| Protein: | Iap2-PA, Iap2-PB |
| Organism: | Drosophila melanogaster |
| Length: | 498 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Iap2-PA, Iap2-PB.
| Description | E-value | Query Range |
Subject Range |
|
|
407.0 | [0..5] | [498..25] |
|
Region A: Residues: [1-93] |
1 11 21 31 41 51
| | | | | |
1 MTELGMELES VRLATFGEWP LNAPVSAEDL VANGFFATGN WLEAECHFCH VRIDRWEYGD 60
61 QVAERHRRSS PICSMVLAPN HCGNVPRSQE SDN
|
| Detection Method: |  |
| Confidence: | 27.522879 |
| Match: | 1tw6A |
| Description: | Structure of an ML-IAP/XIAP chimera bound to a 9mer peptide derived from Smac |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| caspase inhibitor activity | 3.37793799691411 | bayes_pls_golite062009 |
| protein binding | 2.82801305666365 | bayes_pls_golite062009 |
| binding | 2.82472291325192 | bayes_pls_golite062009 |
| caspase regulator activity | 2.78624473612776 | bayes_pls_golite062009 |
| cysteine-type endopeptidase inhibitor activity | 2.43952820346737 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 1.24291003560785 | bayes_pls_golite062009 |
| enzyme inhibitor activity | 1.18464294370673 | bayes_pls_golite062009 |
| microtubule binding | 1.03349057074077 | bayes_pls_golite062009 |
| tubulin binding | 1.0137804715367 | bayes_pls_golite062009 |
| enzyme regulator activity | 0.515008648709161 | bayes_pls_golite062009 |
| protein dimerization activity | 0.204341973906209 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 0.0431703651486497 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 0.0242766345667098 | bayes_pls_golite062009 |
| cofactor binding | 0.0023150693787124 | bayes_pls_golite062009 |
|
Region A: Residues: [94-193] |
1 11 21 31 41 51
| | | | | |
1 EGNSVVDSPE SCSCPDLLLE ANRLVTFKDW PNPNITPQAL AKAGFYYLNR LDHVKCVWCN 60
61 GVIAKWEKND NAFEEHKRFF PQCPRVQMGP LIEFATGKNL
|
| Detection Method: | |
| Confidence: | 24.0 |
| Match: | 1jd4A |
| Description: | BIR2 domain of DIAP1 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| caspase inhibitor activity | 3.37793799691411 | bayes_pls_golite062009 |
| protein binding | 2.82801305666365 | bayes_pls_golite062009 |
| binding | 2.82472291325192 | bayes_pls_golite062009 |
| caspase regulator activity | 2.78624473612776 | bayes_pls_golite062009 |
| cysteine-type endopeptidase inhibitor activity | 2.43952820346737 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 1.24291003560785 | bayes_pls_golite062009 |
| enzyme inhibitor activity | 1.18464294370673 | bayes_pls_golite062009 |
| microtubule binding | 1.03349057074077 | bayes_pls_golite062009 |
| tubulin binding | 1.0137804715367 | bayes_pls_golite062009 |
| enzyme regulator activity | 0.515008648709161 | bayes_pls_golite062009 |
| protein dimerization activity | 0.204341973906209 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 0.0431703651486497 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 0.0242766345667098 | bayes_pls_golite062009 |
| cofactor binding | 0.0023150693787124 | bayes_pls_golite062009 |
|
Region A: Residues: [194-305] |
1 11 21 31 41 51
| | | | | |
1 DELGIQPTTL PLRPKYACVD ARLRTFTDWP ISNIQPASAL AQAGLYYQKI GDQVRCFHCN 60
61 IGLRSWQKED EPWFEHAKWS PKCQFVLLAK GPAYVSEVLA TTAANASSQP AT
|
| Detection Method: | |
| Confidence: | 23.39794 |
| Match: | 1qbhA |
| Description: | 2MIHB/C-IAP-1 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| caspase inhibitor activity | 3.37793799691411 | bayes_pls_golite062009 |
| protein binding | 2.82801305666365 | bayes_pls_golite062009 |
| binding | 2.82472291325192 | bayes_pls_golite062009 |
| caspase regulator activity | 2.78624473612776 | bayes_pls_golite062009 |
| cysteine-type endopeptidase inhibitor activity | 2.43952820346737 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 1.24291003560785 | bayes_pls_golite062009 |
| enzyme inhibitor activity | 1.18464294370673 | bayes_pls_golite062009 |
| microtubule binding | 1.03349057074077 | bayes_pls_golite062009 |
| tubulin binding | 1.0137804715367 | bayes_pls_golite062009 |
| enzyme regulator activity | 0.515008648709161 | bayes_pls_golite062009 |
| protein dimerization activity | 0.204341973906209 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 0.0431703651486497 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 0.0242766345667098 | bayes_pls_golite062009 |
| cofactor binding | 0.0023150693787124 | bayes_pls_golite062009 |
|
Region A: Residues: [306-498] |
1 11 21 31 41 51
| | | | | |
1 APAPTLQADV LMDEAPAKEA LALGIDGGVV RNAIQRKLLS SGCAFSTLDE LLHDIFDDAG 60
61 AGAALEVREP PEPSAPFIEP CQATTSKAAS VPIPVADSIP AKPQAAEAVA NISKITDEIQ 120
121 KMSVATPNGN LSLEEENRQL KDARLCKVCL DEEVGVVFLP CGHLATCNQC APSVANCPMC 180
181 RADIKGFVRT FLS
|
| Detection Method: | |
| Confidence: | 8.39794 |
| Match: | 1fbvA |
| Description: | Cbl; N-terminal domain of cbl (N-cbl); CBL |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| protein binding | 3.19631993182765 | bayes_pls_golite062009 |
| binding | 3.12724619324809 | bayes_pls_golite062009 |
| molecular transducer activity | 2.92323609459085 | bayes_pls_golite062009 |
| signal transducer activity | 2.92323609459085 | bayes_pls_golite062009 |
| molecular adaptor activity | 1.81145713371725 | bayes_pls_golite062009 |
| SH3/SH2 adaptor activity | 1.59474164216385 | bayes_pls_golite062009 |
| insulin receptor binding | 1.18707666182719 | bayes_pls_golite062009 |
| receptor binding | 1.09099343809921 | bayes_pls_golite062009 |
| protein binding, bridging | 0.83823250804321 | bayes_pls_golite062009 |
| protein phosphorylated amino acid binding | 0.649814096718101 | bayes_pls_golite062009 |
| transcription regulator activity | 0.540818657754841 | bayes_pls_golite062009 |
| SH2 domain binding | 0.353553274217716 | bayes_pls_golite062009 |
| nucleic acid binding | 0.352421112301971 | bayes_pls_golite062009 |
| protein complex binding | 0.32615263839176 | bayes_pls_golite062009 |
| phosphotyrosine binding | 0.311079584914389 | bayes_pls_golite062009 |
| DNA binding | 0.281643350069021 | bayes_pls_golite062009 |
| phosphoprotein binding | 0.16798254471727 | bayes_pls_golite062009 |
