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View Structure Prediction Details

Protein: XNP-PB, XNP-PA
Organism: Drosophila melanogaster
Length: 1311 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for XNP-PB, XNP-PA.

Description E-value Query
Range
Subject
Range
gi|11870012 - gi|11870012|gb|AAG40586.1|AF217802_1 xnp/atr-x DNA helicase [Drosophila melanogaster]
637.0 [0..1] [1311..1]

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Predicted Domain #1
Region A:
Residues: [1-161]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKKNPNARH TDAATPLTTD DSNSSSVSRR ESATESKSAS ESESSPPRSN TKQSRTHKNV  60
   61 KASGKATVSS SSDSDQAVAN SSANDEEKEP VCKIRIVPLE KLLASPKTKE RPSRGSQQKN 120
  121 VTINDSSDEE PLKGSKLVLP ARKSRNKNAS IIELSDSEEV D

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [162-395]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEEESLLVAI PLPKEAQQTK PEKNSSKASK ESIEKRQKAQ KEATTSSARA IRSVNGTRRG  60
   61 SLSSERSSRA SSSRAESPPR PKRCVVRLKR VSLPKTKPAQ KPKKMSSDSE EAATTSKKSR 120
  121 QRRSKSESEA DSDYEAPAAE EEEEEERKSS GDEEEAANSS DSEVMPQRKR RRKKSESDKG 180
  181 SSDFEPEEKQ KKKGRKRIKK TSSGESDGDG DDDKQKNKRK HIRKIIKTKD LDLT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [396-939]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKEAAKEEDD RRKRIEDRQK LYNRIFVKSE SVEINELVLD FDEESKKALL QVDKGLLKKL  60
   61 KPHQVAGVKF MWDACFETLK ESQEKPGSGC ILAHCMGLGK TLQVVTLSHT LLVNTRRTGV 120
  121 DRVLIISPLS TVNNWAREFT SWMKFANRND IEVYDISRYK DKPTRIFKLN EWFNEGGVCI 180
  181 LGYDMYRILA NEKAKGLRKK QREQLMQALV DPGPDLVVCD EGHLLKNEKT SISKAVTRMR 240
  241 TKRRIVLTGT PLQNNLREYY CMIQFVKPNL LGTYKEYMNR FVNPITNGQY TDSTERDLRL 300
  301 MKHRSHILHK LLEGCIQRRD YSVLAPYLPP KHEYVVYTTL SELQQKLYGY YMTTHREQSG 360
  361 GDVVGKGARL FQDFQDLRRI WTHPMNLRVN SDNVIAKRLL SNDDSDMEGF ICDETDEDEA 420
  421 ASNSSDSCET FKSDASMSGL AASSGKVKKR KTRNGNAGGG DSDSDLEMLG GLGGGSSVQK 480
  481 DDPSEWWKPF VEERELNNVH HSPKLLILLR LLQQCEAIGD KLLVFSQSLQ SLDVIEHFLS 540
  541 LVDS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 88.0
Match: 1z3iX
Description: Structure of the SWI2/SNF2 chromatin remodeling domain of eukaryotic Rad54
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.16853848306485 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.36915495988847 bayes_pls_golite062009
pyrophosphatase activity 2.29436982996465 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.27303683020046 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.27190707957159 bayes_pls_golite062009
nucleic acid binding 2.09956015274464 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
DNA binding 1.87765278833074 bayes_pls_golite062009
ATPase activity 1.76238574289941 bayes_pls_golite062009
ATPase activity, coupled 1.57826779898847 bayes_pls_golite062009
DNA-dependent ATPase activity 1.23094623498843 bayes_pls_golite062009
motor activity 1.14667913749579 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
hydrolase activity 0.98565595572967 bayes_pls_golite062009
DNA helicase activity 0.75415390146713 bayes_pls_golite062009
purine nucleotide binding 0.725611289205392 bayes_pls_golite062009
nucleotide binding 0.717697610309727 bayes_pls_golite062009
purine ribonucleotide binding 0.713814218071151 bayes_pls_golite062009
ribonucleotide binding 0.713752628021599 bayes_pls_golite062009
transcription factor activity 0.682439846757997 bayes_pls_golite062009
microtubule motor activity 0.60036517876321 bayes_pls_golite062009
cytoskeletal protein binding 0.500462538667228 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.41398614759796 bayes_pls_golite062009
protein binding 0.193768631623192 bayes_pls_golite062009
ATP binding 0.19169045543599 bayes_pls_golite062009
adenyl ribonucleotide binding 0.165732470448462 bayes_pls_golite062009
adenyl nucleotide binding 0.162060759063149 bayes_pls_golite062009
substrate-specific transporter activity 0.144154288308693 bayes_pls_golite062009
centromeric DNA binding 0.120185906020979 bayes_pls_golite062009
active transmembrane transporter activity 0.114463153989353 bayes_pls_golite062009
structural constituent of ribosome 0.089234257580272 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009
actin binding 0.00482938540552702 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [940-1090]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTKNYEFEGD VGDFKGCWTS GKDYFRLDGS CSVEQREAMC KQFNNITNLR ARLFLISTRA  60
   61 GGLGINLVAA NRVVIFDVSW NPSHDTQSIF RVYRFGQIKP CYIYRLIAMG TMEQKVYERQ 120
  121 VAKQATAKRV IDEQQISRHY NQTDLMELYS Y

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.69897
Match: 1z5zA
Description: Sulfolobus solfataricus SWI2/SNF2 ATPase C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1091-1311]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELKPSTEREM PILPKDRLFA EILTEHEKLI FKYHEHDSLL EQEEHENLTE EERKSAWAEY  60
   61 EAEKTRTVQA SQYMSYDRNA FGNQVMGQFG NASGSVTSNK IFGFRSDILL QLLNMKISKD 120
  121 HQELNQNQVI QLVPTYLQQL YNEMNNGDPT MYKDLLNLHS NIVHPSGMYM NPLLYANQNP 180
  181 NAAGYNQGTG GVPPMAGGSV AHGPPAAPAP GFEPDKVYEI D

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle