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View Structure Prediction Details

Protein: SLX8
Organism: Saccharomyces cerevisiae
Length: 274 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SLX8.

Description E-value Query
Range
Subject
Range
gi|151944832 - gi|151944832|gb|EDN63091.1| conserved protein [Saccharomyces cerevisiae YJM789]
gi|207345874 - gi|207345874|gb|EDZ72555.1| YER116Cp-like protein [Saccharomyces cerevisiae AWRI1631]
SLX8_YEAST - E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8 OS=Saccharomyces cerevisiae (strain ATCC ...
SLX8 - Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachm...
gi|190405678 - gi|190405678|gb|EDV08945.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
7.0E-44 [1..264] [1..264]
PUB14_ARATH - U-box domain-containing protein 14 OS=Arabidopsis thaliana GN=PUB14 PE=1 SV=1
2.0E-33 [1..268] [40..311]
gi|14042062 - gi|14042062|dbj|BAB55092.1| unnamed protein product [Homo sapiens]
1.0E-30 [1..263] [654..900]
gi|16198151 - gi|16198151|gb|AAL13880.1| LD35285p [Drosophila melanogaster]
7.0E-27 [1..263] [358..605]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-26 [9..253] [382..609]

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Predicted Domain #1
Region A:
Residues: [1-198]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARRPDNQNP EGENLRIKRV RLESVRQNDE EEENEVSRTQ NIVTDNRHDS PEAVVEIIGE  60
   61 RALENTSEED GDDDLSLFRA LEEDPGSDHN TSNNDSGNHD RETMHTEEPE ASSGNNITLT 120
  121 NNVEELHTMD VLSQTANTPS ASPMLDAAPP TTKPGTNSKE QTVDLTADAI DLDAEEQQVL 180
  181 QISDDDFQEE TKEAPKEY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [199-274]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAAKDYRCPI CFEPPETALM TLCGHVFCCP CLFQMVNSSR TCRQFGHCAL CRSKVYLKDV  60
   61 RLIILRKKQV KKKVKS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.30103
Match: 1jm7A_
Description: brca1 RING domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 10.2497392096259 bayes_pls_golite062009
small conjugating protein ligase activity 10.0460587929138 bayes_pls_golite062009
acid-amino acid ligase activity 8.99384576623969 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 7.6988425139962 bayes_pls_golite062009
ligase activity 3.92677358871643 bayes_pls_golite062009
binding 2.58862749918018 bayes_pls_golite062009
protein binding 1.49775478023418 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.2126425713931 bayes_pls_golite062009
ubiquitin-specific protease activity 1.03469202541773 bayes_pls_golite062009
transcription regulator activity 0.919313413645213 bayes_pls_golite062009
nucleic acid binding 0.894017701424745 bayes_pls_golite062009
DNA binding 0.588609879350932 bayes_pls_golite062009
cysteine-type peptidase activity 0.50197530717959 bayes_pls_golite062009
ubiquitin thiolesterase activity 0.265769062717221 bayes_pls_golite062009
transcription factor binding 0.14168789797081 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle