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View Structure Prediction Details

Protein: ANAPC5
Organism: Homo sapiens
Length: 755 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ANAPC5.

Description E-value Query
Range
Subject
Range
gi|109495904 - gi|109495904|ref|XP_213783.3| PREDICTED: similar to Anaphase-promoting complex subunit 5 (APC5) (Cyc...
0.0 [1..755] [56..807]
gi|6180013 - gi|6180013|gb|AAF05753.1|AF191339_1 anaphase-promoting complex subunit 5 [Homo sapiens]
0.0 [1..755] [1..755]
gi|114647436 - gi|114647436|ref|XP_001166115.1| PREDICTED: anaphase-promoting complex subunit 5 isoform 11 [Pan tro...
0.0 [1..755] [1..795]
gi|57105586 - gi|57105586|ref|XP_534668.1| PREDICTED: similar to anaphase-promoting complex subunit 5 isoform 1 [C...
0.0 [1..755] [1..755]

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Predicted Domain #1
Region A:
Residues: [1-189]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASVHESLYF NPMMTNGVVH ANVFGIKDWV TPYKIAVLVL LNEMSRTGEG AVSLMERRRL  60
   61 NQLLLPLLQG PDITLSKLYK LIEESCPQLA NSVQIRIKLM AEGELKDMEQ FFDDLSDSFS 120
  121 GTEPEVHKTS VVGLFLRHMI LAYSKLSFSQ VFKLYTALQQ YFQNGEKKTV EDADMELTSR 180
  181 DEGERKMEK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [190-314]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EELDVSVREE EVSCSGPLSQ KQAEFFLSQQ ASLLKNDETK ALTPASLQKE LNNLLKFNPD  60
   61 FAEAHYLSYL NNLRVQDVFS STHSLLHYFD RLILTGAESK SNGEEGYGRS LRYAALNLAA 120
  121 LHCRF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.861 a.7.6 Ribosomal protein S20

Predicted Domain #3
Region A:
Residues: [315-755]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GHYQQAELAL QEAIRIAQES NDHVCLQHCL SWLYVLGQKR SDSYVLLEHS VKKAVHFGLP  60
   61 YLASLGIQSL VQQRAFAGKT ANKLMDALKD SDLLHWKHSL SELIDISIAQ KTAIWRLYGR 120
  121 STMALQQAQM LLSMNSLEAV NAGVQQNNTE SFAVALCHLA ELHAEQGCFA AASEVLKHLK 180
  181 ERFPPNSQHA QLWMLCDQKI QFDRAMNDGK YHLADSLVTG ITALNSIEGV YRKAVVLQAQ 240
  241 NQMSEAHKLL QKLLVHCQKL KNTEMVISVL LSVAELYWRS SSPTIALPML LQALALSKEY 300
  301 RLQYLASETV LNLAFAQLIL GIPEQALSLL HMAIEPILAD GAILDKGRAM FLVAKCQVAS 360
  361 AASYDQPKKA EALEAAIENL NEAKNYFAKV DCKERIRDVV YFQARLYHTL GKTQERNRCA 420
  421 MLFRQLHQEL PSHGVPLINH L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.30103
Match: 1w3bA
Description: The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 4.81092926633672 bayes_pls_golite062009
small conjugating protein ligase activity 4.73323750175899 bayes_pls_golite062009
acid-amino acid ligase activity 4.038463864925 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 3.25461549315207 bayes_pls_golite062009
binding 2.52126334054344 bayes_pls_golite062009
ligase activity 1.72049482453565 bayes_pls_golite062009
protein binding 1.52807685989528 bayes_pls_golite062009
hydrolase activity 0.619711232527193 bayes_pls_golite062009
enzyme binding 0.44905827271946 bayes_pls_golite062009
nucleic acid binding 0.41706917101675 bayes_pls_golite062009
transcription regulator activity 0.322371143360832 bayes_pls_golite062009
DNA binding 0.17736976899009 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle