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View Structure Prediction Details

Protein: STP22_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 385 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STP22_YEAST.

Description E-value Query
Range
Subject
Range
STP22 - Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into ...
gi|190406431 - gi|190406431|gb|EDV09698.1| hypothetical protein SCRG_05394 [Saccharomyces cerevisiae RM11-1a]
gi|207347351 - gi|207347351|gb|EDZ73550.1| YCL008Cp-like protein [Saccharomyces cerevisiae AWRI1631]
STP22_YEAST - Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease OS=Sac...
5.0E-97 [1..385] [1..385]
gi|45361377, gi|... - gi|89271346|emb|CAJ83421.1| tumor susceptibility gene 101 [Xenopus tropicalis], gi|45361377|ref|NP_9...
9.0E-79 [21..379] [11..384]
gi|46249848, gi|... - gi|46249848|gb|AAH68660.1| MGC81040 protein [Xenopus laevis], gi|147905306|ref|NP_001084620.1| hypot...
2.0E-77 [21..379] [11..383]
TS101_MOUSE - Tumor susceptibility gene 101 protein OS=Mus musculus GN=Tsg101 PE=1 SV=2
2.0E-77 [21..379] [11..380]
gi|114636476 - gi|114636476|ref|XP_001173373.1| PREDICTED: tumor susceptibility gene 101 isoform 1 [Pan troglodytes...
TSG101 - tumor susceptibility gene 101
gi|60813968, gi|... - gi|61355217|gb|AAX41115.1| tumor susceptibility gene 101 [synthetic construct], gi|60813968|gb|AAX36...
5.0E-77 [21..379] [11..379]
gi|9454364 - gi|9454364|gb|AAF87776.1| tumor susceptibility protein 101 [Chelonia mydas]
1.0E-76 [21..379] [11..381]
TSG101-PA - The gene tumor suppressor protein 101 is referred to in FlyBase by the symbol Dmel\TSG101 (CG9712, F...
2.0E-63 [22..379] [13..399]
tsg-101 - status:Partially_confirmed UniProt:O76258 protein_id:AAC25822.2
2.0E-63 [26..379] [16..416]
gi|44980427 - gi|44980427|gb|AAS50360.1| AAL006Cp [Ashbya gossypii ATCC 10895]
gi|45184818, gi|... - gi|45184818|ref|NP_982536.1| AAL006Cp [Ashbya gossypii ATCC 10895], gi|44980427|gb|AAS50360.1| AAL00...
2.0E-62 [3..380] [4..439]

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Predicted Domain #1
Region A:
Residues: [1-233]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSANGKISVP EAVVNWLFKV IQPIYNDGRT TFHDSLALLD NFHSLRPRTR VFTHSDGTPQ  60
   61 LLLSIYGTIS TGEDGSSPHS IPVIMWVPSM YPVKPPFISI NLENFDMNTI SSSLPIQEYI 120
  121 DSNGWIALPI LHCWDPAAMN LIMVVQELMS LLHEPPQDQA PSLPPKPNTQ LQQEQNTPPL 180
  181 PPKPKSPHLK PPLPPPPPPQ PASNALDLMD MDNTDISPTN HHEMLQNLQT VVN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.69897
Match: 1uzxA_
Description: A complex of the Vps23 UEV with ubiquitin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
small conjugating protein ligase activity 5.39546375801135 bayes_pls_golite062009
ubiquitin-protein ligase activity 5.24355531841986 bayes_pls_golite062009
acid-amino acid ligase activity 4.3569172339832 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 2.17039194032383 bayes_pls_golite062009
ligase activity 1.88059319399119 bayes_pls_golite062009
protein binding 1.12473783261956 bayes_pls_golite062009
catalytic activity 0.891402822028799 bayes_pls_golite062009
binding 0.7313332818323 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [234-385]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELYREDVDYV ADKILTRQTV MQESIARFHE IIAIDKNHLR AVEQAIEQTM HSLNAQIDVL  60
   61 TANRAKVQQF SSTSHVDDED VNSIAVAKTD GLNQLYNLVA QDYALTDTIE CLSRMLHRGT 120
  121 IPLDTFVKQG RELARQQFLV RWHIQRITSP LS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle