YRC Public Data Repository - Protein Structure Prediction

Protein:	END8_ECOLI
Organism:	Escherichia coli
Length:	263 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for END8_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|193070399, gi... - gi\|75234793\|ref\|ZP_00719096.1\| COG0266: Formamidopyrimidine-DNA glycosylase [Escherichia coli E11001...	343.0	[0..1]	[262..1]
FPG_SHISS - Formamidopyrimidine-DNA glycosylase OS=Shigella sonnei (strain Ss046) GN=mutM PE=3 SV=3 gi\|124530495, gi... - gi\|124530495\|ref\|ZP_01701122.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli B], gi\|1244991... FPG_ECOLC - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=mu... FPG_ECO45 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=mutM PE=3 SV=... FPG_SHIBS - Formamidopyrimidine-DNA glycosylase OS=Shigella boydii serotype 4 (strain Sb227) GN=mutM PE=3 SV=3 FPG_ECO81 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O81 (strain ED1a) GN=mutM PE=3 SV=1 gi\|75242586, gi\|... - gi\|75242586\|ref\|ZP_00726330.1\| COG0266: Formamidopyrimidine-DNA glycosylase [Escherichia coli F11], ... FPG_ECOLU - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=mutM ... gi\|188487129, gi... - gi\|75514303\|ref\|ZP_00736611.1\| COG0266: Formamidopyrimidine-DNA glycosylase [Escherichia coli 53638]... gi\|15833764, gi\|... - gi\|15833764\|ref\|NP_312537.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. Saka... FPG_SHIF8 - Formamidopyrimidine-DNA glycosylase OS=Shigella flexneri serotype 5b (strain 8401) GN=mutM PE=3 SV=1 gi\|56480390, gi\|... - gi\|56480390\|ref\|NP_709414.2\| formamidopyrimidine-DNA glycosylase [Shigella flexneri 2a str. 301], gi... gi\|208814029, gi... - gi\|208814029\|ref\|ZP_03255358.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. E... gi\|208820753, gi... - gi\|208820753\|ref\|ZP_03261073.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. E... FPG_ECO5E - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=mutM PE=3 ... FPG_ECOSE - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli (strain SE11) GN=mutM PE=3 SV=1 FPG_ECO24 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=mutM PE=... FPG_ECO27 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=mutM PE=... gi\|191167823, gi... - gi\|75229026\|ref\|ZP_00715610.1\| COG0266: Formamidopyrimidine-DNA glycosylase [Escherichia coli B7A], ... gi\|217324519, gi... - gi\|217324519\|ref\|ZP_03440603.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. T... gi\|194430989, gi... - gi\|83571421\|ref\|ZP_00922861.1\| COG0266: Formamidopyrimidine-DNA glycosylase [Shigella dysenteriae 10... FPG_ESCF3 - Formamidopyrimidine-DNA glycosylase OS=Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0... FPG_SHIB3 - Formamidopyrimidine-DNA glycosylase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=m... FPG_ECO8A - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O8 (strain IAI1) GN=mutM PE=3 SV=1 FPG_SHIFL - Formamidopyrimidine-DNA glycosylase OS=Shigella flexneri GN=mutM PE=3 SV=3 gi\|254795590, gi... - gi\|254795590\|ref\|YP_003080427.1\| formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glyco... gi\|254038834, gi... - gi\|254038834\|ref\|ZP_04872886.1\| formamidopyrimidine-DNA glycosylase [Escherichia sp. 1_1_43], gi\|226... gi\|226902669, gi... - gi\|237703405\|ref\|ZP_04533886.1\| formamidopyrimidine-DNA glycosylase [Escherichia sp. 3_2_53FAA], gi\|... FPG_ECO57 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O157:H7 GN=mutM PE=3 SV=3 sp\|B7ULJ0\|FPG_ECO27 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=mutM PE=... gi\|168753459, gi... - gi\|189358964\|gb\|EDU77383.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. EC440... gi\|189369599, gi... - gi\|189369599\|gb\|EDU88015.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. EC450... gi\|189364460, gi... - gi\|189364460\|gb\|EDU82879.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. EC448... gi\|168772399, gi... - gi\|187771367\|gb\|EDU35211.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. EC419... gi\|189002553, gi... - gi\|189002553\|gb\|EDU71539.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. EC407... gi\|189374639, gi... - gi\|189374639\|gb\|EDU93055.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. EC869... FPG_ECOSM - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=mutM PE=3 SV=1 gi\|195936196 - gi\|195936196\|ref\|ZP_03081578.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. E... FPG_ECOUT - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli (strain UTI89 / UPEC) GN=mutM PE=3 SV=1 gi\|30065089, gi\|... - gi\|30065089\|ref\|NP_839260.1\| formamidopyrimidine-DNA glycosylase [Shigella flexneri 2a str. 2457T], ... gi\|209754676, gi... - pir\|\|G86039 formamidopyrimidine DNA glycosylase [imported] - Escherichia coli (strain O157:H7, subst... gi\|15804176, gi\|... - gi\|15804176\|ref\|NP_290215.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 EDL933], ... FPG_ECOK1 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O1:K1 / APEC GN=mutM PE=3 SV=1 gi\|188016969, gi... - gi\|188016969\|gb\|EDU55091.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. EC411...	342.0	[0..1]	[262..1]
FPG_ECOL6 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O6 GN=mutM PE=3 SV=3 FPG_ECOL6 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) G... gi\|227883803, gi... - gi\|227883803\|ref\|ZP_04001608.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli 83972], gi\|227...	341.0	[0..1]	[262..1]
FPG_ECOL5 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=mutM PE=3 ...	340.0	[0..1]	[262..1]
FPG_SHIDS - Formamidopyrimidine-DNA glycosylase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=mutM PE=3 S...	340.0	[0..1]	[262..1]
FPG_ECODH - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli (strain K12 / DH10B) GN=mutM PE=3 SV=1 EG10329 - formamidopyrimidine /5-formyluracil / 5-hydroxymethyluracil DNA glycosylase / Formamidopyrimidine-DNA ... FPG_ECOBW - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=mutM PE=3 ... gi\|242379159, gi... - gi\|251786886\|ref\|YP_003001190.1\| hypothetical protein B21_03444 [Escherichia coli BL21], gi\|24237915... gi\|253771524, gi... - gi\|254290313\|ref\|YP_003056061.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli BL21(DE3)], g... gi\|254163563, gi... - gi\|254163563\|ref\|YP_003046671.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli B str. REL606... gi\|83588518, gi\|... - gi\|83588518\|ref\|ZP_00927142.1\| COG0266: Formamidopyrimidine-DNA glycosylase [Escherichia coli 101-1]... FPG_ECOLI - Formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) (Fapy-DNA glycosylase) (DNA-(apurinic or apyrimidi... FPG_ECOHS - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O9:H4 (strain HS) GN=mutM PE=3 SV=1 EG10329 - formamidopyrimidine /5-formyluracil / 5-hydroxymethyluracil DNA glycosylase / Formamidopyrimidine-DNA ... gi\|85676407, gi\|... - gi\|89110376\|ref\|AP_004156.1\| formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosyla...	340.0	[0..1]	[262..1]
gi\|193063825, gi... - gi\|75258175\|ref\|ZP_00729623.1\| COG0266: Formamidopyrimidine-DNA glycosylase [Escherichia coli E22], ... gi\|75208028, gi\|... - gi\|75208028\|ref\|ZP_00708440.1\| COG0266: Formamidopyrimidine-DNA glycosylase [Escherichia coli B171],... FPG_ECO55 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli (strain 55989 / EAEC) GN=mutM PE=3 SV=1	339.0	[0..1]	[262..1]
gi\|238722313, gi... - gi\|77972446\|ref\|ZP_00828012.1\| COG0266: Formamidopyrimidine-DNA glycosylase [Yersinia frederiksenii ...	337.0	[0..1]	[263..1]
FPG_SALTY - Formamidopyrimidine-DNA glycosylase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) ... FPG_SALHS - Formamidopyrimidine-DNA glycosylase OS=Salmonella heidelberg (strain SL476) GN=mutM PE=3 SV=1 FPG_SALTY - Formamidopyrimidine-DNA glycosylase OS=Salmonella typhimurium GN=mutM PE=3 SV=3 gi\|167994347, gi... - gi\|205327810\|gb\|EDZ14574.1\| formamidopyrimidine-DNA glycosylase [Salmonella enterica subsp. enterica... gi\|205338984, gi... - gi\|205338984\|gb\|EDZ25748.1\| formamidopyrimidine-DNA glycosylase [Salmonella enterica subsp. enterica... gi\|205350455, gi... - gi\|205350455\|gb\|EDZ37086.1\| formamidopyrimidine-DNA glycosylase [Salmonella enterica subsp. enterica... lcl\|NC_016856.1_... - [gene=mutM] [protein=formamidopyrimidine-DNA glycosylase] [protein_id=YP_005239968.1] [location=comp... FPG_SALTY - Formamidopyrimidine-DNA glycosylase OS=Salmonella typhimurium GN=mutM PE=3 SV=3	337.0	[0..1]	[262..1]
FPG_PHOPR - Formamidopyrimidine-DNA glycosylase OS=Photobacterium profundum (strain SS9) GN=mutM PE=3 SV=3 FPG_PHOPR - Formamidopyrimidine-DNA glycosylase OS=Photobacterium profundum GN=mutM PE=3 SV=3	336.0	[0..1]	[262..1]

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Predicted Domain #1

Region A:
Residues: [1-263]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPEGPEIRRA ADNLEAAIKG KPLTDVWFAF PQLKPYQSQL IGQHVTHVET RGKALLTHFS  60
   61 NDLTLYSHNQ LYGVWRVVDT GEEPQTTRVL RVKLQTADKT ILLYSASDIE MLTPEQLTTH 120
  121 PFLQRVGPDV LDPNLTPEVV KERLLSPRFR NRQFAGLLLD QAFLAGLGNY LRVEILWQVG 180
  181 LTGNHKAKDL NAAQLDALAH ALLEIPRFSY ATRGQVDENK HHGALFRFKV FHRDGEPCER 240
  241 CGSIIEKTTL SSRPFYWCPG CQH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	68.09691
Match:	1k3wA
Description:	Endonuclease VIII
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA N-glycosylase activity	4.06377793944255	bayes_pls_golite062009
oxidized base lesion DNA N-glycosylase activity	3.68895100180378	bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds	3.63831813037192	bayes_pls_golite062009
oxidized purine base lesion DNA N-glycosylase activity	3.50273405950314	bayes_pls_golite062009
DNA-(apurinic or apyrimidinic site) lyase activity	3.32722481172627	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	2.59048389792519	bayes_pls_golite062009
hydrolase activity	1.74627738237592	bayes_pls_golite062009
binding	1.7313696856499	bayes_pls_golite062009
DNA binding	1.22619720972604	bayes_pls_golite062009
nucleic acid binding	1.17199530230795	bayes_pls_golite062009
transcription regulator activity	1.16376707327858	bayes_pls_golite062009
protein binding	1.14219782236887	bayes_pls_golite062009
transcription factor activity	0.472763834470731	bayes_pls_golite062009
catalytic activity	0.101795606736461	bayes_pls_golite062009
lyase activity	0.0836281676510939	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: