YRC Public Data Repository - Protein Structure Prediction

Protein:	DPS1
Organism:	Saccharomyces cerevisiae
Length:	557 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DPS1.

Description	E-value	Query Range	Subject Range
gi\|207343237 - gi\|207343237\|gb\|EDZ70762.1\| YLL018Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|151941152 - gi\|151941152\|gb\|EDN59530.1\| aspartyl-tRNA synthetase [Saccharomyces cerevisiae YJM789] DPS1 - Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspa... gi\|190406028 - gi\|190406028\|gb\|EDV09295.1\| aspartyl-tRNA synthetase [Saccharomyces cerevisiae RM11-1a] SYDC_YEAST - Aspartate--tRNA ligase, cytoplasmic OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DPS1...	0.0	[1..557]	[1..557]
drs-1 - Aspartyl-tRNA synthetase status:Confirmed UniProt:Q03577 protein_id:CAA79536.1	0.0	[19..557]	[2..531]
SYD_PYRHO - Aspartyl-tRNA synthetase OS=Pyrococcus horikoshii GN=aspS PE=3 SV=1 SYD_PYRHO - Aspartate--tRNA(Asp) ligase OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NB...	0.0	[92..557]	[2..438]
SYD_PYRKO - Aspartyl-tRNA synthetase OS=Pyrococcus kodakaraensis GN=aspS PE=1 SV=2 SYD_THEKO - Aspartate--tRNA(Asp) ligase OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN...	0.0	[92..557]	[2..438]
SYD_PYRAB - Aspartyl-tRNA synthetase OS=Pyrococcus abyssi GN=aspS PE=3 SV=1 SYD_PYRAB - Aspartate--tRNA(Asp) ligase OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=aspS PE=3 SV=1	0.0	[92..557]	[2..438]
gi\|221321410 - gi\|221321410\|ref\|ZP_03602704.1\| lysyl-tRNA synthetase [Bacillus subtilis subsp. subtilis str. SMY] gi\|221317147 - gi\|221317147\|ref\|ZP_03598441.1\| lysyl-tRNA synthetase [Bacillus subtilis subsp. subtilis str. JH642] gi\|221312214 - gi\|221312214\|ref\|ZP_03594019.1\| lysyl-tRNA synthetase [Bacillus subtilis subsp. subtilis str. NCIB 3... SYK_BACSU - Lysine--tRNA ligase OS=Bacillus subtilis (strain 168) GN=lysS PE=3 SV=1 SYK_BACSU - Lysine--tRNA ligase OS=Bacillus subtilis GN=lysS PE=3 SV=1	0.0	[43..554]	[3..499]
gi\|4388836, gi\|4... - gi\|4388837\|pdb\|1B8A\|B Chain B, Aspartyl-Trna Synthetase, gi\|4388836\|pdb\|1B8A\|A Chain A, Aspartyl-Trn... gi\|4388836, gi\|4... - gi\|4388837\|pdb\|1B8A\|B Chain B, Aspartyl-Trna Synthetase, gi\|4388836\|pdb\|1B8A\|A Chain A, Aspartyl-Trn...	0.0	[92..557]	[2..438]
SPCC1223.07c - aspartate-tRNA ligase SYDC_SCHPO - Aspartate--tRNA ligase, cytoplasmic OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=dps1 P...	0.0	[1..557]	[4..580]

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Predicted Domain #1

Region A:
Residues: [1-210]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQDENIVKA VEESAEPAQV ILGEDGKPLS KKALKKLQKE QEKQRKKEER ALQLEAEREA  60
   61 REKKAAAEDT AKDNYGKLPL IQSRDSDRTG QKRVKFVDLD EAKDSDKEVL FRARVHNTRQ 120
  121 QGATLAFLTL RQQASLIQGL VKANKEGTIS KNMVKWAGSL NLESIVLVRG IVKKVDEPIK 180
  181 SATVQNLEIH ITKIYTISET PEALPILLED

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10138.0
Match:	1asyA_
Description:	Aspartyl-tRNA synthetase (AspRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
lysine-tRNA ligase activity	11.0047124677093	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	7.89468709683036	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	7.89468709683036	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	7.88410036819636	bayes_pls_golite062009
ligase activity	6.92073480193262	bayes_pls_golite062009
asparagine-tRNA ligase activity	5.29805946490109	bayes_pls_golite062009
aspartate-tRNA ligase activity	3.80084837437429	bayes_pls_golite062009
phenylalanine-tRNA ligase activity	3.4145644216516	bayes_pls_golite062009
structural constituent of ribosome	2.90150581291897	bayes_pls_golite062009
glycine-tRNA ligase activity	2.61548498770105	bayes_pls_golite062009
structural molecule activity	2.54582212334303	bayes_pls_golite062009
proline-tRNA ligase activity	2.52223115725965	bayes_pls_golite062009
threonine-tRNA ligase activity	2.18642354927	bayes_pls_golite062009
serine-tRNA ligase activity	2.07594942154162	bayes_pls_golite062009
catalytic activity	1.99372273395202	bayes_pls_golite062009
alanine-tRNA ligase activity	1.82594054955281	bayes_pls_golite062009
histidine-tRNA ligase activity	1.72215103383322	bayes_pls_golite062009
transcription regulator activity	1.67362693618722	bayes_pls_golite062009
binding	1.54403712698597	bayes_pls_golite062009
nucleic acid binding	1.48056625237411	bayes_pls_golite062009
DNA binding	1.44496421928708	bayes_pls_golite062009
translation initiation factor activity	1.27539679024898	bayes_pls_golite062009
transcription factor activity	0.825973629967327	bayes_pls_golite062009
sequence-specific DNA binding	0.77755643935497	bayes_pls_golite062009
ribonuclease activity	0.702449673647117	bayes_pls_golite062009
nuclease activity	0.29926900436997	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [211-557]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASRSEAEAEA AGLPVVNLDT RLDYRVIDLR TVTNQAIFRI QAGVCELFRE YLATKKFTEV  60
   61 HTPKLLGAPS EGGSSVFEVT YFKGKAYLAQ SPQFNKQQLI VADFERVYEI GPVFRAENSN 120
  121 THRHMTEFTG LDMEMAFEEH YHEVLDTLSE LFVFIFSELP KRFAHEIELV RKQYPVEEFK 180
  181 LPKDGKMVRL TYKEGIEMLR AAGKEIGDFE DLSTENEKFL GKLVRDKYDT DFYILDKFPL 240
  241 EIRPFYTMPD PANPKYSNSY DFFMRGEEIL SGAQRIHDHA LLQERMKAHG LSPEDPGLKD 300
  301 YCDGFSYGCP PHAGGGIGLE RVVMFYLDLK NIRRASLFPR DPKRLRP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10138.0
Match:	1asyA_
Description:	Aspartyl-tRNA synthetase (AspRS)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: