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View Structure Prediction Details

Protein: gi|123997931, gi...
Organism: synthetic construct
Length: 525 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|123997931, gi....

Description E-value Query
Range
Subject
Range
gi|114581226 - gi|114581226|ref|XP_515834.2| PREDICTED: signal transducing adaptor molecule 2 isoform 3 [Pan troglo...
0.0 [1..525] [1..525]
gi|21265031 - gi|21265031|ref|NP_005834.3| signal transducing adaptor molecule 2 [Homo sapiens]
0.0 [1..525] [1..525]
gi|86438218, gi|... - gi|86438218|gb|AAI12605.1| Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 [Bos ta...
1.0E-95 [1..513] [1..512]
STAM2_MOUSE - Signal transducing adapter molecule 2 OS=Mus musculus GN=Stam2 PE=1 SV=1
2.0E-94 [1..525] [1..523]
STAM2_RAT - Signal transducing adapter molecule 2 OS=Rattus norvegicus GN=Stam2 PE=2 SV=1
6.0E-94 [1..525] [1..523]
gi|73984397 - gi|73984397|ref|XP_533357.2| PREDICTED: similar to Signal transducing adapter molecule 2 (STAM-2) [C...
3.0E-92 [14..525] [148..659]
STAM2_CHICK - Signal transducing adapter molecule 2 OS=Gallus gallus GN=STAM2 PE=1 SV=1
2.0E-78 [1..439] [1..437]

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Predicted Domain #1
Region A:
Residues: [1-75]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLFTANPFE QDVEKATNEY NTTEDWSLIM DICDKVGSTP NGAKDCLKAI MKRVNHKVPH  60
   61 VALQALTLLG ACVAN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.69897
Match: 1x5bA
Description: The solution structure of the VHS domain of human Signal transducing adaptor molecule 2
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [76-161]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CGKIFHLEVC SRDFATEVRA VIKNKAHPKV CEKLKSLMVE WSEEFQKDPQ FSLISATIKS  60
   61 MKEEGITFPP AGSQTVSAAA KNGTSS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.67
Match: 1x5bA
Description: The solution structure of the VHS domain of human Signal transducing adaptor molecule 2
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [162-262]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKNKEDEDIA KAIELSLQEQ KQQHTETKSL YPSSEIQLNN KVARKVRALY DFEAVEDNEL  60
   61 TFKHGEIIIV LDDSDANWWK GENHRGIGLF PSNFVTTNLN I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.09691
Match: 1x2qA
Description: Solution structure of the SH3 domain of the Signal transducing adaptor molecule 2
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [263-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETEAAAVDKL NVIDDDVEEI KKSEPEPVYI DEDKMDRALQ VLQSIDPTDS KPDSQDLLDL  60
   61 EDICQQMGPM IDEKLEEIDR KHSELSELNV KVLEALELYN KLVNEAPV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.522879
Match: 1bljA
Description: NMR ENSEMBLE OF BLK SH2 DOMAIN, 20 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.12724619324809 bayes_pls_golite062009
protein binding 2.14586566310919 bayes_pls_golite062009
molecular adaptor activity 1.33740973673697 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.2323381312171 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.02097165614658 bayes_pls_golite062009
signal transducer activity 0.999269271132931 bayes_pls_golite062009
molecular transducer activity 0.999269271132931 bayes_pls_golite062009
small conjugating protein ligase activity 0.938262449967509 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
transcription regulator activity 0.540818657754841 bayes_pls_golite062009
hydrolase activity 0.539213162060111 bayes_pls_golite062009
nucleic acid binding 0.476094076158571 bayes_pls_golite062009
DNA binding 0.281643350069021 bayes_pls_golite062009
phosphoprotein binding 0.16798254471727 bayes_pls_golite062009
acid-amino acid ligase activity 0.125965304296204 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [371-465]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSVYSKLHPP AHYPPASSGV PMQTYPVQSH GGNYMGQSIH QVTVAQSYSL GPDQIGPLRS  60
   61 LPPNVNSSVT AQPAQTSYLS TGQDTVSNPT YMNQN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.06
Match: 1pk8A
Description: Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [466-525]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNLQSATGTT AYTQQMGMSV DMSSYQNTTS NLPQLAGFPV TVPAHPVAQQ HTNYHQQPLL  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle