YRC Public Data Repository - Protein Structure Prediction

Protein:	uev-2
Organism:	Caenorhabditis elegans
Length:	230 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for uev-2.

Description	E-value	Query Range	Subject Range
gi\|62738886 - gi\|62738886\|pdb\|1Z2U\|A Chain A, The 1.1a Crystallographic Structure Of Ubiquitin- Conjugating Enzyme...	197.0	[0..33]	[185..2]
gi\|109066782 - gi\|109066782\|ref\|XP_001096263.1\| PREDICTED: similar to ubiquitin-conjugating enzyme E2D 4 (putative)... gi\|114613001, gi... - gi\|114613001\|ref\|XP_519070.2\| PREDICTED: ubiquitin-conjugating enzyme E2D 4 (putative) isoform 4 [Pa... UBE2D4 - ubiquitin-conjugating enzyme E2D 4 (putative)	196.0	[0..35]	[185..1]
gi\|48095652, gi\|... - ref\|XP_392337.1\| similar to Ubiquitin-conjugating enzyme E2-17 kDa (Ubiquitin-protein ligase) (Ubiqu...	195.0	[0..35]	[185..1]
gi\|37590333, gi\|... - gi\|41152425\|ref\|NP_955958.1\| ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) [Danio rerio...	195.0	[0..35]	[185..1]
gi\|116487484, gi... - gi\|118404876\|ref\|NP_001072891.1\| ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog) [Xenopus (Silur... gi\|54311502, gi\|... - gi\|54311502\|gb\|AAH84849.1\| LOC495381 protein [Xenopus laevis], gi\|49899030\|gb\|AAH76728.1\| Ube2d2-pro...	194.0	[0..35]	[185..1]
gi\|87239726 - gi\|87239726\|emb\|CAJ57642.1\| putative ubiquitin conjugating enzyme 2 [Oesophagostomum dentatum]	194.0	[0..35]	[185..1]
gi\|11762186 - gi\|11762186\|gb\|AAG40371.1\|AF325019_1 AT4g27960 [Arabidopsis thaliana]	194.0	[0..20]	[186..16]
gi\|220955014, gi... - gi\|220955014\|gb\|ACL90050.1\| eff-PA [synthetic construct], gi\|220945198\|gb\|ACL85142.1\| eff-PA [synthe... gi\|239791033, gi... - gi\|89473748\|gb\|ABD72686.1\| putative ubiquitin-conjugating enzyme [Acyrthosiphon pisum], gi\|239791033... eff-PA, FBpp0302... - The gene effete is referred to in FlyBase by the symbol Dmel\eff (CG7425, FBgn0011217). It is a prot... gi\|194101853, gi... - gi\|195143851\|ref\|XP_002012910.1\| GL23670 [Drosophila persimilis], gi\|194101853\|gb\|EDW23896.1\| GL2367... gi\|195113175, gi... - gi\|195113175\|ref\|XP_002001144.1\| GI10619 [Drosophila mojavensis], gi\|193917738\|gb\|EDW16605.1\| GI1061... gi\|195390905, gi... - gi\|195390905\|ref\|XP_002054107.1\| GJ22971 [Drosophila virilis], gi\|194152193\|gb\|EDW67627.1\| GJ22971 [... gi\|194120107, gi... - gi\|195328929\|ref\|XP_002031164.1\| GM25828 [Drosophila sechellia], gi\|194120107\|gb\|EDW42150.1\| GM25828... gi\|46561756 - gi\|46561756\|gb\|AAT01083.1\| putative ubiquitin-conjugating enzyme [Homalodisca coagulata] gi\|91077526 - gi\|91077526\|ref\|XP_970430.1\| PREDICTED: similar to Ubiquitin-conjugating enzyme E2-17 kDa (Ubiquitin... gi\|195501528, gi... - gi\|195501528\|ref\|XP_002097834.1\| eff [Drosophila yakuba], gi\|194183935\|gb\|EDW97546.1\| eff [Drosophil... gi\|55243675, gi\|... - gi\|58381090\|ref\|XP_310998.2\| AGAP000145-PA [Anopheles gambiae str. PEST], gi\|55243675\|gb\|EAA06420.3\|... gi\|157134117, gi... - gi\|94468952\|gb\|ABF18325.1\| ubiquitin-conjugating enzyme [Aedes aegypti], gi\|157134117\|ref\|XP_0016631... gi\|195444200, gi... - gi\|195444200\|ref\|XP_002069759.1\| GK11688 [Drosophila willistoni], gi\|194165844\|gb\|EDW80745.1\| GK1168... gi\|198131302, gi... - gi\|198451027\|ref\|XP_002137205.1\| GA26693 [Drosophila pseudoobscura pseudoobscura], gi\|198131302\|gb\|E... gi\|195570846, gi... - gi\|195570846\|ref\|XP_002103415.1\| GD20402 [Drosophila simulans], gi\|194199342\|gb\|EDX12918.1\| GD20402 ... AGAP000145-PA - ubiquitin-conjugating enzyme E2D\|protein_coding\|X:2217741:2226824:-1\|gene:AGAP000145 gi\|156550189 - gi\|156550189\|ref\|XP_001605481.1\| PREDICTED: similar to ubiquitin-conjugating enzyme [Nasonia vitripe... gi\|190627186, gi... - gi\|194743322\|ref\|XP_001954149.1\| GF18131 [Drosophila ananassae], gi\|190627186\|gb\|EDV42710.1\| GF18131... gi\|195061220, gi... - gi\|195061220\|ref\|XP_001995948.1\| GH14086 [Drosophila grimshawi], gi\|193891740\|gb\|EDV90606.1\| GH14086... gi\|190651664, gi... - gi\|194900836\|ref\|XP_001979961.1\| GG21088 [Drosophila erecta], gi\|190651664\|gb\|EDV48919.1\| GG21088 [D...	194.0	[0..35]	[185..1]

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Predicted Domain #1

Region A:
Residues: [1-230]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRRSNRQYV DLSYFRETAD ALLFDVETNS REFTNEINTV KEEKAKWDER TPQGYTAKPI  60
   61 SFEGADIWCS WICTVPGPRG SPWEGGEYEV SVNFHKWPII PPICEFKTPL HHPNVDLRGS 120
  121 IYLKMLEQEH WSSETSLKKL LREISNLLAT PDLTQAANIE AWMEYENQRE NYEAKARAYA 180
  181 WTVNPNAVGY MEVSENSGIQ RETAKAKLAV QNGAMESDED DDDLPIDIEN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	36.69897
Match:	1tteA
Description:	The Structure of a Class II ubiquitin-conjugating enzyme, Ubc1.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	11.3486134076304	bayes_pls_golite062009
small conjugating protein ligase activity	11.2964721480824	bayes_pls_golite062009
acid-amino acid ligase activity	10.2401422444624	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	8.93602533934698	bayes_pls_golite062009
HLH domain binding	8.10904818707269	bayes_pls_golite062009
ligase activity	5.17219147802758	bayes_pls_golite062009
SUMO ligase activity	3.88357560284404	bayes_pls_golite062009
transcription regulator activity	2.21355731489173	bayes_pls_golite062009
nucleic acid binding	2.13970605403492	bayes_pls_golite062009
DNA binding	1.95596447916631	bayes_pls_golite062009
protein binding	1.77678273247394	bayes_pls_golite062009
binding	1.75350658654805	bayes_pls_golite062009
transcription repressor activity	1.5236035191291	bayes_pls_golite062009
catalytic activity	0.891402822028799	bayes_pls_golite062009
NEDD8 ligase activity	0.715654744941217	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.58835335751383	bayes_pls_golite062009
kinase activity	0.519703305315987	bayes_pls_golite062009
protein kinase activity	0.443948654247666	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.373779304908933	bayes_pls_golite062009
protein serine/threonine kinase activity	0.182854082413338	bayes_pls_golite062009
transcription corepressor activity	0.122859425935324	bayes_pls_golite062009
transferase activity	0.0984525836903841	bayes_pls_golite062009
transcription activator activity	0.0138208971172455	bayes_pls_golite062009
transcription factor binding	0.0104967529560147	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: