YRC Public Data Repository - Protein Structure Prediction

Protein:	GPA1
Organism:	Saccharomyces cerevisiae
Length:	472 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GPA1.

Description	E-value	Query Range	Subject Range
GPA1 - GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negat... GPA1_YEAST - Guanine nucleotide-binding protein alpha-1 subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 /...	0.0	[1..472]	[1..472]
GNAI_PATPE - Guanine nucleotide-binding protein G(i) subunit alpha OS=Patiria pectinifera PE=1 SV=3	0.0	[126..471]	[8..353]
GNAI1_RAT, GBI1_RAT - (P10824) Guanine nucleotide-binding protein G(i), alpha-1 subunit (Adenylate cyclase-inhibiting G al... gi\|999973, gi\|13... - gi\|999973\|pdb\|1GFI\| Chain , Guanine Nucleotide-Binding Protein G(I), Alpha-1 Subunit (G(I)-Alpha-1...	0.0	[126..471]	[7..352]
gi\|5650709 - gi\|5650709\|emb\|CAB43212.2\| hypothetical protein [Homo sapiens] gi\|117646132 - gi\|117646132\|emb\|CAL38533.1\| hypothetical protein [synthetic construct]	0.0	[126..471]	[8..353]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[126..471]	[8..353]
GNAI1_CAVPO - Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Cavia porcellus GN=GNAI1 PE=2 SV=3	0.0	[126..471]	[8..353]

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Predicted Domain #1

Region A:
Residues: [1-146]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGCTVSTQTI GDESDPFLQN KRANDVIEQS LQLEKQRDKN EIKLLLLGAG ESGKSTVLKQ  60
   61 LKLLHQGGFS HQERLQYAQV IWADAIQSMK ILIIQARKLG IQLDCDDPIN NKDLFACKRI 120
  121 LLKAKALDYI NASVAGGSDF LNDYVL

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	5.823909
Match:	PF00503
Description:	G-protein alpha subunit

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [147-472]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KYSERYETRR RVQSTGRAKA AFDEDGNISN VKSDTDRDAE TVTQNEDADR NNSSRINLQD  60
   61 ICKDLNQEGD DQMFVRKTSR EIQGQNRRNL IHEDIAKAIK QLWNNDKGIK QCFARSNEFQ 120
  121 LEGSAAYYFD NIEKFASPNY VCTDEDILKG RIKTTGITET EFNIGSSKFK VLDAGGQRSE 180
  181 RKKWIHCFEG ITAVLFVLAM SEYDQMLFED ERVNRMHESI MLFDTLLNSK WFKDTPFILF 240
  241 LNKIDLFEEK VKSMPIRKYF PDYQGRVGDA EAGLKYFEKI FLSLNKTNKP IYVKRTCATD 300
  301 TQTMKFVLSA VTDLIIQQNL KKIGII

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1559.0
Match:	1scgA_
Description:	No description for 1scgA_ was found.

Predicted functions:

Term	Confidence	Notes
GTPase activity	4.92902654551215	bayes_pls_golite062009
microtubule motor activity	3.80749143568847	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.4837867129694	bayes_pls_golite062009
ion transmembrane transporter activity	3.35436118751376	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
cation transmembrane transporter activity	3.08390071341252	bayes_pls_golite062009
opioid receptor binding	3.0590320138875	bayes_pls_golite062009
mu-type opioid receptor binding	3.0590320138875	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
primary active transmembrane transporter activity	2.61775212528604	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.61467977505707	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.57552435627908	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.57107347424517	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.57054427875021	bayes_pls_golite062009
active transmembrane transporter activity	2.50494515048649	bayes_pls_golite062009
microfilament motor activity	2.50080241360447	bayes_pls_golite062009
ATPase activity, coupled	2.43862163407966	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.40292717311506	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
motor activity	2.32425703346903	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.26365379756656	bayes_pls_golite062009
binding	2.21604035604783	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	2.1115517127743	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
G-protein coupled receptor activity	1.63949223587737	bayes_pls_golite062009
G-protein-coupled receptor binding	1.59603802863121	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.58971273330352	bayes_pls_golite062009
hydrolase activity	1.57549510726226	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.4343912580786	bayes_pls_golite062009
actin-dependent ATPase activity	1.24861649961991	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.23799860254751	bayes_pls_golite062009
cation channel activity	0.997064416395892	bayes_pls_golite062009
purine nucleotide binding	0.929901285538132	bayes_pls_golite062009
nucleotide binding	0.922442819194247	bayes_pls_golite062009
purine ribonucleotide binding	0.920987930180051	bayes_pls_golite062009
ribonucleotide binding	0.920926158369519	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.767424210804186	bayes_pls_golite062009
voltage-gated cation channel activity	0.688632087597536	bayes_pls_golite062009
molecular transducer activity	0.683309012097319	bayes_pls_golite062009
signal transducer activity	0.683309012097319	bayes_pls_golite062009
transmembrane receptor activity	0.661834961742057	bayes_pls_golite062009
guanyl nucleotide binding	0.656009904481476	bayes_pls_golite062009
guanyl ribonucleotide binding	0.64416740142962	bayes_pls_golite062009
GTP binding	0.643084645864898	bayes_pls_golite062009
calcium channel activity	0.636216614902039	bayes_pls_golite062009
receptor activity	0.633514002718998	bayes_pls_golite062009
voltage-gated channel activity	0.562664200036023	bayes_pls_golite062009
voltage-gated ion channel activity	0.559798751382976	bayes_pls_golite062009
plus-end-directed microtubule motor activity	0.471293810042041	bayes_pls_golite062009
anion transmembrane transporter activity	0.43332053110728	bayes_pls_golite062009
ATP binding	0.41092997612902	bayes_pls_golite062009
drug transmembrane transporter activity	0.38711726712063	bayes_pls_golite062009
adenyl ribonucleotide binding	0.385813421701492	bayes_pls_golite062009
adenyl nucleotide binding	0.377870145186619	bayes_pls_golite062009
potassium channel activity	0.329290830676079	bayes_pls_golite062009
gated channel activity	0.299411774392227	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	0.248918847596573	bayes_pls_golite062009
nucleic acid binding	0.194779852865789	bayes_pls_golite062009
metabotropic serotonin receptor binding	0.178039386254807	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
ion channel activity	0.154779598791225	bayes_pls_golite062009
passive transmembrane transporter activity	0.134817721656507	bayes_pls_golite062009
channel activity	0.134817721656507	bayes_pls_golite062009
substrate-specific channel activity	0.126911677161968	bayes_pls_golite062009
voltage-gated calcium channel activity	0.0789800146503108	bayes_pls_golite062009
cation-transporting ATPase activity	0.0536898657672154	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	0.0122470146764899	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: