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View Structure Prediction Details

Protein: DNApol-epsilon-PA
Organism: Drosophila melanogaster
Length: 2236 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DNApol-epsilon-PA.

Description E-value Query
Range
Subject
Range
gi|109497435, gi... - gi|62659079|ref|XP_222255.3| PREDICTED: similar to DNA polymerase epsilon, catalytic subunit A (DNA ...
2453.0 [0..1] [2234..1]

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Predicted Domain #1
Region A:
Residues: [1-819]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSSKGKVL QNTGKFVSEN RTEGDDFFNE AGYRQSREND KIDSKYGFDR VKDSQERTGY  60
   61 LINMHSNEVL DEDRRLIAAL DLFFIQMDGS RFKCTVAYQP YLLIRPEDNM HLEVARFLGR 120
  121 KYSGQISGLE HITKEDLDLP NHLSGLQQQY IKLSFLNQTA MTKVRRELMS AVKRNQERQK 180
  181 SNTYYMQMLA TSLAQSSAGS EDATLGKRQQ DYMDCIVDIR EHDVPYHVRV SIDLRIFCGQ 240
  241 WYNIRCRSGV ELPTITCRPD ILDRPEPVVL AFDIETTKLP LKFPDAQTDQ VMMISYMIDG 300
  301 QGYLITNREI ISSNVDDFEY TPKPEFEGNF IVFNEENEMQ LLQRFFDHIM EVRPHIIVTY 360
  361 NGDFFDWPFV ETRAAVYDLD MKQEIGFSKL RDGNYLSRPA IHMDCLCWVK RDSYLPVGSQ 420
  421 GLKAVAKAKL RYDPVELDPE DMCRMAVEQP QVLANYSVSD AVATYYLYMK YVHPFIFALN 480
  481 TIIPMEPDEI LRKGSGTLCE TLLMVEAYHA QIVYPNKHQS ELNKLSNEGH VLDSETYVGG 540
  541 HVEALESGVF RADIPCRFRL DPAMVKQLQE QVDAVLRHAI EVEEGIPLEK VLNLDEVRQE 600
  601 IVQGLQGLHD IPNRLEQPVI YHLDVGAMYP NIILTNRLQP SAMVSDLDCA ACDFNKPGVR 660
  661 CKRSMDWLWR GEMLPASRNE FQRIQQQLET EKFPPLFPGG PQRAFHELSK EDQAAYEKKR 720
  721 LTDYCRKAYK KTKLTKLETR TSTICQKENS FYVDTVRAFR DRRYEYKGLT KVAKASVNAA 780
  781 VASGDAAEIK AAKGREVLYD SLQLAHKCIL NSFYGYVMR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 98.69897
Match: 1tgoA
Description: Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA-directed DNA polymerase activity 11.2781960093187 bayes_pls_golite062009
DNA polymerase activity 11.2285838712952 bayes_pls_golite062009
nucleotidyltransferase activity 8.85826259809475 bayes_pls_golite062009
DNA primase activity 7.3506495327575 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.79232184185512 bayes_pls_golite062009
endonuclease activity 4.4589129578563 bayes_pls_golite062009
endodeoxyribonuclease activity 4.26114862034453 bayes_pls_golite062009
transferase activity 4.02382113115178 bayes_pls_golite062009
DNA binding 2.71295423886311 bayes_pls_golite062009
RNA polymerase activity 2.69726786045171 bayes_pls_golite062009
DNA-directed RNA polymerase activity 2.69726786045171 bayes_pls_golite062009
ribonuclease activity 2.66669472409706 bayes_pls_golite062009
nucleic acid binding 2.64264099197997 bayes_pls_golite062009
deoxyribonuclease activity 2.58611070700103 bayes_pls_golite062009
transcription regulator activity 2.20855917457806 bayes_pls_golite062009
binding 1.83109253387887 bayes_pls_golite062009
exonuclease activity 1.68989335095363 bayes_pls_golite062009
exoribonuclease activity 1.41353777396851 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 1.33509846387956 bayes_pls_golite062009
transcription factor activity 1.17659544650821 bayes_pls_golite062009
chromatin binding 1.11900638060439 bayes_pls_golite062009
mismatch repair complex binding 1.10201551909695 bayes_pls_golite062009
damaged DNA binding 1.08077297289305 bayes_pls_golite062009
catalytic activity 1.04899053677564 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.98331180621651 bayes_pls_golite062009
3'-5' exonuclease activity 0.78558451404229 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 0.708753843279937 bayes_pls_golite062009
MutLalpha complex binding 0.672116175206859 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.598360955770972 bayes_pls_golite062009
0.49473250705373 bayes_pls_golite062009
structure-specific DNA binding 0.433956339585542 bayes_pls_golite062009
protein binding 0.354190470641287 bayes_pls_golite062009
nuclease activity 0.332024848299731 bayes_pls_golite062009
DNA helicase activity 0.283883977748512 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.228341362435973 bayes_pls_golite062009
single-stranded DNA binding 0.206750180223289 bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity 0.19596408995795 bayes_pls_golite062009
5'-3' exonuclease activity 0.154583332107704 bayes_pls_golite062009
transcription activator activity 0.104967281174106 bayes_pls_golite062009
endoribonuclease activity 0.016619833072142 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [820-1139]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGARWHSMPM AGIVCLTGSN IITKAREIIE RVGRPLELDT DGIWCILPGS FPQEFTIHTS  60
   61 HEKKKKINIS YPNAVLNTMV KDHFTNDQYH ELRKDKENNL PKYDIRDENS IFFEVDGPYL 120
  121 AMVLPAAKEE GKKLKKRYAV FNFDGTLAEL KGFEVKRRGE LQLIKNFQSS VFEAFLAGST 180
  181 LEECYASVAK VADYWLDVLY SRGSNLPDSE LFELISENKS MSKKLEEYGA QKSTSISTAK 240
  241 RLAEFLGEQM VKDAGLACKY IISKKPEGAP VTERAIPLAI FQSEPSVRRH HLRRWLKDNT 300
  301 MGDADIRDVL DWNYYIERLG 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.18
Match: 1q8iA
Description: Crystal structure of ESCHERICHIA coli DNA Polymerase II
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA-directed DNA polymerase activity 10.6911520838834 bayes_pls_golite062009
DNA polymerase activity 10.645713605123 bayes_pls_golite062009
nucleotidyltransferase activity 8.39147983801981 bayes_pls_golite062009
DNA primase activity 6.94341770434315 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.49699229430126 bayes_pls_golite062009
transferase activity 3.80228208941612 bayes_pls_golite062009
DNA binding 2.64619844447089 bayes_pls_golite062009
nucleic acid binding 2.6018293992859 bayes_pls_golite062009
deoxyribonuclease activity 2.53877834217178 bayes_pls_golite062009
DNA-directed RNA polymerase activity 2.39159655026329 bayes_pls_golite062009
RNA polymerase activity 2.39159655026329 bayes_pls_golite062009
binding 1.84871443682239 bayes_pls_golite062009
exonuclease activity 1.38951646742998 bayes_pls_golite062009
catalytic activity 0.985794797454925 bayes_pls_golite062009
damaged DNA binding 0.903519456111979 bayes_pls_golite062009
chromatin binding 0.891218870764102 bayes_pls_golite062009
structure-specific DNA binding 0.431057665208185 bayes_pls_golite062009
3'-5' exonuclease activity 0.427833022898625 bayes_pls_golite062009
protein binding 0.366887851366715 bayes_pls_golite062009
nuclease activity 0.126991239633667 bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity 0.024241485627603 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [1140-1240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTIQKIITIP AALQGLANPV PRVQHPDWLH KKMLEKNDVL KQRRINEMFT SRPKPKPLAT  60
   61 EEDKLADMED LAGKDGGEGA AGCPIVTKRK RIQLEEHDDE E

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [1241-1417]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQPQATTWRQ ALGAPPPIGE TRKTIVEWVR FQKKKWKWQQ DQRQRNRQAS KRTRGEDPPV  60
   61 VRATGSTATL GGFLRRAQRT LLDQPWQIVQ LVPVDDLGHF TVWALIGEEL HKIKLTVPRI 120
  121 FYVNQRSAAP PEEGQLWRKV NRVLPRSRPV FNLYRYSVPE QLFRDNSLGM LADLATP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1418-1495]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DIEGIYETQM TLEFRALMDM GCICGVQREE ARRLAQLATK DLETFSIEQL EQRPQTQVKY  60
   61 LASANNRLRK IYLYQHNT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1496-1596]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTAKKEIWSL ILMPSKKAFV FALDTVRANQ MPNMRQLYTA ERLALLKNLT AEEQDKIPVE  60
   61 DYTFEVLIEV DVKQIYRHIQ RALTTYKQEH QGPTILCLQT A

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1597-1754]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSARKLSLAM PILLEFPQAE IHISDDASLL SGLDWQRQGS RAVIRHFLNL NNVLDLMLDQ  60
   61 CRYFHVPIGN MPPDTVLFGA DLFFARLLQR HNFVLWWSAS TRPDLGGREA DDSRLLAEFE 120
  121 ESISVVQNKA GFYPDVCVEL ALDSLAVSAL LQSTRIQE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1755-1924]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGASSAITF DVMPQVSLEE MIGTVPAATL PSYDETALCS AAFRVMRSMV NGWLREVSIN  60
   61 RNIFSDFQIV HFYRWVRSSN ALLYDPALRR SLNNLMRKMF LRIIAEFKRL GATIIYADFN 120
  121 RIILSSGKKT VSDALGYVDY IVQSLRNKEM FHSIQLSFEQ CWNFMLWMDQ 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1925-2136]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANFSGIRGKL PKGIDETVSS IVSTTMIRDS ERNQDDDEDE EEDSENRDPV ESNEAEQDQE  60
   61 DELSLELNWT IGEHLPDENE CREKFESLLT LFMQSLAEKK TTEQAIKDIS HCAFDFILKL 120
  121 HKNYGKGKPS PGLELIRTLI KALSVDKTLA EQINELRRNM LRLVGIGEFS DLAEWEDPCD 180
  181 SHIINEVICK ACNHCRDLDL CKDKHRAMKD GV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [2137-2236]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVWLCAQCYV AYDNEEIEMR MLDALQRKMM SYVLQDLRCS RCSEIKRENL AEFCTCAGNF  60
   61 VPLISGKDIQ TLLGTFNKVA ANHKMQLLQQ TVHQALTTPR 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle