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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Gcn5. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 9 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADA2
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
  • chromatin modification
  • histone acetylation
  • transcription coactivator activity
  • FET4
  • integral to plasma membrane
  • plasma membrane
  • low-affinity iron ion transport
  • intracellular copper ion transport
  • copper ion import
  • iron ion transmembrane transporter activity
  • copper ion transmembrane transporter activity
  • GCN5
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
  • chromatin modification
  • histone acetylation
  • histone acetyltransferase activity
  • transcription coactivator activity
  • HFI1
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
  • chromatin modification
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • histone acetylation
  • transcription cofactor activity
  • transcription coactivator activity
  • SGF29
  • SAGA complex
  • histone acetylation
  • molecular_function
  • SPT7
  • SLIK (SAGA-like) complex
  • mitochondrion
  • SAGA complex
  • chromatin modification
  • protein complex assembly
  • conjugation with cellular fusion
  • histone acetylation
  • structural molecule activity
  • TAF6
  • transcription factor TFIID complex
  • SLIK (SAGA-like) complex
  • SAGA complex
  • chromatin modification
  • protein amino acid acetylation
  • histone acetylation
  • chromatin organization
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • TRA1
  • NuA4 histone acetyltransferase complex
  • SLIK (SAGA-like) complex
  • SAGA complex
  • histone acetyltransferase complex
  • DNA repair
  • histone acetylation
  • regulation of transcription from RNA polymerase II promoter
  • histone acetyltransferase activity
  • UBP8
  • SAGA complex
  • protein deubiquitination
  • ubiquitin-specific protease activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    SAGA complex 4.7355E-20 9 22 8 6292
    SAGA-type complex 7.26E-20 9 23 8 6292
    histone acetyltransferase complex 2.6165E-17 9 44 8 6292
    SLIK (SAGA-like) complex 7.7922E-15 9 16 6 6292
    nucleoplasm part 4.1137E-11 9 245 8 6292
    nucleoplasm 7.5193E-11 9 264 8 6292
    nuclear lumen 5.7468E-9 9 453 8 6292
    Ada2/Gcn5/Ada3 transcription activator complex 2.0214E-8 9 5 3 6292
    organelle lumen 1.1527E-7 9 660 8 6292
    intracellular organelle lumen 1.1527E-7 9 660 8 6292
    membrane-enclosed lumen 1.8386E-7 9 700 8 6292
    nuclear part 6.6425E-6 9 1103 8 6292
    protein complex 8.4269E-6 9 1137 8 6292
    macromolecular complex 1.4222E-4 9 1635 8 6292
    nucleus 7.7873E-4 9 2041 8 6292
    organelle part 1.8134E-3 9 2282 8 6292
    intracellular organelle part 1.8134E-3 9 2282 8 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    histone acetylation 3.8611E-15 9 36 7 6292
    protein amino acid acetylation 2.4688E-14 9 46 7 6292
    protein amino acid acylation 1.5678E-13 9 59 7 6292
    covalent chromatin modification 2.8938E-12 9 88 7 6292
    histone modification 2.8938E-12 9 88 7 6292
    chromatin modification 2.9424E-10 9 168 7 6292
    post-translational protein modification 8.5295E-10 9 357 8 6292
    chromatin organization 1.1201E-9 9 203 7 6292
    protein modification process 1.2443E-8 9 499 8 6292
    macromolecule modification 3.5432E-8 9 569 8 6292
    chromosome organization 1.2328E-6 9 555 7 6292
    cellular protein metabolic process 5.3897E-6 9 1074 8 6292
    protein metabolic process 8.369E-6 9 1136 8 6292
    organelle organization 1.4948E-4 9 1127 7 6292
    cellular component organization 1.3818E-3 9 1582 7 6292
    low-affinity iron ion transport 1.4304E-3 9 1 1 6292
    cellular macromolecule metabolic process 1.8315E-3 9 2285 8 6292
    macromolecule metabolic process 2.2547E-3 9 2349 8 6292
    intracellular copper ion transport 7.1338E-3 9 5 1 6292
    iron ion transmembrane transport 7.1338E-3 9 5 1 6292
    copper ion transmembrane transport 8.5551E-3 9 6 1 6292
    copper ion import 8.5551E-3 9 6 1 6292
    transcription from RNA polymerase II promoter 9.881E-3 9 335 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    transcription coactivator activity 2.6578E-6 9 21 3 6292
    transcription cofactor activity 1.9476E-5 9 40 3 6292
    transcription factor binding 2.4275E-5 9 43 3 6292
    transcription activator activity 6.9885E-5 9 61 3 6292
    histone acetyltransferase activity 2.4464E-4 9 17 2 6292
    lysine N-acetyltransferase activity 2.4464E-4 9 17 2 6292
    transcription regulator activity 8.4037E-4 9 339 4 6292
    N-acetyltransferase activity 9.3856E-4 9 33 2 6292
    N-acyltransferase activity 1.245E-3 9 38 2 6292
    acetyltransferase activity 2.1502E-3 9 50 2 6292
    transferase activity, transferring acyl groups other than amino-acyl groups 7.1217E-3 9 92 2 6292
    acyltransferase activity 7.1217E-3 9 92 2 6292
    copper ion transmembrane transporter activity 7.1338E-3 9 5 1 6292
    transferase activity, transferring acyl groups 9.541E-3 9 107 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle