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View Structure Prediction Details

Protein: VPS36
Organism: Saccharomyces cerevisiae
Length: 566 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS36.

Description E-value Query
Range
Subject
Range
VPS36 - Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain w...
gi|207342718 - gi|207342718|gb|EDZ70394.1| YLR417Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190405454 - gi|190405454|gb|EDV08721.1| vacuolar protein sorting protein 36 [Saccharomyces cerevisiae RM11-1a]
VPS36_YEAST - Vacuolar protein-sorting-associated protein 36 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S28...
0.0 [1..566] [1..566]
vps36 - RBZ zinc finger protein Vps36
VPS36_SCHPO - Vacuolar protein-sorting-associated protein 36 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843...
0.0 [6..561] [4..453]
VPS36_MOUSE - Vacuolar protein-sorting-associated protein 36 OS=Mus musculus GN=Vps36 PE=1 SV=1
0.0 [193..561] [36..382]
VPS36_ARATH - Vacuolar protein sorting-associated protein 36 OS=Arabidopsis thaliana GN=VPS36 PE=1 SV=1
0.0 [195..561] [57..411]
gi|109120853, gi... - gi|109120853|ref|XP_001082494.1| PREDICTED: similar to vacuolar protein sorting 36 isoform 2 [Macaca...
gi|10434994 - gi|10434994|dbj|BAB14451.1| unnamed protein product [Homo sapiens]
2.0E-93 [279..561] [1..257]

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Predicted Domain #1
Region A:
Residues: [1-147]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEYWHYVETT SSGQPLLREG EKDIFIDQSV GLYHGKSKIL QRQRGRIFLT SQRIIYIDDA  60
   61 KPTQNSLGLE LDDLAYVNYS SGFLTRSPRL ILFFKDPSSK DELGKSAETA SADVVSTWVC 120
  121 PICMVSNETQ GEFTKDTLPT PICINCG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.95502209146398 bayes_pls_golite062009
DNA binding 4.49877554292304 bayes_pls_golite062009
nucleic acid binding 4.4138116788102 bayes_pls_golite062009
transcription factor activity 3.78905634607011 bayes_pls_golite062009
transcription repressor activity 3.35896772348591 bayes_pls_golite062009
binding 3.09940998297931 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.10135825467854 bayes_pls_golite062009
sequence-specific DNA binding 1.97423148823534 bayes_pls_golite062009
transcription activator activity 1.86787909680028 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
molecular transducer activity 0.574575108509588 bayes_pls_golite062009
signal transducer activity 0.574575108509588 bayes_pls_golite062009
specific transcriptional repressor activity 0.51900654743421 bayes_pls_golite062009
transcription factor binding 0.35726633913804 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.18158516638045 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.136726704233672 bayes_pls_golite062009
small conjugating protein ligase activity 0.118016217031359 bayes_pls_golite062009
structure-specific DNA binding 0.0384502189988831 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [148-566]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPADYELTKS SINCSNAIDP NANPQNQFGV NSENICPACT FANHPQIGNC EICGHRLPNA  60
   61 SKVRSKLNRL NFHDSRVHIE LEKNSLARNK SSHSALSSSS STGSSTEFVQ LSFRKSDGVL 120
  121 FSQATERALE NILTEKNKHI FNQNVVSVNG VDMRKGASSH EYNNEVPFIE TKLSRIGISS 180
  181 LEKSRENQLL NNDILFNNAL TDLNKLMSLA TSIERLYKNS NITMKTKTLN LQDESTVNEP 240
  241 KTRRPLLILD REKFLNKELF LDEIAREIYE FTLSEFKDLN SDTNYMIITL VDLYAMYNKS 300
  301 MRIGTGLISP MEMREACERF EHLGLNELKL VKVNKRILCV TSEKFDVVKE KLVDLIGDNP 360
  361 GSDLLRLTQI LSSNNSKSNW TLGILMEVLQ NCVDEGDLLI DKQLSGIYYY KNSYWPSHI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle