YRC Public Data Repository - Protein Structure Prediction

Protein:	apc-11
Organism:	Caenorhabditis elegans
Length:	135 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for apc-11.

Description	E-value	Query Range	Subject Range
gi\|157775229 - gi\|157775229\|ref\|XP_001665680.1\| hypothetical protein CBG18032 [Caenorhabditis briggsae AF16] gi\|187025093, gi... - gi\|39591598\|emb\|CAE71175.1\| Hypothetical protein CBG18032 [Caenorhabditis briggsae], gi\|187025093\|em...	99.0	[0..1]	[135..1]
gi\|125549990 - gi\|125549990\|gb\|EAY95812.1\| hypothetical protein OsI_17683 [Oryza sativa Indica Group] HIP1_ORYSJ - Probable E3 ubiquitin-protein ligase HIP1 OS=Oryza sativa subsp. japonica GN=HIP1 PE=1 SV=2	91.0	[0..11]	[128..558]
gi\|116200598, gi... - gi\|88175558\|gb\|EAQ83026.1\| conserved hypothetical protein [Chaetomium globosum CBS 148.51], gi\|11620...	89.0	[0..49]	[132..1]
gi\|1076498, gi\|5... - gi\|558543\|emb\|CAA85320.1\| C-terminal zinc-finger [Glycine max], pir\|\|S49445 RING finger protein Pzf ...	89.0	[0..14]	[135..278]
MBR1_ARATH - E3 ubiquitin-protein ligase MBR1 OS=Arabidopsis thaliana GN=MBR1 PE=1 SV=1	88.0	[0..2]	[130..582]
gi\|159122965 - gi\|159122965\|gb\|EDP48085.1\| anaphase promoting complex subunit Apc11, putative [Aspergillus fumigatu... gi\|66844418, gi\|... - gi\|70982532\|ref\|XP_746794.1\| anaphase promoting complex subunit Apc11 [Aspergillus fumigatus Af293],...	88.0	[0..49]	[131..1]
gi\|558545, gi\|10... - gi\|558545\|emb\|CAA85321.1\| protein containing C-terminal RING-finger [Lotus japonicus], gi\|1771195\|em...	88.0	[0..14]	[135..439]
gi\|4240031 - gi\|4240031\|dbj\|BAA74802.1\| DNA binding zinc finger protein (Pspzf) [Pisum sativum]	87.0	[0..14]	[135..362]
gi\|90299721, gi\|... - gi\|90299721\|gb\|EAS29352.1\| hypothetical protein CIMG_08098 [Coccidioides immitis RS], gi\|119178538\|r...	86.0	[0..49]	[132..1]

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Predicted Domain #1

Region A:
Residues: [1-135]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQQIQMDEQ ENDESQGNDD QQNMSMSSSE LHTMQDDHPG ILLKTNTRMS ITVKKLHVCG  60
   61 EWKWLQGGED TCGICRMEFE SACNMCKFPG DDCPLVLGIC RHAFHRHCID KWIAAPTNQP 120
  121 RAQCPLCRQD WTIVE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.522879
Match:	1u6gB
Description:	Crystal Structure of The Cand1-Cul1-Roc1 Complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	10.2497392096259	bayes_pls_golite062009
small conjugating protein ligase activity	10.0460587929138	bayes_pls_golite062009
acid-amino acid ligase activity	8.99384576623969	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	7.6988425139962	bayes_pls_golite062009
ligase activity	3.92677358871643	bayes_pls_golite062009
binding	2.58862749918018	bayes_pls_golite062009
NEDD8 ligase activity	2.41658628840288	bayes_pls_golite062009
protein binding	1.49775478023418	bayes_pls_golite062009
small conjugating protein-specific protease activity	1.2126425713931	bayes_pls_golite062009
ubiquitin-specific protease activity	1.03469202541773	bayes_pls_golite062009
transcription factor binding	0.90065892745057	bayes_pls_golite062009
transcription regulator activity	0.779340816536763	bayes_pls_golite062009
nucleic acid binding	0.708499177773075	bayes_pls_golite062009
hydrolase activity	0.52386813728704	bayes_pls_golite062009
cysteine-type peptidase activity	0.50197530717959	bayes_pls_golite062009
transcription repressor activity	0.393708074680332	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.392372133643049	bayes_pls_golite062009
ubiquitin thiolesterase activity	0.265769062717221	bayes_pls_golite062009
DNA binding	0.227671243150662	bayes_pls_golite062009
catalytic activity	0.14112008370434	bayes_pls_golite062009
enzyme binding	0.104373352314595	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: