YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|220952868
Organism:	synthetic construct
Length:	108 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|220952868.

Description	E-value	Query Range	Subject Range
gi\|50728692 - gi\|50728692\|ref\|XP_416239.1\| PREDICTED: similar to RBX1 protein [Gallus gallus]	116.0	[0..1]	[108..256]
gi\|19067884, gi\|... - gi\|62869880\|gb\|AAY18085.1\| hyperosmotic protein 21 [Salmo salar], gi\|62869878\|gb\|AAY18084.1\| hyperos...	111.0	[0..1]	[108..86]
gi\|78394982 - gi\|78394982\|gb\|AAI07832.1\| Rbx1 protein [Danio rerio]	110.0	[0..1]	[108..19]
gi\|114686561 - gi\|114686561\|ref\|XP_001167997.1\| PREDICTED: similar to RBX1 protein isoform 3 [Pan troglodytes]	107.0	[0..1]	[108..5]
gi\|51980558 - gb\|AAH82183.1\| Unknown (protein for MGC:98645) [Xenopus laevis] gi\|90075658, gi\|... - gi\|90075658\|dbj\|BAE87509.1\| unnamed protein product [Macaca fascicularis], gi\|84579139\|dbj\|BAE73003.... gi\|118082672 - gi\|118082672\|ref\|XP_416239.2\| PREDICTED: similar to RBX1 protein [Gallus gallus] CCDS14009.1_1 - null gi\|114686557 - gi\|114686557\|ref\|XP_515153.2\| PREDICTED: similar to RBX1 protein isoform 5 [Pan troglodytes] RBX1 - ring-box 1 gi\|126338707 - gi\|126338707\|ref\|XP_001363807.1\| PREDICTED: similar to RBX1 protein [Monodelphis domestica] RBX1_MOUSE - E3 ubiquitin-protein ligase RBX1 OS=Mus musculus GN=Rbx1 PE=1 SV=1 gi\|76617022, gi\|... - gi\|88682859\|gb\|AAI05330.1\| Ring-box 1 [Bos taurus], gi\|76617022\|ref\|XP_597082.2\| PREDICTED: similar ... gi\|109451460, gi... - gi\|109452056\|emb\|CAK54890.1\| RBX1 [synthetic construct], gi\|109451460\|emb\|CAK54591.1\| RBX1 [syntheti... HGNC:9928\|MIM:60... - 1 gi\|72679391, gi\|... - gi\|77628004\|ref\|NP_001029307.1\| ring-box 1 [Rattus norvegicus], gi\|72679391\|gb\|AAI00259.1\| Ring-box ... tr\|M3X867\|M3X867... - Ring-box 1 OS=Felis catus GN=RBX1 PE=4 SV=1 gi\|197127417 - gi\|197127417\|gb\|ACH43915.1\| putative RBX1 protein [Taeniopygia guttata] gi\|149743062 - gi\|149743062\|ref\|XP_001502369.1\| PREDICTED: similar to RING-box protein 1 (Rbx1) (Regulator of culli...	107.0	[0..1]	[108..5]
gi\|57092733 - gi\|57092733\|ref\|XP_531722.1\| PREDICTED: similar to RING-box protein 1 (Rbx1) [Canis familiaris]	107.0	[0..1]	[105..105]

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Predicted Domain #1

Region A:
Residues: [1-108]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVDEDGYEV PSSSSKGDKK RFEVKKWNAV ALWAWDIVVD NCAICRNHIM DLCIECQANQ  60
   61 ASATSEECTV AWGVCNHAFH FHCISRWLKT RQVCPLDNRE WDFQKYGH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.09691
Match:	1u6gB
Description:	Crystal Structure of The Cand1-Cul1-Roc1 Complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	10.2497392096259	bayes_pls_golite062009
small conjugating protein ligase activity	10.0460587929138	bayes_pls_golite062009
acid-amino acid ligase activity	8.99384576623969	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	7.6988425139962	bayes_pls_golite062009
NEDD8 ligase activity	5.61847630780351	bayes_pls_golite062009
ligase activity	3.92677358871643	bayes_pls_golite062009
binding	2.78710909602478	bayes_pls_golite062009
protein binding	1.5975811408548	bayes_pls_golite062009
small conjugating protein-specific protease activity	1.2126425713931	bayes_pls_golite062009
ubiquitin-specific protease activity	1.03469202541773	bayes_pls_golite062009
transcription regulator activity	0.943706743211193	bayes_pls_golite062009
transcription factor binding	0.90065892745057	bayes_pls_golite062009
nucleic acid binding	0.708499177773075	bayes_pls_golite062009
hydrolase activity	0.52386813728704	bayes_pls_golite062009
cysteine-type peptidase activity	0.50197530717959	bayes_pls_golite062009
SUMO polymer binding	0.417597867824941	bayes_pls_golite062009
transcription repressor activity	0.393708074680332	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.392372133643049	bayes_pls_golite062009
DNA binding	0.365874679056682	bayes_pls_golite062009
ubiquitin thiolesterase activity	0.265769062717221	bayes_pls_golite062009
catalytic activity	0.14112008370434	bayes_pls_golite062009
enzyme binding	0.104373352314595	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: