| Protein: | Dad-PC, Dad-PB, ... |
| Organism: | Drosophila melanogaster |
| Length: | 568 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dad-PC, Dad-PB, ....
| Description | E-value | Query Range |
Subject Range |
|
|
655.0 | [0..1] | [568..1] |
|
Region A: Residues: [1-125] |
1 11 21 31 41 51
| | | | | |
1 MIFPREKKVL WRYASSNNPS NGVSAAPPAQ PPRPPPPPHR PRPHQCTPSF GYSCNEEDSL 60
61 AMRQTPLPPY SSIACGMDCS SSNSSSCGQS LSLSQGQGHN NNNSHPYRRL PNHMDVLPPP 120
121 PSACD
|
| Detection Method: |  |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [126-339] |
1 11 21 31 41 51
| | | | | |
1 RCCTAPGYSC ASSCDDMLID GSDLDQDRSP DQGQVQPVDR RMISATTFTT MFRKCCGGAT 60
61 ESTSGSTLTI PVSTSRATAH PPQTQAQNGK RFREDFEALM KQLKRKQRNE LLLAVKSRLD 120
121 PPTKTQRDVV EPTTTTAPTY LQCILIPCKT QTVWEPHVTA SRLFFWRELW NAKELKRLPT 180
181 CPAARDCIYM CCNPLHWFRI LHQPETESPT PPYQ
|
| Detection Method: | |
| Confidence: | 43.0 |
| Match: | 1ozjA |
| Description: | Crystal structure of Smad3-MH1 bound to DNA at 2.4 A resolution |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [340-568] |
1 11 21 31 41 51
| | | | | |
1 RSKMLRLKDA DFEEDSQNDA KSAALSTWSA ESTSISNIYK PALYESVTTD GKDHNINSQV 60
61 WCQIAYWEMA HRVGEFFHAK TNAVNIYTDG IVASEVDSMC LRDLTPAGNQ IHSVVPKARH 120
121 TVGLGVTLSL ENGDVWIYNR GNTTIFVDSP TLSENLDRVC KVMPGYCLKA FETNRAELLS 180
181 MRDHGHHPMG PVDYFSIKIS FGKGWGRDYK RQDIMGCPCW LEVHFSHLR
|
| Detection Method: | |
| Confidence: | 80.221849 |
| Match: | 1devA |
| Description: | Smad2 MH2 domain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| R-SMAD binding | 5.38307893104629 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, cytoplasmic mediator activity | 5.17758651944685 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase signaling protein activity | 4.95270065635384 | bayes_pls_golite062009 |
| co-SMAD binding | 4.57538059815089 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity | 4.49077041445033 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 4.40792626415753 | bayes_pls_golite062009 |
| SMAD binding | 4.23556933524744 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 4.11302084276027 | bayes_pls_golite062009 |
| binding | 3.6561903894619 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity | 3.61855740138956 | bayes_pls_golite062009 |
| transcription regulator activity | 3.49687772656017 | bayes_pls_golite062009 |
| protein binding | 3.44553762357492 | bayes_pls_golite062009 |
| DNA binding | 3.30334070294767 | bayes_pls_golite062009 |
| type I transforming growth factor beta receptor binding | 3.25693690222359 | bayes_pls_golite062009 |
| nucleic acid binding | 3.21526555447097 | bayes_pls_golite062009 |
| acid-amino acid ligase activity | 3.11943104361829 | bayes_pls_golite062009 |
| receptor signaling protein activity | 3.08220855629618 | bayes_pls_golite062009 |
| transcription activator activity | 2.94935902482394 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 2.94401714632865 | bayes_pls_golite062009 |
| signal transducer activity | 2.90288654612667 | bayes_pls_golite062009 |
| molecular transducer activity | 2.90288654612667 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 2.88406197124131 | bayes_pls_golite062009 |
| activin binding | 2.85561990563659 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 2.61166537801555 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase binding | 2.57320437127906 | bayes_pls_golite062009 |
| transforming growth factor beta receptor binding | 2.57320437127906 | bayes_pls_golite062009 |
| phosphatase activity | 2.46582579847871 | bayes_pls_golite062009 |
| phosphoric ester hydrolase activity | 2.41505949322677 | bayes_pls_golite062009 |
| promoter binding | 2.30493918456602 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 2.1294440466744 | bayes_pls_golite062009 |
| transcription factor activity | 2.08449567315174 | bayes_pls_golite062009 |
| collagen binding | 1.9825610927799 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.88096476099716 | bayes_pls_golite062009 |
| kinase activity | 1.82476774968305 | bayes_pls_golite062009 |
| transcription repressor activity | 1.74929788315626 | bayes_pls_golite062009 |
| protein kinase activity | 1.73373132141588 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.66058356077795 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, common-partner cytoplasmic mediator activity | 1.61493700485683 | bayes_pls_golite062009 |
| I-SMAD binding | 1.6033600450778 | bayes_pls_golite062009 |
| chromatin binding | 1.44267609273288 | bayes_pls_golite062009 |
| small conjugating protein binding | 1.3559369584113 | bayes_pls_golite062009 |
| structure-specific DNA binding | 1.32552524966562 | bayes_pls_golite062009 |
| transferase activity | 1.29860325699399 | bayes_pls_golite062009 |
| ubiquitin binding | 1.28191134965346 | bayes_pls_golite062009 |
| double-stranded DNA binding | 1.21988722144674 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 1.1868962075754 | bayes_pls_golite062009 |
| receptor binding | 1.1261895404991 | bayes_pls_golite062009 |
| cell adhesion molecule binding | 1.10293974101617 | bayes_pls_golite062009 |
| ligase activity, forming carbon-nitrogen bonds | 1.02636679142543 | bayes_pls_golite062009 |
| histone binding | 1.01074250987871 | bayes_pls_golite062009 |
| transcription factor binding | 0.95553719139833 | bayes_pls_golite062009 |
| ubiquitin protein ligase binding | 0.85140744915405 | bayes_pls_golite062009 |
| hydrolase activity | 0.711787881321496 | bayes_pls_golite062009 |
| RNA binding | 0.403713641965787 | bayes_pls_golite062009 |
| enzyme binding | 0.34998623523914 | bayes_pls_golite062009 |
| protein dimerization activity | 0.33340925100096 | bayes_pls_golite062009 |
| specific transcriptional repressor activity | 0.15013949452504 | bayes_pls_golite062009 |
| identical protein binding | 0.0513801649373811 | bayes_pls_golite062009 |
| protein homodimerization activity | 0.0339057097360133 | bayes_pls_golite062009 |
