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View Structure Prediction Details

Protein: SGT1
Organism: Saccharomyces cerevisiae
Length: 395 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SGT1.

Description E-value Query
Range
Subject
Range
SGT1_YEAST - Protein SGT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SGT1 PE=1 SV=1
SGT1 - Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex a...
7.0E-84 [1..395] [1..395]
gi|17017306 - gi|17017306|gb|AAL33610.1|AF439974_1 SGT1 [Hordeum vulgare]
2.0E-78 [4..395] [6..371]
gi|6581058 - gi|6581058|gb|AAF18438.1|AF192467_1 Sgt1 [Oryza sativa]
2.0E-75 [4..395] [6..365]
gi|12841721 - gi|12841721|dbj|BAB25326.1| unnamed protein product [Mus musculus]
6.0E-72 [61..395] [30..336]
gi|6468695 - gi|6468695|emb|CAB61630.1| putative protein phosphatase [Rubus idaeus]
1.0E-71 [42..395] [6..325]
SGT1A_ARATH - Protein SGT1 homolog A OS=Arabidopsis thaliana GN=SGT1A PE=1 SV=1
2.0E-70 [4..395] [2..348]
gi|123994865, gi... - gi|60655001|gb|AAX32064.1| suppressor of G2 allele of SKP1 [synthetic construct], gi|60654999|gb|AAX...
gi|114649870 - gi|114649870|ref|XP_509801.2| PREDICTED: similar to suppressor of G2 allele of skp1 homolog isoform ...
gi|55957491, gi|... - gi|5730041|ref|NP_006695.1| suppressor of G2 allele of SKP1 isoform b [Homo sapiens], gi|55957491|em...
6.0E-70 [55..395] [24..333]

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Predicted Domain #1
Region A:
Residues: [1-54]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVEKDLKTA YKALYDEKEP LKALHLYDEI LKGSPTNLTA LIFKAACLEK LYFG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.221849
Match: 1a17__
Description: Protein phosphatase 5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 6.63746543212322 bayes_pls_golite062009
small conjugating protein ligase activity 6.37753885031863 bayes_pls_golite062009
acid-amino acid ligase activity 5.68162115570289 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 4.89523122092864 bayes_pls_golite062009
binding 2.07985546140154 bayes_pls_golite062009
ligase activity 1.72049482453565 bayes_pls_golite062009
protein binding 1.6279032205159 bayes_pls_golite062009
signal sequence binding 0.0492289984665799 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [55-232]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSDWHSDATM ENAKELLDKA LMTAEGRGDR SKIGLVNFRY FVHFFNIKDY ELAQSYFKKA  60
   61 KNLGYVDDTL PLWEDRLETK LNKKNKKQKD STNKHTIKPV ESIENRGDNN SSHSPISPLK 120
  121 IETAPQESPK FKIDWYQSST SVTISLFTVN LPESKEQVNI YISPNDRRTL SISYQVPK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.045757
Match: 1d8dA_
Description: Protein farnesyltransferase alpha-subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [233-316]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGSEFQYNAK LSHEVDPKAV SLKIFPKKLE ITLSKIDSTQ WKKLEEDILT ESSRLSDEGK  60
   61 NSDSATRLLS AETASKERLS YPSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.30103
Match: 1lg0A_
Description: No description for 1lg0A_ was found.

Predicted Domain #4
Region A:
Residues: [317-395]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKKKIDWSKL DIDEEADEEA GSADSFFQKL YAGADPDTKR AMMKSFIESN GTALSTDWED  60
   61 VSKGTVKTSP PEGMEPKHW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle