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View Structure Prediction Details

Protein: SIZ1
Organism: Saccharomyces cerevisiae
Length: 904 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SIZ1.

Description E-value Query
Range
Subject
Range
SIZ1 - SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to p...
SIZ1_YEAST - E3 SUMO-protein ligase SIZ1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SIZ1 PE=1 SV...
0.0 [1..904] [1..904]
gi|157929196, gi... - gi|157929196|gb|ABW03883.1| protein inhibitor of activated STAT, 2 [synthetic construct], gi|1239998...
gi|3643113, gi|2... - gi|3643113|gb|AAC36704.1| protein inhibitor of activated STAT protein PIASx-alpha [Homo sapiens], gi...
0.0 [26..508] [3..490]
gi|16758050, gi|... - gi|4176737|gb|AAD13349.1| androgen receptor interacting protein; ARIP [Rattus norvegicus], gi|167580...
0.0 [26..508] [3..490]
gi|13542785 - gi|13542785|gb|AAH05596.1| Protein inhibitor of activated STAT 2 [Mus musculus]
0.0 [33..508] [1..481]

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Predicted Domain #1
Region A:
Residues: [1-106]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MINLEDYWED ETPGPDREPT NELRNEVEET ITLMELLKVS ELKDICRSVS FPVSGRKAVL  60
   61 QDLIRNFLQN ALVVGKSDPY RVQAVKFLIE RIRKNEPLPV YKDLWN

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 10.236572
Match: PF02037
Description: SAP domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
SUMO ligase activity 7.09211721404578 bayes_pls_golite062009
small conjugating protein ligase activity 5.19208367271658 bayes_pls_golite062009
acid-amino acid ligase activity 4.23914967265256 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 2.74673402515898 bayes_pls_golite062009
binding 2.26662406320154 bayes_pls_golite062009
protein binding 1.60046728943053 bayes_pls_golite062009
nucleic acid binding 1.45346081057303 bayes_pls_golite062009
DNA binding 1.3220534257427 bayes_pls_golite062009
transcription regulator activity 1.24563554819776 bayes_pls_golite062009
transcription factor binding 0.6524624181863 bayes_pls_golite062009
transcription cofactor activity 0.55208373081056 bayes_pls_golite062009
catalytic activity 0.454272578060498 bayes_pls_golite062009
ligase activity 0.36302660895622 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.11065840905983 bayes_pls_golite062009
nuclear hormone receptor binding 0.0906176057893404 bayes_pls_golite062009
steroid hormone receptor binding 0.0808240821039099 bayes_pls_golite062009
transcription activator activity 0.0459673376823702 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [107-219]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALRKGTPLSA ITVRSMEGPP TVQQQSPSVI RQSPTQRRKT STTSSTSRAP PPTNPDASSS  60
   61 SSSFAVPTIH FKESPFYKIQ RLIPELVMNV EVTGGRGMCS AKFKLSKADY NLL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [220-289]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNPNSKHRLY LFSGMINPLG SRGNEPIQFP FPNELRCNNV QIKDNIRGFK SKPGTAKPAD  60
   61 LTPHLKPYTQ 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [290-410]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNNVELIYAF TTKEYKLFGY IVEMITPEQL LEKVLQHPKI IKQATLLYLK KTLREDEEMG  60
   61 LTTTSTIMSL QCPISYTRMK YPSKSINCKH LQCFDALWFL HSQLQIPTWQ CPVCQIDIAL 120
  121 E

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 33.60206
Match: PF02891
Description: MIZ zinc finger

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [411-529]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLAISEFVDD ILQNCQKNVE QVELTSDGKW TAILEDDDDS DSDSNDGSRS PEKGTSVSDH  60
   61 HCSSSHPSEP IIINLDSDDD EPNGNNPHVT NNHDDSNRHS NDNNNNSIKN NDSHNKNNN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [530-904]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNNNNNNNNN DNNNSIENND SNSNNKHDHG SRSNTPSHNH TKNLMNDNDD DDDDRLMAEI  60
   61 TSNHLKSTNT DILTEKGSSA PSRTLDPKSY NIVASETTTP VTNRVIPEYL GNSSSYIGKQ 120
  121 LPNILGKTPL NVTAVDNSSH LISPDVSVSS PTPRNTASNA SSSALSTPPL IRMSSLDPRG 180
  181 STVPDKTIRP PINSNSYTAS ISDSFVQPQE SSVFPPREQN MDMSFPSTVN SRFNDPRLNT 240
  241 TRFPDSTLRG ATILSNNGLD QRNNSLPTTE AITRNDVGRQ NSTPVLPTLP QNVPIRTNSN 300
  301 KSGLPLINNE NSVPNPPNTA TIPLQKSRLI VNPFIPRRPY SNVLPQKRQL SNTSSTSPIM 360
  361 GTWKTQDYGK KYNSG

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.34
Match: 1i3qA
Description: RBP1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle