosylase MutY [Shewanella amazonensis SB2B], ...	256.0	[0..8]	[255..216]
gi\|75819192, gi\|... - gi\|75819192\|ref\|ZP_00749285.1\| COG1194: A/G-specific DNA glycosylase [Vibrio cholerae V51], gi\|11621...	253.0	[0..7]	[253..23]
gi\|116189574, gi... - gi\|75829107\|ref\|ZP_00758424.1\| COG1194: A/G-specific DNA glycosylase [Vibrio cholerae MO10], gi\|1161...	253.0	[0..7]	[253..23]
gi\|53753706, gi\|... - gi\|54293874\|ref\|YP_126289.1\| hypothetical protein lpl0930 [Legionella pneumophila str. Lens], gi\|537...	251.0	[0..8]	[251..14]
gi\|75822032, gi\|... - gi\|75822032\|ref\|ZP_00751746.1\| COG1194: A/G-specific DNA glycosylase [Vibrio cholerae RC385], gi\|116...	251.0	[0..7]	[253..23]
Q666M4\|Q666M4_YERPS - A/G-specific adenine glycosylase. - Yersinia pseudotuberculosis gi\|51590816, gi\|... - gi\|51597534\|ref\|YP_071725.1\| adenine DNA glycosylase [Yersinia pseudotuberculosis IP 32953], gi\|5159...	251.0	[0..8]	[256..10]
gi\|78504971, gi\|... - gi\|78687322\|ref\|ZP_00852074.1\| A/G-specific adenine glycosylase MutY [Shewanella sp. ANA-3], gi\|7850...	251.0	[0..8]	[251..11]
gi\|22127215, gi\|... - gi\|22127215\|ref\|NP_670638.1\| adenine DNA glycosylase [Yersinia pestis KIM], gi\|21960283\|gb\|AAM86889.... gi\|45443228, gi\|... - gi\|45443228\|ref\|NP_994767.1\| adenine DNA glycosylase [Yersinia pestis biovar Microtus str. 91001], g...	250.0	[0..8]	[256..54]
gi\|167421991, gi... - gi\|167421991\|ref\|ZP_02313744.1\| A/G-specific adenine glycosylase [Yersinia pestis biovar Orientalis ... gi\|167050802, gi... - gi\|167400094\|ref\|ZP_02305612.1\| A/G-specific adenine glycosylase [Yersinia pestis biovar Antiqua str... gi\|166206169, gi... - gi\|166212877\|ref\|ZP_02238912.1\| A/G-specific adenine glycosylase [Yersinia pestis biovar Antiqua str... gi\|165990761, gi... - gi\|166010275\|ref\|ZP_02231173.1\| A/G-specific adenine glycosylase [Yersinia pestis biovar Antiqua str... gi\|167426696, gi... - gi\|167426696\|ref\|ZP_02318449.1\| A/G-specific adenine glycosylase [Yersinia pestis biovar Mediaevalis... gi\|108813310, gi... - gi\|108813310\|ref\|YP_649077.1\| adenine DNA glycosylase [Yersinia pestis Nepal516], gi\|108776958\|gb\|AB... gi\|145597869, gi... - gi\|145597869\|ref\|YP_001161945.1\| adenine DNA glycosylase [Yersinia pestis Pestoides F], gi\|145209565... gi\|108806309, gi... - gi\|108806309\|ref\|YP_650225.1\| adenine DNA glycosylase [Yersinia pestis Antiqua], gi\|108778222\|gb\|ABG... gi\|165914809, gi... - gi\|89102125\|ref\|ZP_01174785.1\| COG1194: A/G-specific DNA glycosylase [Yersinia pestis biovar Orienta... gi\|165925102, gi... - gi\|165925102\|ref\|ZP_02220934.1\| A/G-specific adenine glycosylase [Yersinia pestis biovar Orientalis ...	250.0	[0..8]	[256..11]
gi\|229903773, gi... - gi\|229903773\|ref\|ZP_04518886.1\| adenine DNA glycosylase [Yersinia pestis Nepal516], gi\|229679543\|gb\|... gi\|15979021, gi\|... - gi\|218928123\|ref\|YP_002345998.1\| adenine DNA glycosylase [Yersinia pestis CO92], gi\|16121255\|ref\|NP_... gi\|25292160 - pir\|\|AH0116 A/G-specific adenine glycosylase (EC 3.2.2.-) [imported] - Yersinia pestis (strain CO92) gi\|149290654, gi... - gi\|149367040\|ref\|ZP_01889073.1\| A/G-specific adenine glycosylase [Yersinia pestis CA88-4125], gi\|149... gi\|229837648, gi... - gi\|229837648\|ref\|ZP_04457810.1\| adenine DNA glycosylase [Yersinia pestis Pestoides A], gi\|229704336\|... gi\|229842567, gi... - gi\|229842567\|ref\|ZP_04462722.1\| adenine DNA glycosylase [Yersinia pestis biovar Orientalis str. Indi... gi\|229697238, gi... - gi\|229840872\|ref\|ZP_04461031.1\| adenine DNA glycosylase [Yersinia pestis biovar Orientalis str. PEXU...	250.0	[0..8]	[256..10]

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Predicted Domain #1

Region A:
Residues: [1-259]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKDMIAPVD TMGCHKLADP LAAPPVHRFQ VLVALMLSSQ TRDEVNAAAM KRLKDHGLSI  60
   61 GKILEFKVPD LETILCPVGF YKRKAVYLQK TAKILKDDFS GDIPDSLDGL CALPGVGPKM 120
  121 ANLVMQIAWG ECVGIAVDTH VHRISNRLGW IKTSTPEKTQ KALEILLPKS EWQPINHLLV 180
  181 GFGQMQCQPV RPKCGTCLCR FTCPSSTAKN VKSETEETST SIEVKQEVED EFEDEKPAKK 240
  241 IKKTRKTRTK IEVKTESET

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	59.69897
Match:	2abkA
Description:	REFINEMENT OF THE NATIVE STRUCTURE OF ENDONUCLEASE III TO A RESOLUTION OF 1.85 ANGSTROM
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA N-glycosylase activity	4.08559331236111	bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds	3.73234184319832	bayes_pls_golite062009
DNA-(apurinic or apyrimidinic site) lyase activity	3.12421941323765	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	2.54759386266723	bayes_pls_golite062009
catalytic activity	2.50389926428623	bayes_pls_golite062009
oxidized base lesion DNA N-glycosylase activity	1.80199518353554	bayes_pls_golite062009
alkylbase DNA N-glycosylase activity	1.75218522602775	bayes_pls_golite062009
hydrolase activity	1.39000450534744	bayes_pls_golite062009
DNA-3-methyladenine glycosylase I activity	1.14337995879633	bayes_pls_golite062009
oxidized purine base lesion DNA N-glycosylase activity	0.473206156100251	bayes_pls_golite062009
uracil DNA N-glycosylase activity	0.29478804124408	bayes_pls_golite062009
oxidized pyrimidine base lesion DNA N-glycosylase activity	0.253198605718519	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: