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View Structure Prediction Details

Protein: SLX5
Organism: Saccharomyces cerevisiae
Length: 619 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SLX5.

Description E-value Query
Range
Subject
Range
SLX5 - Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified...
SLX5_YEAST - E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5 OS=Saccharomyces cerevisiae (strain ATCC ...
gi|151941979 - gi|151941979|gb|EDN60335.1| conserved protein [Saccharomyces cerevisiae YJM789]
gi|190405032 - gi|190405032|gb|EDV08299.1| hypothetical protein SCRG_00519 [Saccharomyces cerevisiae RM11-1a]
0.0 [1..619] [1..619]

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Predicted Domain #1
Region A:
Residues: [1-619]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHSDTNGRTK SNNSPSDNNP NETVILIDSD KEEDASIREA NLPVRLYPDR RVGRRRDALN  60
   61 RFVRSDSRSR NSQRTHITAS SERPDFQANN DDITIIREVG RFFGDDGPID PSAHYVDLDQ 120
  121 EPGSETLETP RTIQVDNTNG YLNDNGNNNE SDDGLTIVEE RTTRPRVTLN LPGGERLEVT 180
  181 ATTTDIPIRR SFEFQEDLGA SRRQLLRRSA TRARNLFVDR SDENDEDWTD DTHNLPEAIQ 240
  241 RARRESRMRM SRRIAERQRR VQQQRVSSDE NISTSIRLQS IRERIQSYTP DIRSAFHRAE 300
  301 SLHEFRSILQ NVAPITLQEC EEELMALFTE FRNQLLQNWA IDRVRNTQEE ALRLHREALE 360
  361 RQERTAGRVF HRGTLRESIT NYLNFNGEDG FLSRLWSGPA LSDADEERHT QNIIDMIQER 420
  421 EERERDVVMK NLMNKTRAQQ EEFEARAASL PEGYSASFDT TPKMKLDITK NGKEETIIVT 480
  481 DDDLAKTLED IPVCCLCGAE LGVGIPDDFT GISQKDRGVS FEGLVSKYKF HCPYQTLARP 540
  541 SMLDRDLSKR TFIASCGHAF CGRCFARIDN AKKKSKMPKK KLAQLKGSAH PDNYGPKLCP 600
  601 ADSCKKLIRS RGRLKEVYF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [129-224]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPRTIQVDNT NGYLNDNGNN NESDDGLTIV EERTTRPRVT LNLPGGERLE VTATTTDIPI  60
   61 RRSFEFQEDL GASRRQLLRR SATRARNLFV DRSDEN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [225-400]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEDWTDDTHN LPEAIQRARR ESRMRMSRRI AERQRRVQQQ RVSSDENIST SIRLQSIRER  60
   61 IQSYTPDIRS AFHRAESLHE FRSILQNVAP ITLQECEEEL MALFTEFRNQ LLQNWAIDRV 120
  121 RNTQEEALRL HREALERQER TAGRVFHRGT LRESITNYLN FNGEDGFLSR LWSGPA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [401-619]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSDADEERHT QNIIDMIQER EERERDVVMK NLMNKTRAQQ EEFEARAASL PEGYSASFDT  60
   61 TPKMKLDITK NGKEETIIVT DDDLAKTLED IPVCCLCGAE LGVGIPDDFT GISQKDRGVS 120
  121 FEGLVSKYKF HCPYQTLARP SMLDRDLSKR TFIASCGHAF CGRCFARIDN AKKKSKMPKK 180
  181 KLAQLKGSAH PDNYGPKLCP ADSCKKLIRS RGRLKEVYF

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.21
Match: 1zbdB
Description: Effector domain of rabphilin-3a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
small conjugating protein ligase activity 6.54419701634876 bayes_pls_golite062009
acid-amino acid ligase activity 5.81081610285635 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 4.98431511196461 bayes_pls_golite062009
binding 2.64299129598715 bayes_pls_golite062009
histone binding 2.18177552065219 bayes_pls_golite062009
ligase activity 1.77976870053311 bayes_pls_golite062009
protein binding 1.22943142958169 bayes_pls_golite062009
DNA binding 1.19418339248022 bayes_pls_golite062009
nucleic acid binding 1.16305426959673 bayes_pls_golite062009
transcription regulator activity 1.03976333752272 bayes_pls_golite062009
chromatin binding 0.880691867408093 bayes_pls_golite062009
methylated histone residue binding 0.635303636820801 bayes_pls_golite062009
protein kinase activity 0.408714103048697 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.152196493675947 bayes_pls_golite062009
transcription factor activity 0.124593950007804 bayes_pls_golite062009
lysine N-acetyltransferase activity 0.108887977080526 bayes_pls_golite062009
histone acetyltransferase activity 0.108887977080526 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.0912529186589195 bayes_pls_golite062009
kinase activity 0.00873885939655655 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle