YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: SCP160
Organism: Saccharomyces cerevisiae
Length: 1222 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SCP160.

Description E-value Query
Range		 Subject
Range
SCP160 - Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear ...
SC160_YEAST - Protein SCP160 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SCP160 PE=1 SV=3
 0.0 [1..1222] [1..1222]
gi|157928314, gi... - gi|168278465|dbj|BAG11112.1| vigilin [synthetic construct], gi|157928314|gb|ABW03453.1| high density...
HDLBP - high density lipoprotein binding protein
 0.0 [13..1219] [2..1193]
VIGLN_MOUSE - Vigilin OS=Mus musculus GN=Hdlbp PE=1 SV=1
 0.0 [13..1219] [2..1193]
VIGLN_RAT - Vigilin OS=Rattus norvegicus GN=Hdlbp PE=1 SV=1
 0.0 [13..1219] [2..1193]
VIGLN_CHICK - Vigilin OS=Gallus gallus GN=HDLBP PE=2 SV=1
 0.0 [13..1219] [2..1195]
CE23530 - high-density lipoprotein-binding protein status:Confirmed UniProt:Q17832 protein_id:CAA91144.2
 0.0 [40..1208] [12..1132]
SPCC550.14 - vigilin
YJVE_SCHPO - KH domain-containing protein C550.14 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC5...
 0.0 [2..1221] [18..1273]

Back

Predicted Domain #1
Region A:
Residues: [1-171] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEEQTAIDS PPSTVEGSVE TVTTIDSPST TASTIAATAE EHPQLEKKPT PLPSLKDLPS  60
   61 LGSNAAFANV KVSWGPNMKP AVSNSPSPSP SAPSLTTGLG AKRMRSKNIQ EAFTLDLQSQ 120
  121 LSITKPELSR IVQSVKKNHD VSVESTLSKN ARTFLVSGVA ANVHEAKREL V

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [172-266] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKLTKPINAV IEVPSKCKAS IIGSGGRTIR EISDAYEVKI NVSKEVNENS YDEDMDDTTS  60
   61 NVSLFGDFES VNLAKAKILA IVKEETKNAT IKLVV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.522879
Match: 1k1gA_
Description: RNA splicing factor 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.12546383654586 bayes_pls_golite062009
nucleic acid binding 3.94829960615623 bayes_pls_golite062009
binding 2.88506305420422 bayes_pls_golite062009
mRNA binding 2.56780637687327 bayes_pls_golite062009
transcription regulator activity 1.92947291634926 bayes_pls_golite062009
DNA binding 1.60641898958006 bayes_pls_golite062009
transcription repressor activity 1.48649836219447 bayes_pls_golite062009
protein binding 1.09698608157472 bayes_pls_golite062009
signal transducer activity 1.00592302262807 bayes_pls_golite062009
molecular transducer activity 1.00592302262807 bayes_pls_golite062009
transcription factor activity 0.693474044974507 bayes_pls_golite062009
catalytic activity 0.1435046019283 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [267-339] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDEKYLPYID VSEFASDEGD EEVKVQFYKK SGDIVILGPR EKAKATKTSI QDYLKKLASN  60
   61 LDEEKVKIPS KFQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.502 0.895 polysome b.40.4 Nucleic acid-binding proteins

Predicted functions:

Term Confidence Notes
RNA binding 4.53756130039297 bayes_pls_golite062009
nucleic acid binding 4.20349765519502 bayes_pls_golite062009
binding 3.03029468866374 bayes_pls_golite062009
mRNA binding 2.96669269799942 bayes_pls_golite062009
transcription regulator activity 1.94297875367222 bayes_pls_golite062009
DNA binding 1.62328996594128 bayes_pls_golite062009
transcription repressor activity 1.56066397370123 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
signal transducer activity 1.00684766673868 bayes_pls_golite062009
molecular transducer activity 1.00684766673868 bayes_pls_golite062009
transcription factor activity 0.687475481524107 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
0.0350881281129536 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [340-417] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLIDAEELKE KYNVIVTFPS TPDDELVSFV GLRDKVGEAI TYARSSSKSY VVESLDISKA  60
   61 HSKNLTHAKN LIMYFTKY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.221849
Match: 1hh2P_
Description: S1 domain of NusA; Transcription factor NusA, C-terminal domains; Transcription factor NusA, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [418-483] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVLKGLEESH PNVKISLPSI QSLPTAETVT IHISAKSDEA NDIKAVRKEL ISFVNNIPPS  60
   61 ETLVIT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.39794
Match: 1e3pA_
Description: Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [484-508] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLDYELFGGS IKHCLLASES SVAFV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [643-701] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANSVARLIGN KGSNLQQIRE KFACQIDIPN EENNNASKDK TVEVTLTGLE YNLTHAKKY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.39794
Match: 1e3pA_
Description: Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural constituent of ribosome 3.83603737358696 bayes_pls_golite062009
transcription regulator activity 3.74935939787001 bayes_pls_golite062009
structural molecule activity 3.27216171079692 bayes_pls_golite062009
nucleic acid binding 1.97035850468348 bayes_pls_golite062009
RNA binding 1.82714562401326 bayes_pls_golite062009
binding 1.5466198129438 bayes_pls_golite062009
transcription termination factor activity 1.53584399356788 bayes_pls_golite062009
DNA binding 1.42930679560452 bayes_pls_golite062009
transcription repressor activity 0.805620048597073 bayes_pls_golite062009
ribonuclease activity 0.621577761289592 bayes_pls_golite062009
transcription factor activity 0.599956044396141 bayes_pls_golite062009
telomeric DNA binding 0.55247451742813 bayes_pls_golite062009
protein binding 0.523813050066193 bayes_pls_golite062009
deacetylase activity 0.446316761887039 bayes_pls_golite062009
ATPase activity 0.368110506118156 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.31569932728929 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.2703049141847 bayes_pls_golite062009
pyrophosphatase activity 0.256048137250105 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.237784820115582 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.235837031080758 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.20814642097724 bayes_pls_golite062009
translation initiation factor activity 0.2080607201312 bayes_pls_golite062009
exoribonuclease activity 0.19299160134668 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.158428921465478 bayes_pls_golite062009
catalytic activity 0.10089766806364 bayes_pls_golite062009
ATPase activity, coupled 0.0992081031610161 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.0481402103729352 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [509-642] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QFGDYYPNDN SILLVALTED EDFKPSIEEI QASLNKANES LNSLRTKQNN METKTYEFSE  60
   61 EVQDSLFKPS SATWKLIMED ISEQEGHLQI KLHTPEENQL TVRGDEKAAK AANKIFESIL 120
  121 NSPSSKSKMT VNIP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [702-849] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAAEAKKWAD IITKELIVPV KFHGSLIGPH GTYRNRLQEK YNVFINFPRD NEIVTIRGPS  60
   61 RGVNKAHEEL KALLDFEMEN GHKMVINVPA EHVPRIIGKN GDNINDIRAE YGVEMDFLQK 120
  121 STDPKAQETG EVELEITGSR QNIKDAAK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.39794
Match: 1e3pA_
Description: Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.12546383654586 bayes_pls_golite062009
nucleic acid binding 3.94829960615623 bayes_pls_golite062009
binding 2.88506305420422 bayes_pls_golite062009
mRNA binding 2.56780637687327 bayes_pls_golite062009
transcription regulator activity 1.92947291634926 bayes_pls_golite062009
DNA binding 1.60641898958006 bayes_pls_golite062009
transcription repressor activity 1.48649836219447 bayes_pls_golite062009
protein binding 1.09698608157472 bayes_pls_golite062009
signal transducer activity 1.00592302262807 bayes_pls_golite062009
molecular transducer activity 1.00592302262807 bayes_pls_golite062009
transcription factor activity 0.693474044974507 bayes_pls_golite062009
catalytic activity 0.1435046019283 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [850-941] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RVESIVAEAS DFVTEVLKID HKYHKSIVGS GGHILREIIS KAGGEEIRNK SVDIPNADSE  60
   61 NKDITVQGPQ KFVKKVVEEI NKIVKDAENS VT

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 11.56
Match: 1khmA
Description: HnRNP K, KH3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.53756130039297 bayes_pls_golite062009
nucleic acid binding 4.20349765519502 bayes_pls_golite062009
binding 3.03029468866374 bayes_pls_golite062009
mRNA binding 2.96669269799942 bayes_pls_golite062009
transcription regulator activity 1.94297875367222 bayes_pls_golite062009
DNA binding 1.62328996594128 bayes_pls_golite062009
transcription repressor activity 1.56066397370123 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
signal transducer activity 1.00684766673868 bayes_pls_golite062009
molecular transducer activity 1.00684766673868 bayes_pls_golite062009
transcription factor activity 0.687475481524107 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
0.0350881281129536 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [942-1010] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTIDIPAERK GALIGPGGIV RRQLESEFNI NLFVPNKDDP SGKITITGAP ENVEKAEKKI  60
   61 LNEIIRENF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.383689
Match: 1vig__
Description: Vigilin, KH6
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural constituent of ribosome 3.72252697400364 bayes_pls_golite062009
nucleic acid binding 3.7132569326175 bayes_pls_golite062009
structural molecule activity 3.13468682204566 bayes_pls_golite062009
DNA binding 3.12689559879854 bayes_pls_golite062009
binding 2.40532042551671 bayes_pls_golite062009
RNA binding 1.76502371106766 bayes_pls_golite062009
transcription regulator activity 1.50283169429524 bayes_pls_golite062009
structure-specific DNA binding 1.10289736160471 bayes_pls_golite062009
single-stranded DNA binding 0.96886436248958 bayes_pls_golite062009
transcription repressor activity 0.805620048597073 bayes_pls_golite062009
transcription factor activity 0.599956044396141 bayes_pls_golite062009
telomeric DNA binding 0.55247451742813 bayes_pls_golite062009
ribonuclease activity 0.498439111185072 bayes_pls_golite062009
sequence-specific DNA binding 0.3506031439435 bayes_pls_golite062009
translation regulator activity 0.31332179848255 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.263197317040851 bayes_pls_golite062009
translation initiation factor activity 0.2080607201312 bayes_pls_golite062009
nuclease activity 0.17660139576327 bayes_pls_golite062009
protein binding 0.152645195799531 bayes_pls_golite062009

Predicted Domain #10
Region A:
Residues: [1011-1082] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DREVDVPASI YEYVSERGAF IQKLRMDLSV NVRFGNTSKK ANKLARAPIE IPLEKVCGST  60
   61 EGENAEKTKF TI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.39794
Match: 1sro__
Description: S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.53756130039297 bayes_pls_golite062009
nucleic acid binding 4.20349765519502 bayes_pls_golite062009
binding 3.03029468866374 bayes_pls_golite062009
mRNA binding 2.96669269799942 bayes_pls_golite062009
transcription regulator activity 1.94297875367222 bayes_pls_golite062009
DNA binding 1.62328996594128 bayes_pls_golite062009
transcription repressor activity 1.56066397370123 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
signal transducer activity 1.00684766673868 bayes_pls_golite062009
molecular transducer activity 1.00684766673868 bayes_pls_golite062009
transcription factor activity 0.687475481524107 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
0.0350881281129536 bayes_pls_golite062009

Predicted Domain #11
Region A:
Residues: [1083-1148] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEVGAPTSSE EGDITMRLTY EPIDLSSILS DGEEKEVTKD TSNDSAKKEE ALDTAVKLIK  60
   61 ERIAKA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.045757
Match: 1j4wA_
Description: Far upstream binding element, FBP, KH3 and KH4 domains
Matching Structure (courtesy of the PDB):

Predicted Domain #12
Region A:
Residues: [1149-1222] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSATYAGYVW GADTRRFNMI VGPGGSNIKK IREAADVIIN VPRKSDKVND VVYIRGTKAG  60
   61 VEKAGEMVLK SLRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.045757
Match: 1j4wA_
Description: Far upstream binding element, FBP, KH3 and KH4 domains
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle