YRC Public Data Repository - Protein Structure Prediction

Protein:	GLNA_ECOLI
Organism:	Escherichia coli
Length:	469 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GLNA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|21730907, gi\|... - gi\|21730914\|pdb\|2GLS\|L Chain L, Refined Atomic Model Of Glutamine Synthetase At 3.5 Angstroms Resolu... gi\|21730911\|pdb\|... - Chain H, Refined Atomic Model Of Glutamine Synthetase At 3.5 Angstroms Resolution, Chain G, Refined ...	591.0	[0..1]	[469..1]
gi\|194435178, gi... - gi\|83568944\|ref\|ZP_00920410.1\| COG0174: Glutamine synthetase [Shigella dysenteriae 1012], gi\|1944351...	590.0	[0..1]	[469..1]
GLNA_SALTI - Glutamine synthetase OS=Salmonella typhi GN=glnA PE=3 SV=2 gi\|29143913, gi\|... - gi\|29143913\|ref\|NP_807255.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Typhi... gi\|16762425 - gi\|16762425\|ref\|NP_458042.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Typhi... GLNA_SALTI - Glutamine synthetase OS=Salmonella typhi GN=glnA PE=3 SV=2 GLNA_SALTY - Glutamine synthetase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=glnA PE=1 SV... GLNA_SALTY - Glutamine synthetase OS=Salmonella typhimurium GN=glnA PE=1 SV=2 gi\|56415853, gi\|... - gi\|56415853\|ref\|YP_152928.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Parat... gi\|167551514, gi... - gi\|205323728\|gb\|EDZ11567.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Saintp... GLNA_SALTY - Glutamine synthetase OS=Salmonella typhimurium GN=glnA PE=1 SV=2 gi\|205327139, gi... - gi\|205327139\|gb\|EDZ13903.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar 4,[5],... gi\|168232931, gi... - gi\|205332792\|gb\|EDZ19556.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Kentuc... gi\|168237622, gi... - gi\|197289412\|gb\|EDY28777.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Schwar... gi\|238912151 - gi\|238912151\|ref\|ZP_04655988.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Te... gi\|161617130, gi... - gi\|161617130\|ref\|YP_001591095.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar P... gi\|62182469, gi\|... - gi\|62182469\|ref\|YP_218886.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Chole... gi\|200387082, gi... - gi\|200387082\|ref\|ZP_03213694.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Vi... gi\|204930303, gi... - gi\|204930303\|ref\|ZP_03221280.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Ja... gi\|206711002, gi... - gi\|207859199\|ref\|YP_002245850.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar E... gi\|213162859 - gi\|213162859\|ref\|ZP_03348569.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Ty... gi\|197214496, gi... - gi\|197250793\|ref\|YP_002148926.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar A... gi\|197243065, gi... - gi\|197264810\|ref\|ZP_03164884.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Sa... gi\|197364783, gi... - gi\|197364783\|ref\|YP_002144420.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar P... gi\|197937374, gi... - gi\|198242858\|ref\|YP_002217928.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar D... gi\|194446331, gi... - gi\|194446331\|ref\|YP_002043229.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar N... gi\|194450350, gi... - gi\|194450350\|ref\|YP_002048010.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar H... gi\|194470420, gi... - gi\|194470420\|ref\|ZP_03076404.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Ke... gi\|194736881, gi... - gi\|194736881\|ref\|YP_002116927.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar S... gi\|205336868, gi... - gi\|205336868\|gb\|EDZ23632.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Heidel... gi\|205348216, gi... - gi\|205348216\|gb\|EDZ34847.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Hadar ... gi\|168467337, gi... - gi\|195630254\|gb\|EDX48894.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Newpor... gi\|168821657, gi... - gi\|205341806\|gb\|EDZ28570.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Weltev... gi\|224585817, gi... - gi\|224585817\|ref\|YP_002639616.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar P... gi\|213425467 - gi\|213425467\|ref\|ZP_03358217.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Ty... lcl\|NC_016856.1_... - [gene=glnA] [protein=glutamine synthetase] [protein_id=YP_005240273.1] [location=complement(4229183.... gi\|213616220 - gi\|213616220\|ref\|ZP_03372046.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Ty... gi\|213852015 - gi\|213852015\|ref\|ZP_03381547.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Ty... gi\|214002900 - gi\|214002900\|ref\|ZP_03413635.1\| glutamine synthetase [Salmonella enterica subsp. enterica serovar Ty...	589.0	[0..1]	[469..1]
gi\|12518749, gi\|... - gi\|15804455\|ref\|NP_290495.1\| glutamine synthetase [Escherichia coli O157:H7 EDL933], gi\|12518749\|gb\|... gi\|25293493 - gi\|25293493\|pir\|\|G86074 glutamine synthetase [imported] - Escherichia coli (strain O157:H7, substrai...	589.0	[0..1]	[469..1]
gi\|3808290 - gi\|3808290\|gb\|AAC69320.1\| glutamine synthetase [Enterobacter gergoviae]	584.0	[0..1]	[469..1]
gi\|146157 - gi\|146157\|gb\|AAA23879.1\| glutamine synthetase [Escherichia coli]	583.0	[0..1]	[469..1]
gi\|49609518, gi\|... - gi\|50118992\|ref\|YP_048159.1\| glutamine synthetase [Pectobacterium atrosepticum SCRI1043], gi\|4960951...	581.0	[0..1]	[469..1]
gi\|23630225 - gi\|23630225\|gb\|AAN37400.1\| glutamine synthetase [Pantoea agglomerans]	581.0	[0..1]	[469..1]

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Predicted Domain #1

Region A:
Residues: [1-469]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAEHVLTML NEHEVKFVDL RFTDTKGKEQ HVTIPAHQVN AEFFEEGKMF DGSSIGGWKG  60
   61 INESDMVLMP DASTAVIDPF FADSTLIIRC DILEPGTLQG YDRDPRSIAK RAEDYLRSTG 120
  121 IADTVLFGPE PEFFLFDDIR FGSSISGSHV AIDDIEGAWN SSTQYEGGNK GHRPAVKGGY 180
  181 FPVPPVDSAQ DIRSEMCLVM EQMGLVVEAH HHEVATAGQN EVATRFNTMT KKADEIQIYK 240
  241 YVVHNVAHRF GKTATFMPKP MFGDNGSGMH CHMSLSKNGV NLFAGDKYAG LSEQALYYIG 300
  301 GVIKHAKAIN ALANPTTNSY KRLVPGYEAP VMLAYSARNR SASIRIPVVS SPKARRIEVR 360
  361 FPDPAANPYL CFAALLMAGL DGIKNKIHPG EAMDKNLYDL PPEEAKEIPQ VAGSLEEALN 420
  421 ELDLDREFLK AGGVFTDEAI DAYIALRREE DDRVRMTPHP VEFELYYSV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	169.0
Match:	2glsA
Description:	Glutamine synthetase, N-terminal domain; Glutamine synthetase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ammonia ligase activity	6.27241182807427	bayes_pls_golite062009
acid-ammonia (or amide) ligase activity	5.91942691148686	bayes_pls_golite062009
ligase activity	1.87132312522382	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	1.62421495628324	bayes_pls_golite062009
catalytic activity	1.08973967683802	bayes_pls_golite062009
binding	0.98415932762563	bayes_pls_golite062009
nucleic acid binding	0.873840044936337	bayes_pls_golite062009
protein binding	0.232967538442099	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: