YRC Public Data Repository - Protein Structure Prediction

Protein:	SPS19
Organism:	Saccharomyces cerevisiae
Length:	295 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPS19.

Description	E-value	Query Range	Subject Range
gi\|18310052, gi\|... - gi\|18310052\|ref\|NP_561986.1\| 3-ketoacyl-(acyl-carrier-protein) reductase [Clostridium perfringens st...	7.0E-91	[25..273]	[2..246]
FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima GN=fabG PE=3 SV=1 FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / D...	1.0E-90	[24..273]	[2..246]
gi\|25283158 - pir\|\|C83961 3-oxoacyl-(acyl-carrier protein) reductase fabG [imported] - Bacillus halodurans (strain... gi\|10175111, gi\|... - gi\|15615054\|ref\|NP_243357.1\| 3-oxoacyl-(acyl-carrier protein) reductase [Bacillus halodurans C-125],...	2.0E-89	[25..273]	[2..246]
gi\|17232674, gi\|... - gi\|17232674\|ref\|NP_489222.1\| oxidoreductase [Nostoc sp. PCC 7120], gi\|17134321\|dbj\|BAB76881.1\| oxido... gi\|25283433 - pir\|\|AF2453 oxidoreductase alr5182 [imported] - Nostoc sp. (strain PCC 7120)	4.0E-87	[5..275]	[18..285]
TRNH5_ARATH - Tropinone reductase homolog At2g29260, chloroplastic OS=Arabidopsis thaliana GN=At2g29260 PE=2 SV=1	8.0E-87	[5..281]	[43..322]
gi\|1502421 - gi\|1502421\|gb\|AAC44307.1\| 3-ketoacyl-acyl carrier protein reductase gi\|1502421\|gb\|AA... - 3-ketoacyl-acyl carrier protein reductase	3.0E-86	[25..273]	[2..246]
gi\|11498806, gi\|... - gi\|2649386\|gb\|AAB90046.1\| 2-deoxy-D-gluconate 3-dehydrogenase (kduD) [Archaeoglobus fulgidus DSM 430... gi\|7431025 - pir\|\|F69400 2-deoxy-D-gluconate 3-dehydrogenase (kduD) homolog - Archaeoglobus fulgidus	3.0E-86	[2..272]	[18..278]
gi\|221313791 - gi\|221313791\|ref\|ZP_03595596.1\| beta-ketoacyl-acyl carrier protein reductase [Bacillus subtilis subs... gi\|221318715 - gi\|221318715\|ref\|ZP_03600009.1\| beta-ketoacyl-acyl carrier protein reductase [Bacillus subtilis subs... gi\|221322986 - gi\|221322986\|ref\|ZP_03604280.1\| beta-ketoacyl-acyl carrier protein reductase [Bacillus subtilis subs... FABG_BACSU - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Bacillus subtilis GN=fabG PE=3 SV=3 FABG_BACSU - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Bacillus subtilis (strain 168) GN=fabG PE=3 SV=3	6.0E-86	[25..273]	[2..246]
gi\|16800987 - gi\|16800987\|ref\|NP_471255.1\| hypothetical protein lin1921 [Listeria innocua Clip11262] gi\|25283285, gi\|... - pir\|\|AG1672 3-ketoacyl-acyl carrier protein reductase homolog fabG [imported] - Listeria innocua (st...	9.0E-86	[25..273]	[3..247]

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Predicted Domain #1

Region A:
Residues: [1-295]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTMNTANTL DGKFVTEGSW RPDLFKGKVA FVTGGAGTIC RVQTEALVLL GCKAAIVGRD  60
   61 QERTEQAAKG ISQLAKDKDA VLAIANVDVR NFEQVENAVK KTVEKFGKID FVIAGAAGNF 120
  121 VCDFANLSPN AFKSVVDIDL LGSFNTAKAC LKELKKSKGS ILFVSATFHY YGVPFQGHVG 180
  181 AAKAGIDALA KNLAVELGPL GIRSNCIAPG AIDNTEGLKR LAGKKYKEKA LAKIPLQRLG 240
  241 STRDIAESTV YIFSPAASYV TGTVLVVDGG MWHLGTYFGH ELYPEALIKS MTSKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	286.383689
Match:	1gcoA_
Description:	Glucose dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
retinol dehydrogenase activity	4.1750549780559	bayes_pls_golite062009
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	3.06391460989761	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	3.02758902218302	bayes_pls_golite062009
ethanol binding	3.01624801418439	bayes_pls_golite062009
retinol binding	2.89007863838685	bayes_pls_golite062009
L-iditol 2-dehydrogenase activity	2.85461175493562	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	2.66329970371321	bayes_pls_golite062009
benzaldehyde dehydrogenase activity	2.03039843216597	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	1.81060491890041	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
steroid dehydrogenase activity	1.75109362865449	bayes_pls_golite062009
retinoid binding	1.72614743805853	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
isoprenoid binding	1.61095405873981	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.55012034958204	bayes_pls_golite062009
L-arabinitol 2-dehydrogenase activity	1.54130379492877	bayes_pls_golite062009
alcohol binding	1.51091775360793	bayes_pls_golite062009
all-trans retinal binding	1.47861183836779	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
fatty acid synthase activity	1.23679054027553	bayes_pls_golite062009
NADPH:quinone reductase activity	1.19042587095474	bayes_pls_golite062009
sorbose reductase activity	1.06293597394863	bayes_pls_golite062009
binding	0.982999356179965	bayes_pls_golite062009
retinal dehydrogenase activity	0.69372321031969	bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity	0.665447800395781	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	0.65743456407889	bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity	0.604742541607263	bayes_pls_golite062009
DNA binding	0.525227236870065	bayes_pls_golite062009
nucleic acid binding	0.459537641913493	bayes_pls_golite062009
NAD or NADH binding	0.44922383360529	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.439912268968251	bayes_pls_golite062009
coenzyme binding	0.35922330382799	bayes_pls_golite062009
transcription regulator activity	0.177044638410302	bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity	0.124826575912808	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	0.118312276550651	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.0868063468469216	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: