| Protein: | Eph-PD |
| Organism: | Drosophila melanogaster |
| Length: | 1080 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Eph-PD.
| Description | E-value | Query Range |
Subject Range |
|
|
1029.0 | [0..1] | [1071..1] |
|
Region A: Residues: [1-79] |
1 11 21 31 41 51
| | | | | |
1 MKMVGCHPND KKVKYDGIKS KTSSVTILTS VLNDAISALK SAFYKNQAPI SEQNRSQIVS 60
61 RMSLLRTILL IIISIHFKL
|
| Detection Method: |  |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [80-320] |
1 11 21 31 41 51
| | | | | |
1 AHADQVVLLD TTREATLEWT RYPYGPQAQT PGWVEESFTD FVKGINWRSY VVCDVAYHNV 60
61 NNWLWSPFID RGSANRLYIE IQFTIRDCSL FPGNALSCKE TFSLLFYEFD AATREPPPWQ 120
121 TDSYRLIARI AAGEGRFNQN SDVDINTEVK SIAVNKKGVY FAFRDQGACI SVLAVKVYYI 180
181 TCPAVTENFA HFNETPTGRE ITIIEKQNGT CVDNAEPYET PTYLCKGDGK WTILTGGCRC 240
241 K
|
| Detection Method: | |
| Confidence: | 83.0 |
| Match: | 1nukA |
| Description: | Ligand-binding domain of the ephb2 receptor tyrosine kinase |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| integrin binding | 3.61193098087012 | bayes_pls_golite062009 |
| transmembrane receptor activity | 2.80879825615822 | bayes_pls_golite062009 |
| receptor activity | 2.77268648576901 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 2.47762337031838 | bayes_pls_golite062009 |
| binding | 2.31774167130542 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 2.23073603832866 | bayes_pls_golite062009 |
| phosphatidylserine binding | 2.22270974208755 | bayes_pls_golite062009 |
| molecular transducer activity | 2.03595043486636 | bayes_pls_golite062009 |
| signal transducer activity | 2.03595043486636 | bayes_pls_golite062009 |
| protein binding | 1.90867517664953 | bayes_pls_golite062009 |
| fucose binding | 1.72607684089801 | bayes_pls_golite062009 |
| protein kinase activity | 1.70755634087208 | bayes_pls_golite062009 |
| monosaccharide binding | 1.62596107035359 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.39122779055629 | bayes_pls_golite062009 |
| kinase activity | 1.31546222648513 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.28997154411534 | bayes_pls_golite062009 |
| carbohydrate binding | 1.26743933952271 | bayes_pls_golite062009 |
| vascular endothelial growth factor receptor activity | 1.21634643105777 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 1.18833031215069 | bayes_pls_golite062009 |
| sugar binding | 1.1562287794497 | bayes_pls_golite062009 |
| glycoprotein binding | 0.68697655195721 | bayes_pls_golite062009 |
| protein complex binding | 0.56054373949313 | bayes_pls_golite062009 |
| nucleic acid binding | 0.533285414042183 | bayes_pls_golite062009 |
| transferase activity | 0.530643564656921 | bayes_pls_golite062009 |
| receptor binding | 0.365344483970243 | bayes_pls_golite062009 |
| DNA binding | 0.324772578014229 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 0.24891369301653 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 0.16022291279782 | bayes_pls_golite062009 |
| phosphatidylethanolamine binding | 0.121022714964449 | bayes_pls_golite062009 |
|
Region A: Residues: [321-677] |
1 11 21 31 41 51
| | | | | |
1 AGYEPNYTNK TCTECPLGTF KSPEVTKCTP CPPNSNASKT GSPFCKCASG FYRHPNDGRH 60
61 MPCYSPPAAP TNLTLLFVDQ TSAIISWSAP AKNESFSSET NSKIYHSDIV YKIKCNICSP 120
121 NVVYNPSTDT FNETKITLTN LEPVTTYTVQ IHAINSVSHI NEFKRHSNES SLVAVSDIVF 180
181 SNTSLLNIPL DLNEVKTGQA EIVFTTESVL LSTVFNLRIL AITNKDADLE WDKPVQSDFP 240
241 LEFYEVRWFP KVELDAINKS ALNTKETKAH IVGLLENTEY GFQVRCKTNN GFGSYSNMIY 300
301 AQTLQSVGSV YDDSVQIRFI AGAIVTGVLF LVIFIIATVY FMRSKHQDDL DKKSTNH
|
| Detection Method: | |
| Confidence: | 13.045757 |
| Match: | 2dtgE |
| Description: | No description for 2dtgE was found. |
| Term | Confidence | Notes |
| cytokine receptor activity | 6.1064338595335 | bayes_pls_golite062009 |
| transmembrane receptor activity | 4.81256300373074 | bayes_pls_golite062009 |
| receptor activity | 4.66147271961356 | bayes_pls_golite062009 |
| cytokine binding | 4.43581512268554 | bayes_pls_golite062009 |
| growth factor binding | 4.06808996928726 | bayes_pls_golite062009 |
| molecular transducer activity | 3.69234048247377 | bayes_pls_golite062009 |
| signal transducer activity | 3.69234048247377 | bayes_pls_golite062009 |
| ciliary neurotrophic factor receptor activity | 3.63249501085562 | bayes_pls_golite062009 |
| interleukin-6 binding | 3.43159399159985 | bayes_pls_golite062009 |
| interleukin-6 receptor activity | 3.43159399159985 | bayes_pls_golite062009 |
| protein binding | 3.24522318184038 | bayes_pls_golite062009 |
| binding | 3.12471204223368 | bayes_pls_golite062009 |
| interleukin-11 binding | 2.34894404420874 | bayes_pls_golite062009 |
| interleukin-11 receptor activity | 2.34894404420874 | bayes_pls_golite062009 |
| ciliary neurotrophic factor binding | 2.27923575030525 | bayes_pls_golite062009 |
| prolactin receptor activity | 2.15346920063421 | bayes_pls_golite062009 |
| growth hormone receptor activity | 2.12450488436659 | bayes_pls_golite062009 |
| peptide hormone binding | 2.12033076929638 | bayes_pls_golite062009 |
| SH2 domain binding | 2.08068947938928 | bayes_pls_golite062009 |
| axon guidance receptor activity | 2.01367445237355 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 1.91712452737778 | bayes_pls_golite062009 |
| integrin binding | 1.91458191628393 | bayes_pls_golite062009 |
| leukemia inhibitory factor receptor activity | 1.74022530568614 | bayes_pls_golite062009 |
| oncostatin-M receptor activity | 1.74022530568614 | bayes_pls_golite062009 |
| insulin binding | 1.70967279462923 | bayes_pls_golite062009 |
| polysaccharide binding | 1.69642470905172 | bayes_pls_golite062009 |
| interleukin-2 binding | 1.67132604890013 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 1.6158868405814 | bayes_pls_golite062009 |
| ciliary neurotrophic factor receptor binding | 1.49133343034886 | bayes_pls_golite062009 |
| cytokine receptor binding | 1.47680672146246 | bayes_pls_golite062009 |
| protein kinase activity | 1.42856560840953 | bayes_pls_golite062009 |
| heparin binding | 1.40418056272895 | bayes_pls_golite062009 |
| receptor binding | 1.31676259534833 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.15899955607967 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.12142142875217 | bayes_pls_golite062009 |
| kinase activity | 1.11027658115625 | bayes_pls_golite062009 |
| cell surface binding | 1.05599555585797 | bayes_pls_golite062009 |
| peptide binding | 0.92031154055894 | bayes_pls_golite062009 |
| interleukin-2 receptor activity | 0.894667058714949 | bayes_pls_golite062009 |
| protein dimerization activity | 0.86564366658585 | bayes_pls_golite062009 |
| actin filament binding | 0.848221254225135 | bayes_pls_golite062009 |
| PTB domain binding | 0.76001954410963 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.703490254739121 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.657804692814791 | bayes_pls_golite062009 |
| ankyrin binding | 0.56921114104552 | bayes_pls_golite062009 |
| identical protein binding | 0.564711394496051 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 0.554350228628563 | bayes_pls_golite062009 |
| transcription activator activity | 0.529736394173061 | bayes_pls_golite062009 |
| nucleic acid binding | 0.522840770355105 | bayes_pls_golite062009 |
| hormone binding | 0.49524185948356 | bayes_pls_golite062009 |
| peptidase activator activity | 0.47985796351505 | bayes_pls_golite062009 |
| transcription regulator activity | 0.470959482317512 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 0.46168925186147 | bayes_pls_golite062009 |
| transferase activity | 0.432850266451294 | bayes_pls_golite062009 |
| DNA binding | 0.310798383307903 | bayes_pls_golite062009 |
| interleukin-7 binding | 0.301052531308189 | bayes_pls_golite062009 |
| insulin receptor activity | 0.216119401508389 | bayes_pls_golite062009 |
| transcription factor binding | 0.210682741845199 | bayes_pls_golite062009 |
| mercury ion binding | 0.180077451915479 | bayes_pls_golite062009 |
| pattern binding | 0.16768253393396 | bayes_pls_golite062009 |
| protein heterodimerization activity | 0.1430595594485 | bayes_pls_golite062009 |
| protein homodimerization activity | 0.116391819218123 | bayes_pls_golite062009 |
| growth factor activity | 0.0477008672713168 | bayes_pls_golite062009 |
|
Region A: Residues: [678-1015] |
1 11 21 31 41 51
| | | | | |
1 LPLPLDYASN EVNSMDTTPI VKKLHLNVTT PLFGNSRSYV DPHTYEDPNQ AIREFAREID 60
61 ANYITIEAII GGGEFGDVCR GRLKIPPNFV QDIDVAIKTL KPGSSEKARC DFLTEASIMG 120
121 QFDHPNVIYL QGVVTRSNPV MIITEYMENG SLDTFLRVND GKFQTLQLIV MLRGIASGMS 180
181 YLSDMNYVHR DLAARNVLVN AQLICKIADF GLSREIENAS DAYTTRGGKI PVRWTAPEAI 240
241 AFRKFTSASD VWSYGVVLWE VMSYGERPYW NWSNQDVIKS IEKGYRLPAP MDCPEALYQL 300
301 MLDCWQKQRT HRPTFASIVS TLDNLARQPQ SLLTTRPS
|
| Detection Method: | |
| Confidence: | 75.39794 |
| Match: | 1jpaA |
| Description: | ephb2 receptor tyrosine kinase |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| protein kinase activity | 5.4586557943719 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 5.04467222534257 | bayes_pls_golite062009 |
| kinase activity | 4.85903980916957 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.63692708178478 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 3.43994026029707 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 3.41480681854114 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 3.40140621607334 | bayes_pls_golite062009 |
| transferase activity | 3.26787750561728 | bayes_pls_golite062009 |
| transmembrane receptor activity | 3.1965684217331 | bayes_pls_golite062009 |
| receptor activity | 2.96273889901429 | bayes_pls_golite062009 |
| molecular transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| signal transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 2.8153155526437 | bayes_pls_golite062009 |
| binding | 2.74863538127007 | bayes_pls_golite062009 |
| growth factor binding | 2.61235080252818 | bayes_pls_golite062009 |
| insulin binding | 2.37668498690029 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 2.1677218320705 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 2.1677218320705 | bayes_pls_golite062009 |
| receptor signaling protein activity | 2.10379226653669 | bayes_pls_golite062009 |
| SH2 domain binding | 2.08937039830657 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 1.81249386965144 | bayes_pls_golite062009 |
| acetylcholine receptor activator activity | 1.71667135325509 | bayes_pls_golite062009 |
| non-membrane spanning protein tyrosine kinase activity | 1.66669268613198 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| integrin binding | 1.44154155381408 | bayes_pls_golite062009 |
| PTB domain binding | 1.2635189297467 | bayes_pls_golite062009 |
| activin binding | 1.22461306010416 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| insulin receptor activity | 0.974517002259609 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 0.95914323793919 | bayes_pls_golite062009 |
| fibroblast growth factor 1 binding | 0.881001697574359 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type I | 0.880236579821909 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| activin receptor activity | 0.811117252475389 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 0.75189004129952 | bayes_pls_golite062009 |
| transporter activity | 0.710766490066447 | bayes_pls_golite062009 |
| actin filament binding | 0.66248865719696 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 0.610230065465794 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.60324822483033 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 0.499492353295369 | bayes_pls_golite062009 |
| protein kinase C activity | 0.41587987561486 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.385603245903806 | bayes_pls_golite062009 |
| 3-phosphoinositide-dependent protein kinase binding | 0.372842462336059 | bayes_pls_golite062009 |
| JUN kinase kinase kinase kinase activity | 0.349343975617553 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 0.294256794094724 | bayes_pls_golite062009 |
| transforming growth factor beta binding | 0.287757704969289 | bayes_pls_golite062009 |
| kinase binding | 0.26752427107238 | bayes_pls_golite062009 |
| protein complex binding | 0.239339759110451 | bayes_pls_golite062009 |
| polysaccharide binding | 0.229808864843639 | bayes_pls_golite062009 |
| glutamate receptor binding | 0.208072372526169 | bayes_pls_golite062009 |
| cytokine binding | 0.17817111033393 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.152203945257581 | bayes_pls_golite062009 |
| activin receptor activity, type I | 0.117759584117941 | bayes_pls_golite062009 |
| protein kinase binding | 0.00674998152095019 | bayes_pls_golite062009 |
|
Region A: Residues: [1016-1080] |
1 11 21 31 41 51
| | | | | |
1 PESDGNHILD GQRGQNIFIS TDLWLEHIKM SRYCHHFKEA NLINAQQVNS SNYHFCINQF 60
61 FIVKY
|
| Detection Method: | |
| Confidence: | 82.39794 |
| Match: | 2qoqA |
| Description: | No description for 2qoqA was found. |
