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View Structure Prediction Details

Protein: HGNC:3720|MIM:60...
Organism: SPECIES UNKNOWN
Length: 459 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HGNC:3720|MIM:60....

Description E-value Query
Range		 Subject
Range
gi|109474286 - gi|109474286|ref|XP_001066628.1| PREDICTED: similar to FK506-binding protein 4 (Peptidyl-prolyl cis-...
 4.0E-61 [1..459] [155..612]
gi|57106584 - gi|57106584|ref|XP_534923.1| PREDICTED: similar to FK506-binding protein 4 (Peptidyl-prolyl cis-tran...
 6.0E-58 [1..459] [1..459]
gi|109095077 - gi|109095077|ref|XP_001098079.1| PREDICTED: FK506-binding protein 4 isoform 2 [Macaca mulatta]
 1.0E-57 [1..459] [1..459]
gi|60825929, gi|... - gi|60825929|gb|AAX36740.1| FK506 binding protein 4 [synthetic construct], gi|60653315|gb|AAX29352.1|...
 2.0E-57 [1..459] [1..459]
FKBP4_MOUSE - Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Mus musculus GN=Fkbp4 PE=1 SV=5
gi|55249913 - gb|AAH86118.1| Unknown (protein for MGC:98518) [Xenopus laevis]
 7.0E-57 [1..459] [1..458]
FKBP4_RABIT - Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Oryctolagus cuniculus GN=FKBP4 PE=1 SV=3
 3.0E-55 [1..459] [1..458]

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Predicted Domain #1
Region A:
Residues: [1-118] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAEEMKATE SGAQSAPLPM EGVDISPKQD EGVLKVIKRE GTGTEMPMIG DRVFVHYTGW  60
   61 LLDGTKFDSS LDRKDKFSFD LGKGEVIKAW DIAIATMKVG EVCHITCKPE YAYGSAGS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.69897
Match: 1n1aA
Description: FKBP52, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ryanodine-sensitive calcium-release channel activity 10.9968443145942 bayes_pls_golite062009
intracellular ligand-gated calcium channel activity 10.9968443145942 bayes_pls_golite062009
macrolide binding 7.31599503004442 bayes_pls_golite062009
FK506 binding 7.22442625476031 bayes_pls_golite062009
metal ion transmembrane transporter activity 6.74926751944787 bayes_pls_golite062009
calcium channel activity 6.4374377859142 bayes_pls_golite062009
cation channel activity 6.06732269872248 bayes_pls_golite062009
ion channel activity 5.45007096522107 bayes_pls_golite062009
passive transmembrane transporter activity 5.32426176964634 bayes_pls_golite062009
channel activity 5.32426176964634 bayes_pls_golite062009
substrate-specific channel activity 5.28960420749143 bayes_pls_golite062009
gated channel activity 5.28074654906904 bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity 4.0615867467963 bayes_pls_golite062009
cis-trans isomerase activity 3.99265212272703 bayes_pls_golite062009
ligand-gated channel activity 3.34717828007833 bayes_pls_golite062009
ligand-gated ion channel activity 3.34717828007833 bayes_pls_golite062009
ion transmembrane transporter activity 2.6566793500337 bayes_pls_golite062009
cation transmembrane transporter activity 2.61794461605199 bayes_pls_golite062009
calcium-release channel activity 2.58969194870156 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.47257819150887 bayes_pls_golite062009
isomerase activity 2.31710030777753 bayes_pls_golite062009
transcription regulator activity 1.85589011277711 bayes_pls_golite062009
receptor activity 1.78361575899771 bayes_pls_golite062009
transmembrane receptor activity 1.7459556028988 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.68688812199737 bayes_pls_golite062009
kinase activity 1.67904764195462 bayes_pls_golite062009
binding 1.63170667962375 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.57898291235576 bayes_pls_golite062009
signal transducer activity 1.53711974553033 bayes_pls_golite062009
molecular transducer activity 1.53711974553033 bayes_pls_golite062009
protein kinase activity 1.45320632553313 bayes_pls_golite062009
drug binding 1.39643621593407 bayes_pls_golite062009
transferase activity 1.34122735969662 bayes_pls_golite062009
receptor serine/threonine kinase binding 1.32709321745178 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 1.32470025150272 bayes_pls_golite062009
transforming growth factor beta receptor binding 1.32470025150272 bayes_pls_golite062009
transporter activity 1.25197125648774 bayes_pls_golite062009
protein binding 1.08765413491791 bayes_pls_golite062009
SMAD binding 1.04905381164355 bayes_pls_golite062009
transmembrane transporter activity 1.03909235910355 bayes_pls_golite062009
catalytic activity 0.885282592863018 bayes_pls_golite062009
substrate-specific transporter activity 0.789390402522536 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.763739321802433 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.763739321802433 bayes_pls_golite062009
intracellular ligand-gated ion channel activity 0.727019445105701 bayes_pls_golite062009
protein serine/threonine kinase activity 0.671059013500415 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.525950701946406 bayes_pls_golite062009
unfolded protein binding 0.27473817613726 bayes_pls_golite062009
activin binding 0.262691232876501 bayes_pls_golite062009
histone binding 0.221748741603068 bayes_pls_golite062009
transcription elongation regulator activity 0.21145105012677 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [119-316] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPKIPPNATL VFEVELFEFK GEDLTEEEDG GIIRRIQTRG EGYAKPNEGA IVEVALEGYY  60
   61 KDKLFDQREL RFEIGEGENL DLPYGLERAI QRMEKGEHSI VYLKPSYAFG SVGKEKFQIP 120
  121 PNAELKYELH LKSFEKAKES WEMNSEEKLE QSTIVKERGT VYFKEGKYKQ ALLQYKKIVS 180
  181 WLEYESSFSN EEAQKAQA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.95
Match: 1kt0A
Description: FKBP51, C-terminal domain; FKBP51, N-terminal domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ryanodine-sensitive calcium-release channel activity 10.5818680850178 bayes_pls_golite062009
intracellular ligand-gated calcium channel activity 10.5818680850178 bayes_pls_golite062009
macrolide binding 6.76364038125885 bayes_pls_golite062009
metal ion transmembrane transporter activity 6.73398709732238 bayes_pls_golite062009
FK506 binding 6.68168417220699 bayes_pls_golite062009
procollagen-proline 4-dioxygenase activity 6.33141891074556 bayes_pls_golite062009
procollagen-proline dioxygenase activity 6.33141891074556 bayes_pls_golite062009
peptidyl-proline dioxygenase activity 6.33141891074556 bayes_pls_golite062009
peptidyl-proline 4-dioxygenase activity 6.33141891074556 bayes_pls_golite062009
calcium channel activity 6.26093539961789 bayes_pls_golite062009
cation channel activity 6.02454701753153 bayes_pls_golite062009
protein phosphatase 2A binding 5.70177601384074 bayes_pls_golite062009
ion channel activity 5.41446659728328 bayes_pls_golite062009
channel activity 5.29566611694414 bayes_pls_golite062009
passive transmembrane transporter activity 5.29566611694414 bayes_pls_golite062009
substrate-specific channel activity 5.25915730995039 bayes_pls_golite062009
gated channel activity 5.23693345098661 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors 4.40754649831781 bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity 3.47347683498372 bayes_pls_golite062009
cis-trans isomerase activity 3.41272339669823 bayes_pls_golite062009
ligand-gated channel activity 3.27653035675626 bayes_pls_golite062009
ligand-gated ion channel activity 3.27653035675626 bayes_pls_golite062009
ion transmembrane transporter activity 2.66103271426565 bayes_pls_golite062009
cation transmembrane transporter activity 2.61980214265117 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.48031953795714 bayes_pls_golite062009
phosphatase activity 2.44706583719107 bayes_pls_golite062009
phosphoric ester hydrolase activity 2.38926130931194 bayes_pls_golite062009
ubiquitin-protein ligase activity 2.32557041601016 bayes_pls_golite062009
calcium-release channel activity 2.24272229394245 bayes_pls_golite062009
small conjugating protein ligase activity 2.09150703279726 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.08144339124986 bayes_pls_golite062009
isomerase activity 1.92777278447686 bayes_pls_golite062009
transcription regulator activity 1.83171242300949 bayes_pls_golite062009
receptor activity 1.78786100885722 bayes_pls_golite062009
transmembrane receptor activity 1.75042985427656 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.6949579078176 bayes_pls_golite062009
kinase activity 1.68748031932496 bayes_pls_golite062009
binding 1.66926716799278 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.58792227723443 bayes_pls_golite062009
signal transducer activity 1.54949624451448 bayes_pls_golite062009
molecular transducer activity 1.54949624451448 bayes_pls_golite062009
phosphoprotein phosphatase activity 1.48932763287956 bayes_pls_golite062009
protein kinase activity 1.4606316161198 bayes_pls_golite062009
acid-amino acid ligase activity 1.42907226857237 bayes_pls_golite062009
transferase activity 1.35149948487544 bayes_pls_golite062009
DNA binding 1.32823848889363 bayes_pls_golite062009
transporter activity 1.26515051009051 bayes_pls_golite062009
receptor serine/threonine kinase binding 1.25364237438323 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 1.24715902371406 bayes_pls_golite062009
transforming growth factor beta receptor binding 1.24715902371406 bayes_pls_golite062009
steroid hormone receptor binding 1.1910515648311 bayes_pls_golite062009
protein binding 1.13205057608753 bayes_pls_golite062009
transmembrane transporter activity 1.05129296782391 bayes_pls_golite062009
nucleic acid binding 1.03214696367403 bayes_pls_golite062009
drug binding 1.02692887826597 bayes_pls_golite062009
heat shock protein binding 0.974870566753586 bayes_pls_golite062009
SMAD binding 0.923832336018678 bayes_pls_golite062009
transcription activator activity 0.865375739926993 bayes_pls_golite062009
catalytic activity 0.838457647933563 bayes_pls_golite062009
transcription repressor activity 0.831782705534701 bayes_pls_golite062009
substrate-specific transporter activity 0.7991885026596 bayes_pls_golite062009
hormone receptor binding 0.7429757196483 bayes_pls_golite062009
nuclear hormone receptor binding 0.713457194766522 bayes_pls_golite062009
transcription factor activity 0.679223944174373 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.679185625455585 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.679185625455585 bayes_pls_golite062009
protein serine/threonine kinase activity 0.676568185178303 bayes_pls_golite062009
protein serine/threonine phosphatase activity 0.620169189588866 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 0.599036230630856 bayes_pls_golite062009
intracellular ligand-gated ion channel activity 0.547008204307472 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 0.513111849696122 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.510792404154917 bayes_pls_golite062009
enzyme binding 0.335436488591595 bayes_pls_golite062009
unfolded protein binding 0.23321005341344 bayes_pls_golite062009
transcription factor binding 0.202402797164729 bayes_pls_golite062009
hydrolase activity 0.191714540920279 bayes_pls_golite062009
histone binding 0.187349169865552 bayes_pls_golite062009
activin binding 0.155745749643662 bayes_pls_golite062009
signal sequence binding 0.144756387712192 bayes_pls_golite062009
superoxide-generating NADPH oxidase activity 0.0442139417921878 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [317-459] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRLASHLNLA MCHLKLQAFS AAIESCNKAL ELDSNNEKGL FRRGEAHLAV NDFELARADF  60
   61 QKVLQLYPNN KAAKTQLAVC QQRIRRQLAR EKKLYANMFE RLAEEENKAK AEASSGDHPT 120
  121 DTEMKEEQKS NTAGSQSQVE TEA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.30103
Match: 1qz2A
Description: Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
intracellular ligand-gated calcium channel activity 10.9968443145942 bayes_pls_golite062009
ryanodine-sensitive calcium-release channel activity 10.9968443145942 bayes_pls_golite062009
macrolide binding 7.31599503004442 bayes_pls_golite062009
FK506 binding 7.22442625476031 bayes_pls_golite062009
peptidyl-proline dioxygenase activity 6.80616214194201 bayes_pls_golite062009
procollagen-proline dioxygenase activity 6.80616214194201 bayes_pls_golite062009
peptidyl-proline 4-dioxygenase activity 6.80616214194201 bayes_pls_golite062009
procollagen-proline 4-dioxygenase activity 6.80616214194201 bayes_pls_golite062009
metal ion transmembrane transporter activity 6.74926751944787 bayes_pls_golite062009
calcium channel activity 6.4374377859142 bayes_pls_golite062009
cation channel activity 6.06732269872248 bayes_pls_golite062009
protein phosphatase 2A binding 6.03345119957353 bayes_pls_golite062009
ion channel activity 5.45007096522107 bayes_pls_golite062009
channel activity 5.32426176964634 bayes_pls_golite062009
passive transmembrane transporter activity 5.32426176964634 bayes_pls_golite062009
substrate-specific channel activity 5.28960420749143 bayes_pls_golite062009
gated channel activity 5.28074654906904 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors 4.77770372249654 bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity 4.0615867467963 bayes_pls_golite062009
cis-trans isomerase activity 3.99265212272703 bayes_pls_golite062009
ligand-gated ion channel activity 3.34717828007833 bayes_pls_golite062009
ligand-gated channel activity 3.34717828007833 bayes_pls_golite062009
ion transmembrane transporter activity 2.6566793500337 bayes_pls_golite062009
cation transmembrane transporter activity 2.61794461605199 bayes_pls_golite062009
calcium-release channel activity 2.58969194870156 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.47257819150887 bayes_pls_golite062009
phosphatase activity 2.4502869290841 bayes_pls_golite062009
phosphoric ester hydrolase activity 2.38923256228405 bayes_pls_golite062009
ubiquitin-protein ligase activity 2.35894350869919 bayes_pls_golite062009
isomerase activity 2.31710030777753 bayes_pls_golite062009
small conjugating protein ligase activity 2.12083180880718 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.07186557005331 bayes_pls_golite062009
transcription regulator activity 1.85589011277711 bayes_pls_golite062009
receptor activity 1.78361575899771 bayes_pls_golite062009
transmembrane receptor activity 1.7459556028988 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.68688812199737 bayes_pls_golite062009
kinase activity 1.67904764195462 bayes_pls_golite062009
binding 1.63170667962375 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.57898291235576 bayes_pls_golite062009
molecular transducer activity 1.53711974553033 bayes_pls_golite062009
signal transducer activity 1.53711974553033 bayes_pls_golite062009
phosphoprotein phosphatase activity 1.5101001424727 bayes_pls_golite062009
protein kinase activity 1.45320632553313 bayes_pls_golite062009
acid-amino acid ligase activity 1.4415534360016 bayes_pls_golite062009
drug binding 1.39643621593407 bayes_pls_golite062009
heat shock protein binding 1.35268080101836 bayes_pls_golite062009
transferase activity 1.34122735969662 bayes_pls_golite062009
receptor serine/threonine kinase binding 1.32709321745178 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 1.32470025150272 bayes_pls_golite062009
transforming growth factor beta receptor binding 1.32470025150272 bayes_pls_golite062009
DNA binding 1.31957293306432 bayes_pls_golite062009
steroid hormone receptor binding 1.26630556032955 bayes_pls_golite062009
transporter activity 1.25197125648774 bayes_pls_golite062009
protein binding 1.08765413491791 bayes_pls_golite062009
SMAD binding 1.04905381164355 bayes_pls_golite062009
transmembrane transporter activity 1.03909235910355 bayes_pls_golite062009
nucleic acid binding 1.01193875360949 bayes_pls_golite062009
catalytic activity 0.885282592863018 bayes_pls_golite062009
transcription activator activity 0.873307397500777 bayes_pls_golite062009
transcription repressor activity 0.841959344808827 bayes_pls_golite062009
substrate-specific transporter activity 0.789390402522536 bayes_pls_golite062009
hormone receptor binding 0.780875583795532 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 0.777060600234881 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.763739321802433 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.763739321802433 bayes_pls_golite062009
nuclear hormone receptor binding 0.761034574704448 bayes_pls_golite062009
intracellular ligand-gated ion channel activity 0.727019445105701 bayes_pls_golite062009
protein serine/threonine phosphatase activity 0.683689287992235 bayes_pls_golite062009
transcription factor activity 0.672036990681626 bayes_pls_golite062009
protein serine/threonine kinase activity 0.671059013500415 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 0.625352830428438 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.525950701946406 bayes_pls_golite062009
signal sequence binding 0.49295886046194 bayes_pls_golite062009
enzyme binding 0.44905827271946 bayes_pls_golite062009
superoxide-generating NADPH oxidase activity 0.37588912752498 bayes_pls_golite062009
unfolded protein binding 0.27473817613726 bayes_pls_golite062009
transcription factor binding 0.273314664611729 bayes_pls_golite062009
activin binding 0.262691232876501 bayes_pls_golite062009
histone binding 0.221748741603068 bayes_pls_golite062009
transcription elongation regulator activity 0.21145105012677 bayes_pls_golite062009
hydrolase activity 0.172906111259113 bayes_pls_golite062009
peroxisome targeting sequence binding 0.0468412220974996 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor 0.0437303095920707 bayes_pls_golite062009
transcription cofactor activity 0.0131115480611301 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle