YRC Public Data Repository - Protein Structure Prediction

Protein:	SPCC18.08
Organism:	Schizosaccharomyces pombe
Length:	531 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPCC18.08.

Description	E-value	Query Range	Subject Range
gi\|26250946, gi\|... - gi\|26250946\|ref\|NP_756986.1\| lysyl-tRNA synthetase [Escherichia coli CFT073], gi\|26111378\|gb\|AAN8356... gi\|226901632, gi... - gi\|237703720\|ref\|ZP_04534201.1\| lysyl-tRNA synthetase [Escherichia sp. 3_2_53FAA], gi\|226901632\|gb\|E... gi\|91075253, gi\|... - gi\|91213679\|ref\|YP_543665.1\| lysyl-tRNA synthetase, heat inducible [Escherichia coli UTI89], gi\|9107...	497.0	[0..13]	[530..8]
SYK2_ECO57 - (P0A8N6) Lysyl-tRNA synthetase, heat inducible (EC 6.1.1.6) (Lysine--tRNA ligase) (LysRS) SYK2_ECOLI - (P0A8N5) Lysyl-tRNA synthetase, heat inducible (EC 6.1.1.6) (Lysine--tRNA ligase) (LysRS)	497.0	[0..18]	[530..3]
SYK_SHIDS - Lysine--tRNA ligase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=lysS PE=3 SV=1	496.0	[0..28]	[531..14]
SYK2_ECOLI - Lysyl-tRNA synthetase, heat inducible (EC 6.1.1.6) (Lysine--tRNA ligase) (LysRS) - Escherichia coli SYK2_ECO57 - Lysine--tRNA ligase, heat inducible OS=Escherichia coli O157:H7 GN=lysU PE=3 SV=2 EG10553 - lysine tRNA synthetase, inducible / Lysine--tRNA ligase, heat inducible; Ap4A and Ap3A synthase gi\|15804722, gi\|... - gi\|15804722\|ref\|NP_290763.1\| lysyl-tRNA synthetase [Escherichia coli O157:H7 EDL933], gi\|12519106\|gb... gi\|15834365, gi\|... - gi\|15834365\|ref\|NP_313138.1\| lysyl-tRNA synthetase [Escherichia coli O157:H7 str. Sakai], gi\|1336458... gi\|238861695, gi... - gi\|238903238\|ref\|YP_002929034.1\| lysine tRNA synthetase, inducible [Escherichia coli BW2952], gi\|238... gi\|254796152, gi... - gi\|254796152\|ref\|YP_003080989.1\| lysine tRNA synthetase, inducible [Escherichia coli O157:H7 str. TW... gi\|170083579, gi... - gi\|170083579\|ref\|YP_001732899.1\| lysine tRNA synthetase, inducible [Escherichia coli str. K-12 subst... gi\|189379164, gi... - gi\|189379164\|gb\|EDU97580.1\| lysyl-tRNA synthetase LysU [Escherichia coli O157:H7 str. EC508], gi\|168... gi\|208726904, gi... - gi\|208807103\|ref\|ZP_03249440.1\| lysyl-tRNA synthetase LysU [Escherichia coli O157:H7 str. EC4206], g... EG10553 - lysine tRNA synthetase, inducible / Lysine--tRNA ligase, heat inducible; Ap4A and Ap3A synthase gi\|195935919 - gi\|195935919\|ref\|ZP_03081301.1\| lysyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4024] gi\|208819932, gi... - gi\|208819932\|ref\|ZP_03260252.1\| lysyl-tRNA synthetase LysU [Escherichia coli O157:H7 str. EC4042], g... gi\|208735239, gi... - gi\|208813962\|ref\|ZP_03255291.1\| lysyl-tRNA synthetase LysU [Escherichia coli O157:H7 str. EC4045], g... gi\|209921620, gi... - gi\|209921620\|ref\|YP_002295704.1\| lysyl-tRNA synthetase [Escherichia coli SE11], gi\|209914879\|dbj\|BAG... gi\|209162047, gi... - gi\|209400647\|ref\|YP_002273676.1\| lysyl-tRNA synthetase LysU [Escherichia coli O157:H7 str. EC4115], ... gi\|188017408, gi... - gi\|188017408\|gb\|EDU55530.1\| lysyl-tRNA synthetase LysU [Escherichia coli O157:H7 str. EC4113], gi\|16... gi\|168760993, gi... - gi\|189368520\|gb\|EDU86936.1\| lysyl-tRNA synthetase LysU [Escherichia coli O157:H7 str. EC4501], gi\|16... gi\|168755314, gi... - gi\|189357458\|gb\|EDU75877.1\| lysyl-tRNA synthetase LysU [Escherichia coli O157:H7 str. EC4401], gi\|16... gi\|168774502, gi... - gi\|187769884\|gb\|EDU33728.1\| lysyl-tRNA synthetase LysU [Escherichia coli O157:H7 str. EC4196], gi\|16... gi\|168766403, gi... - gi\|189364021\|gb\|EDU82440.1\| lysyl-tRNA synthetase LysU [Escherichia coli O157:H7 str. EC4486], gi\|16... gi\|189375037, gi... - gi\|189375037\|gb\|EDU93453.1\| lysyl-tRNA synthetase LysU [Escherichia coli O157:H7 str. EC869], gi\|168... gi\|189001831, gi... - gi\|189001831\|gb\|EDU70817.1\| lysyl-tRNA synthetase LysU [Escherichia coli O157:H7 str. EC4076], gi\|16... gi\|89110851, gi\|... - gi\|89110851\|ref\|AP_004631.1\| lysine tRNA synthetase, inducible [Escherichia coli str. K-12 substr. W... gi\|218363451, gi... - gi\|218556682\|ref\|YP_002389596.1\| lysyl-tRNA synthetase [Escherichia coli IAI1], gi\|218363451\|emb\|CAR... gi\|188488978, gi... - gi\|75514889\|ref\|ZP_00737118.1\| COG1190: Lysyl-tRNA synthetase (class II) [Escherichia coli 53638], g... gi\|217326188, gi... - gi\|217326188\|ref\|ZP_03442272.1\| lysyl-tRNA synthetase LysU [Escherichia coli O157:H7 str. TW14588], ... gi\|192931307, gi... - gi\|75259047\|ref\|ZP_00730415.1\| COG1190: Lysyl-tRNA synthetase (class II) [Escherichia coli E22], gi\|... gi\|75212057, gi\|... - gi\|75212057\|ref\|ZP_00712112.1\| COG1190: Lysyl-tRNA synthetase (class II) [Escherichia coli B171], gi... gi\|218697832, gi... - gi\|218697832\|ref\|YP_002405499.1\| lysyl-tRNA synthetase [Escherichia coli 55989], gi\|218354564\|emb\|CA... gi\|157069275, gi... - gi\|75197980\|ref\|ZP_00708050.1\| COG1190: Lysyl-tRNA synthetase (class II) [Escherichia coli HS], gi\|1...	496.0	[0..18]	[530..4]
SYK_IDILO - Lysine--tRNA ligase OS=Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR) GN=lysS PE=3 ... SYK_IDILO - Lysyl-tRNA synthetase OS=Idiomarina loihiensis GN=lysS PE=3 SV=1	496.0	[0..21]	[530..4]
gi\|74314615, gi\|... - gi\|74314615\|ref\|YP_313034.1\| lysyl-tRNA synthetase [Shigella sonnei Ss046], gi\|73858092\|gb\|AAZ90799....	496.0	[0..18]	[530..4]
gi\|190906366, gi... - gi\|75239099\|ref\|ZP_00723079.1\| COG1190: Lysyl-tRNA synthetase (class II) [Escherichia coli F11], gi\|... gi\|218692425, gi... - gi\|218692425\|ref\|YP_002400637.1\| lysyl-tRNA synthetase [Escherichia coli ED1a], gi\|218429989\|emb\|CAR... gi\|110644488, gi... - gi\|110644488\|ref\|YP_672218.1\| lysyl-tRNA synthetase [Escherichia coli 536], gi\|110346080\|gb\|ABG72317...	496.0	[0..18]	[530..4]
gi\|194423804, gi... - gi\|83587253\|ref\|ZP_00925882.1\| COG1190: Lysyl-tRNA synthetase (class II) [Escherichia coli 101-1], g... gi\|254290812, gi... - gi\|254290812\|ref\|YP_003056560.1\| lysine tRNA synthetase, inducible [Escherichia coli BL21(DE3)], gi\|... gi\|251787383, gi... - gi\|251787383\|ref\|YP_003001687.1\| hypothetical protein B21_03962 [Escherichia coli BL21], gi\|24237965... gi\|253975963, gi... - gi\|254164062\|ref\|YP_003047170.1\| lysine tRNA synthetase, inducible [Escherichia coli B str. REL606],...	496.0	[0..18]	[530..4]
gi\|193063477, gi... - gi\|75258488\|ref\|ZP_00729910.1\| COG1190: Lysyl-tRNA synthetase (class II) [Escherichia coli E22], gi\|...	496.0	[0..28]	[531..14]
SYK2_ECOL6 - Lysine--tRNA ligase, heat inducible OS=Escherichia coli O6 GN=lysU PE=3 SV=3 gi\|162138308 - gi\|162138308\|ref\|YP_543665.2\| lysyl-tRNA synthetase [Escherichia coli UTI89] gi\|117626414, gi... - gi\|117626414\|ref\|YP_859737.1\| lysyl-tRNA synthetase [Escherichia coli APEC O1], gi\|115515538\|gb\|ABJ0... SYK2_ECOL6 - Lysine--tRNA ligase, heat inducible OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) G... gi\|227886830, gi... - gi\|227886830\|ref\|ZP_04004635.1\| lysine--tRNA ligase [Escherichia coli 83972], gi\|227836172\|gb\|EEJ466... gi\|218434842, gi... - gi\|218707745\|ref\|YP_002415264.1\| lysyl-tRNA synthetase [Escherichia coli UMN026], gi\|218434842\|emb\|C... gi\|218367986, gi... - gi\|218561217\|ref\|YP_002394130.1\| lysyl-tRNA synthetase [Escherichia coli S88], gi\|218367986\|emb\|CAR0...	495.0	[0..18]	[530..4]

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Predicted Domain #1

Region A:
Residues: [1-531]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MISRGLLSKG ILSIIKRKNT GNLIPHVYYS EYHADIEERR KALGRLGISL YPSVTSDAST  60
   61 TTIPVIIEKW RNKITKSEIA MVRYTVCGRI SSIRYSGSKL AFFDVLYGNK KLQVVFNKKN 120
  121 IGTEEEMKGK FIPRLKALQK GDCIQCSGNV GRSGSGELSI YATELPKLLS PCLHPIPVKL 180
  181 TNYEKRFEKR FVDMMSNTKS LELLEKRYRI IESIRKFFSE RGFLEVETPI LSHHFGGATA 240
  241 RPFITSDIHK LPLTLRCAPE LWLKQLVIGG MNRVFELGKN FRNEGIDATH NPEFTSCEAY 300
  301 CAYLNLEGMK KLTEELIRFI CLTINGNLQI SGQTVDLEKG FEVIEFIPAL QKELNVELSP 360
  361 LDNSENCRKQ LISIFKRCEI MLPKTCTVAH LLDKLFDSLV LKYNTSSPKF VINHPEVMSP 420
  421 LAKSDIKLYG AVEQRISKRF ELYIGGYEIC NAYEEENDPV AQYHKFQAQK YDRLQLGDDE 480
  481 TPAPDSDFVH ALEYGLPPTA GWGMGVDRLV MLMTGQSKIS EILPFGSLRY V

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	141.0
Match:	1e1oA
Description:	Lysyl-tRNA synthetase (LysRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
lysine-tRNA ligase activity	5.79033103181143	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	3.53864660125764	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	3.53864660125764	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	3.52777284894652	bayes_pls_golite062009
phenylalanine-tRNA ligase activity	2.99105702052936	bayes_pls_golite062009
nucleic acid binding	2.69275272183315	bayes_pls_golite062009
ligase activity	2.56279938346489	bayes_pls_golite062009
serine-tRNA ligase activity	2.46505535069103	bayes_pls_golite062009
structural constituent of ribosome	2.43759174701552	bayes_pls_golite062009
glycine-tRNA ligase activity	2.29229136935761	bayes_pls_golite062009
binding	2.20683882867211	bayes_pls_golite062009
threonine-tRNA ligase activity	2.18642354927	bayes_pls_golite062009
structural molecule activity	2.08258913217268	bayes_pls_golite062009
DNA binding	1.97161900822354	bayes_pls_golite062009
alanine-tRNA ligase activity	1.82594054955281	bayes_pls_golite062009
histidine-tRNA ligase activity	1.72215103383322	bayes_pls_golite062009
translation regulator activity	1.46320772716954	bayes_pls_golite062009
translation factor activity, nucleic acid binding	1.40718318783582	bayes_pls_golite062009
translation initiation factor activity	0.96756670903925	bayes_pls_golite062009
aspartate-tRNA ligase activity	0.921774798819338	bayes_pls_golite062009
asparagine-tRNA ligase activity	0.921492123574877	bayes_pls_golite062009
structure-specific DNA binding	0.83085643154213	bayes_pls_golite062009
single-stranded DNA binding	0.56590887755068	bayes_pls_golite062009
transcription regulator activity	0.398606646713208	bayes_pls_golite062009
ribonuclease activity	0.305684604963838	bayes_pls_golite062009
protein binding	0.0528188351789111	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: