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View Structure Prediction Details

Protein: FBpp0311783, dpa-PA
Organism: Drosophila melanogaster
Length: 866 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0311783, dpa-PA.

Description E-value Query
Range
Subject
Range
gi|1245870 - gi|1245870|gb|AAB35644.1| replication factors MCM [Drosophila sp.]
gi|2133664 - pir||S59872 replication licensing factor MCM4 - fruit fly (Drosophila melanogaster)
700.0 [0..1] [866..1]

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Predicted Domain #1
Region A:
Residues: [1-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSPARSPSV GGATPKQGAR TPTRGIASQD VETPMRMGPG RAVRPSDNIS LPPTSPGNIS  60
   61 LPATSPARGL GANMSEIDLS SPLNYGTPSS MGSIRTPRSG IRGTPLRARP DIRTDKRIRQ 120
  121 VAIGGGSGLE PIPEKGSETT DPVSESSQAP QLVVWGTNVV VS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.48
Match: 2j63A
Description: No description for 2j63A was found.

Predicted Domain #2
Region A:
Residues: [163-276]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QCKSKFKSFI MRFIDPSAEQ DEISENIDVN QPLYLQKLEE IHTLEEPYLN LNCAHLKTFD  60
   61 QDLYRQLICY PQEVIPGFDM AINEMFFERY PAALLEHQIQ VRPFNADKTR NMRS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.09691
Match: 1ltlA
Description: DNA replication initiator (cdc21/cdc54) N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [277-382]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNPEDMDQLI SISGMVIRSS NVIPEMREAF FSCNICSFST TVEVDRGRIN QPTLCTNCNT  60
   61 NHCFRLIHNR SEFTDKQLVK LQESPDDMAA GQTPHNVLLY AHNDLV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.05
Match: 1ltlA
Description: DNA replication initiator (cdc21/cdc54) N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [383-468]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKVQPGDRVT VTGIYRATPL KTGGLSSSVK SVYKTHVDVV HFRKVDNKRL YEDEEGKDHI  60
   61 FPPERVELLQ LLAKKPDIYD RLARAI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.69897
Match: 1ny5A
Description: Crystal structure of sigm54 activator (AAA+ ATPase) in the inactive state
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [469-725]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APSIYENDDI KKGILLQLFG GTKKKHATLG RQNFRSEIHL LLCGDPGTSK SQMLQYVFNL  60
   61 VPRSQYTSGR GSSAVGLTAY VTKDPETRQL VLQTGALVLA DNGVCCIDEF DKMNDSTRSV 120
  121 LHEVMEQQTL SIAKAGIICQ LNARTSILAA ANPAESQWNK RKNIIDNVQL PHTLLSRFDL 180
  181 IFLVLDPQDE IFDKRLASHL VSLYYVTRHE EEDTMFDMSV LRDYIAYARE HLSPTLSDEA 240
  241 QQRLIQAYVD MRKVGAG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.69897
Match: 1ofhA
Description: HslU
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA clamp loader activity 4.91429252297969 bayes_pls_golite062009
protein-DNA loading ATPase activity 4.80695929076807 bayes_pls_golite062009
motor activity 2.79327761685782 bayes_pls_golite062009
microtubule motor activity 2.74365461017633 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.66107861968804 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
telomeric DNA binding 2.0142766759353 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
DNA replication origin binding 1.62491387774159 bayes_pls_golite062009
ribonucleotide binding 1.53142082854758 bayes_pls_golite062009
purine nucleotide binding 1.52938239070386 bayes_pls_golite062009
purine ribonucleotide binding 1.52887308780164 bayes_pls_golite062009
nucleotide binding 1.52746968836881 bayes_pls_golite062009
structural constituent of ribosome 1.47858140861683 bayes_pls_golite062009
cytoskeletal protein binding 1.40488517180956 bayes_pls_golite062009
ATP binding 1.23942044024113 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
adenyl ribonucleotide binding 1.21044170258803 bayes_pls_golite062009
structure-specific DNA binding 1.20315703345493 bayes_pls_golite062009
adenyl nucleotide binding 1.19481945569892 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
kinase activity 1.11120928120082 bayes_pls_golite062009
histone acetyltransferase activity 1.05990253628867 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.05990253628867 bayes_pls_golite062009
double-stranded DNA binding 1.05408274676326 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
tubulin binding 0.979946830272106 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.908046791062776 bayes_pls_golite062009
microtubule binding 0.907162506177187 bayes_pls_golite062009
transcription activator activity 0.889929694023098 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
actin binding 0.883285269827407 bayes_pls_golite062009
structural molecule activity 0.86514677273731 bayes_pls_golite062009
transcription repressor activity 0.862685397469217 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 0.8469248456592 bayes_pls_golite062009
single-stranded telomeric DNA binding 0.700780808446722 bayes_pls_golite062009
sequence-specific DNA binding 0.543891899378373 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.421921195209539 bayes_pls_golite062009
single-stranded DNA binding 0.406600732518248 bayes_pls_golite062009
protein kinase activity 0.351308564667977 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
four-way junction helicase activity 0.26252931460003 bayes_pls_golite062009
exodeoxyribonuclease V activity 0.185603938981231 bayes_pls_golite062009
RNA helicase activity 0.18426050934025 bayes_pls_golite062009
transferase activity 0.175269600441384 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.156278588350022 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
RNA-dependent ATPase activity 0.14606996093053 bayes_pls_golite062009
mismatched DNA binding 0.13366911641814 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.13050483816765 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
3'-5' DNA helicase activity 0.0769112340058804 bayes_pls_golite062009
microfilament motor activity 0.0313060889304495 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.0223627159838333 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [726-866]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGQISAYPRQ LESLIRLSEA HAKVRLSNQV ELLDVEEAWR LHREALKQSA TDPLSGKIDV  60
   61 GILTTGLSTA ARKKRADLVA AIKENLKKKG KVLTVPYQKL FSDIKEGSQI MITREQFEDA 120
  121 LKEVQDEGAI VVMGKNTIRI C

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.522879
Match: 2r44A
Description: No description for 2r44A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle