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View Structure Prediction Details

Protein: SFA1
Organism: Saccharomyces cerevisiae
Length: 386 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SFA1.

Description E-value Query
Range		 Subject
Range
ADHX_SPAAU - Alcohol dehydrogenase class-3 OS=Sparus aurata PE=2 SV=1
 0.0 [5..382] [3..376]
ADH1_PETHY - Alcohol dehydrogenase 1 OS=Petunia hybrida GN=ADH1 PE=1 SV=1
 0.0 [1..383] [1..381]
gi|2570190 - gi|2570190|dbj|BAA22979.1| alcohol dehydrogenase [Arabidopsis thaliana]
 0.0 [4..382] [2..377]
gi|1297359 - gi|1297359|gb|AAA98984.1| alcohol dehydrogenase 2d [Gossypium hirsutum]
 0.0 [4..384] [2..379]
gi|6684357 - gi|6684357|gb|AAF23539.1|AF110441_1 alcohol dehydrogenase [Halimolobos perplexa var. lemhiensis]
 0.0 [4..382] [2..377]
ADHX_SAAHA - Alcohol dehydrogenase class-3 OS=Saara hardwickii PE=1 SV=1
 0.0 [9..382] [4..373]
gi|6684364 - gi|6684364|gb|AAF23546.1|AF110448_1 alcohol dehydrogenase [Arabis lyallii]
 0.0 [4..382] [2..377]
gi|2570182, gi|2... - gi|2570182|dbj|BAA22976.1| alcohol dehydrogenase [Arabidopsis halleri subsp. gemmifera], gi|2570176|...
 0.0 [4..382] [2..377]

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Predicted Domain #1
Region A:
Residues: [1-181] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAATVGKPI KCIAAVAYDA KKPLSVEEIT VDAPKAHEVR IKIEYTAVCH TDAYTLSGSD  60
   61 PEGLFPCVLG HEGAGIVESV GDDVITVKPG DHVIALYTAE CGKCKFCTSG KTNLCGAVRA 120
  121 TQGKGVMPDG TTRFHNAKGE DIYHFMGCST FSEYTVVADV SVVAIDPKAP LDAACLLGCG 180
  181 V

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [330-386] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKGRSEMGGL IKDYQKGALK VEEFITHRRP FKEINQAFED LHNGDCLRTV LKSDEIK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1411.0
Match: 1tehA_
Description: Alcohol dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ethanol binding 4.47659026306883 bayes_pls_golite062009
NAD or NADH binding 4.35058438816264 bayes_pls_golite062009
retinol dehydrogenase activity 4.1750549780559 bayes_pls_golite062009
oxidoreductase activity 3.09625241707629 bayes_pls_golite062009
L-iditol 2-dehydrogenase activity 3.00103406168296 bayes_pls_golite062009
alcohol binding 2.97042200128883 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 2.94416173750168 bayes_pls_golite062009
retinol binding 2.89007863838685 bayes_pls_golite062009
all-trans retinal binding 2.84803957533249 bayes_pls_golite062009
S-(hydroxymethyl)glutathione dehydrogenase activity 2.58673703881996 bayes_pls_golite062009
hydroxymethylfurfural reductase (NADH) activity 2.2999175117758 bayes_pls_golite062009
hydroxymethylfurfural reductase activity 2.2999175117758 bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent 2.26153457113968 bayes_pls_golite062009
NADPH:quinone reductase activity 2.16668841986245 bayes_pls_golite062009
benzaldehyde dehydrogenase activity 2.03039843216597 bayes_pls_golite062009
catalytic activity 1.79741889688267 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 1.65338499044318 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.47309297191111 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 1.29842732066898 bayes_pls_golite062009
chaperone binding 1.19079350615542 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 1.01627645289834 bayes_pls_golite062009
binding 0.784517759335365 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors 0.62461633437589 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.527946013169731 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.484089941059577 bayes_pls_golite062009
kinase activity 0.461063813999598 bayes_pls_golite062009
hydroxymethylfurfural reductase (NADPH) activity 0.382131941157781 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.375415252607746 bayes_pls_golite062009
coenzyme binding 0.35922330382799 bayes_pls_golite062009
protein kinase activity 0.339420053437627 bayes_pls_golite062009
nucleic acid binding 0.274019118261823 bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity 0.233238483713519 bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity 0.169301675015808 bayes_pls_golite062009
DNA binding 0.164288600669795 bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity 0.162625185692811 bayes_pls_golite062009
fatty acid synthase activity 0.0962368786590111 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [182-329] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTGFGAALKT ANVQKGDTVA VFGCGTVGLS VIQGAKLRGA SKIIAIDINN KKKQYCSQFG  60
   61 ATDFVNPKED LAKDQTIVEK LIEMTDGGLD FTFDCTGNTK IMRDALEACH KGWGQSIIIG 120
  121 VAAAGEEIST RPFQLVTGRV WKGSAFGG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1411.0
Match: 1tehA_
Description: Alcohol dehydrogenase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle