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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Dun1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADH4
  • mitochondrion
  • fermentation
  • NADH oxidation
  • alcohol dehydrogenase activity, zinc-dependent
  • AGX1
  • mitochondrion
  • glycine biosynthetic process, by transamination of glyoxylate
  • alanine-glyoxylate transaminase activity
  • AHA1
  • cytoplasm
  • protein folding
  • response to stress
  • chaperone binding
  • chaperone activator activity
  • ATPase activator activity
  • CDC33
  • nucleus
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • translational initiation
  • translation initiation factor activity
  • CPR1
  • nucleus
  • mitochondrion
  • histone deacetylase complex
  • ascospore formation
  • protein metabolic process
  • peptidyl-prolyl cis-trans isomerase activity
  • DUN1
  • nucleus
  • DNA damage checkpoint
  • cell cycle checkpoint
  • telomere maintenance
  • protein amino acid phosphorylation
  • protein kinase activity
  • HOM2
  • nucleus
  • cytoplasm
  • response to drug
  • methionine metabolic process
  • threonine metabolic process
  • homoserine biosynthetic process
  • aspartate-semialdehyde dehydrogenase activity
  • PDX3
  • cellular_component
  • telomere maintenance
  • fatty acid metabolic process
  • pyridoxamine-phosphate oxidase activity
  • PGM2
  • cytosol
  • response to temperature stimulus
  • energy reserve metabolic process
  • UDP-glucose metabolic process
  • trehalose biosynthetic process
  • alcohol metabolic process
  • glucose metabolic process
  • cellular calcium ion homeostasis
  • vacuolar protein catabolic process
  • carbohydrate metabolic process
  • glycogen biosynthetic process
  • glucose 6-phosphate metabolic process
  • cellular carbohydrate metabolic process
  • galactose catabolic process
  • glucose 1-phosphate metabolic process
  • cellular cation homeostasis
  • phosphoglucomutase activity
  • SOD1
  • mitochondrial intermembrane space
  • mitochondrion
  • cytosol
  • age-dependent response to reactive oxygen species involved in chronological cell aging
  • response to cold
  • superoxide metabolic process
  • cellular copper ion homeostasis
  • response to drug
  • cellular zinc ion homeostasis
  • antioxidant activity
  • metal ion binding
  • oxidoreductase activity
  • superoxide dismutase activity
  • TMA29
  • nucleus
  • cytoplasm
  • ribosome
  • metabolic process
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
  • VMA4
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
  • vacuolar acidification
  • proton-transporting ATPase activity, rotational mechanism
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    eukaryotic translation initiation factor 4F complex 7.6087E-3 12 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    serine family amino acid biosynthetic process 2.1777E-4 12 12 2 6292
    homeostatic process 6.0531E-4 12 408 5 6292
    cellular cation homeostasis 8.9047E-4 12 105 3 6292
    cation homeostasis 9.9293E-4 12 109 3 6292
    serine family amino acid metabolic process 1.1399E-3 12 27 2 6292
    cellular ion homeostasis 1.2812E-3 12 119 3 6292
    cellular chemical homeostasis 1.2812E-3 12 119 3 6292
    cellular homeostasis 1.3126E-3 12 120 3 6292
    chemical homeostasis 1.4098E-3 12 123 3 6292
    ion homeostasis 1.4098E-3 12 123 3 6292
    response to temperature stimulus 1.5037E-3 12 31 2 6292
    glycine biosynthetic process, by transamination of glyoxylate 1.9072E-3 12 1 1 6292
    superoxide metabolic process 1.9072E-3 12 1 1 6292
    regulation of biological quality 2.3795E-3 12 551 5 6292
    metabolic process 3.2647E-3 12 3157 11 6292
    glucose 1-phosphate metabolic process 3.811E-3 12 2 1 6292
    age-dependent response to reactive oxygen species 3.811E-3 12 2 1 6292
    age-dependent response to reactive oxygen species involved in chronological cell aging 3.811E-3 12 2 1 6292
    glycine biosynthetic process 3.811E-3 12 2 1 6292
    glucose 6-phosphate metabolic process 3.811E-3 12 2 1 6292
    homoserine biosynthetic process 5.7116E-3 12 3 1 6292
    UDP-glucose metabolic process 5.7116E-3 12 3 1 6292
    cellular di-, tri-valent inorganic cation homeostasis 6.6839E-3 12 66 2 6292
    di-, tri-valent inorganic cation homeostasis 6.6839E-3 12 66 2 6292
    oxygen and reactive oxygen species metabolic process 7.6087E-3 12 4 1 6292
    galactose catabolic process 9.5026E-3 12 5 1 6292
    small molecule metabolic process 9.6932E-3 12 760 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    oxidoreductase activity 1.0483E-4 12 281 5 6292
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 5.6006E-4 12 19 2 6292
    catalytic activity 6.7428E-4 12 2150 10 6292
    oxidoreductase activity, acting on the aldehyde or oxo group of donors 9.7633E-4 12 25 2 6292
    pyridoxamine-phosphate oxidase activity 1.9072E-3 12 1 1 6292
    aspartate-semialdehyde dehydrogenase activity 1.9072E-3 12 1 1 6292
    alanine-glyoxylate transaminase activity 1.9072E-3 12 1 1 6292
    superoxide dismutase activity 3.811E-3 12 2 1 6292
    alcohol dehydrogenase activity, zinc-dependent 3.811E-3 12 2 1 6292
    phosphoglucomutase activity 3.811E-3 12 2 1 6292
    oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3.811E-3 12 2 1 6292
    oxidoreductase activity, acting on superoxide radicals as acceptor 3.811E-3 12 2 1 6292
    chaperone activator activity 5.7116E-3 12 3 1 6292
    isomerase activity 5.7327E-3 12 61 2 6292

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