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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Ctk1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 9 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC37
  • cytoplasm
  • MAPKKK cascade involved in osmosensory signaling pathway
  • regulation of stress-activated MAPK cascade
  • spindle pole body duplication in nuclear envelope
  • unfolded protein binding
  • CTK1
  • nucleus
  • carboxy-terminal domain protein kinase complex
  • telomere maintenance
  • mRNA 3'-end processing
  • protein amino acid phosphorylation
  • positive regulation of RNA elongation
  • cyclin-dependent protein kinase activity
  • GBP2
  • nucleus
  • telomere maintenance
  • poly(A)+ mRNA export from nucleus
  • RNA binding
  • telomeric DNA binding
  • HHF1, HHF2
  • nucleus
  • nucleoplasm part
  • nuclear nucleosome
  • chromosome
  • replication fork protection complex
  • chromatin remodeling complex
  • nucleosome
  • histone acetyltransferase complex
  • nucleoplasm
  • histone H3-K79 methylation
  • DNA repair
  • negative regulation of transcription
  • chromatin assembly or disassembly
  • positive regulation of transcription
  • nucleosome assembly
  • DNA binding
  • HRB1
  • nucleus
  • cytoplasm
  • heterogeneous nuclear ribonucleoprotein complex
  • poly(A)+ mRNA export from nucleus
  • RNA binding
  • KRE33
  • nucleolus
  • ribosome biogenesis
  • molecular_function
  • NPL3
  • nucleus
  • cytoplasm
  • mRNA export from nucleus
  • pseudohyphal growth
  • poly(A) RNA binding
  • mRNA binding
  • SFP1
  • nucleus
  • cytoplasm
  • transcription from RNA polymerase III promoter
  • regulation of cell size
  • ribosome biogenesis
  • transcription factor activity
  • SIT4
  • nucleus
  • cytoplasm
  • DNA repair
  • G1/S transition of mitotic cell cycle
  • cellular cell wall organization
  • telomere maintenance
  • intracellular protein kinase cascade
  • protein amino acid phosphorylation
  • replicative cell aging
  • actin cytoskeleton organization
  • protein serine/threonine phosphatase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleus 7.7873E-4 9 2041 8 6292
    replication fork protection complex 2.859E-3 9 2 1 6292
    carboxy-terminal domain protein kinase complex 4.2857E-3 9 3 1 6292
    heterogeneous nuclear ribonucleoprotein complex 4.2857E-3 9 3 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    poly(A)+ mRNA export from nucleus 3.8057E-5 9 7 2 6292
    mRNA export from nucleus 9.6826E-5 9 68 3 6292
    mRNA transport 9.6826E-5 9 68 3 6292
    RNA export from nucleus 1.5737E-4 9 80 3 6292
    RNA transport 1.6331E-4 9 81 3 6292
    nucleic acid transport 1.6331E-4 9 81 3 6292
    establishment of RNA localization 1.6331E-4 9 81 3 6292
    RNA localization 2.3847E-4 9 92 3 6292
    biological regulation 2.4341E-4 9 1213 7 6292
    nucleobase, nucleoside, nucleotide and nucleic acid transport 2.7054E-4 9 96 3 6292
    nuclear export 3.3317E-4 9 103 3 6292
    regulation of biological quality 4.7304E-4 9 551 5 6292
    intracellular protein kinase cascade 4.939E-4 9 24 2 6292
    signal transmission via phosphorylation event 4.939E-4 9 24 2 6292
    nuclear transport 6.6098E-4 9 130 3 6292
    nucleocytoplasmic transport 6.6098E-4 9 130 3 6292
    stress-activated MAPK cascade 1.4304E-3 9 1 1 6292
    histone H3-K79 methylation 1.4304E-3 9 1 1 6292
    regulation of MAPKKK cascade 1.4304E-3 9 1 1 6292
    regulation of intracellular protein kinase cascade 1.4304E-3 9 1 1 6292
    regulation of stress-activated MAPK cascade 1.4304E-3 9 1 1 6292
    regulation of stress-activated protein kinase signaling pathway 1.4304E-3 9 1 1 6292
    stress-activated protein kinase signaling pathway 1.4304E-3 9 1 1 6292
    histone lysine methylation 2.859E-3 9 2 1 6292
    regulation of cellular response to stress 2.859E-3 9 2 1 6292
    regulation of RNA elongation 4.2857E-3 9 3 1 6292
    positive regulation of RNA elongation 4.2857E-3 9 3 1 6292
    regulation of response to stress 4.2857E-3 9 3 1 6292
    chromosome organization 5.2635E-3 9 555 4 6292
    anatomical structure homeostasis 6.3635E-3 9 286 3 6292
    telomere organization 6.3635E-3 9 286 3 6292
    telomere maintenance 6.3635E-3 9 286 3 6292
    DNA metabolic process 6.3704E-3 9 585 4 6292
    cellular response to stress 6.6158E-3 9 290 3 6292
    protein amino acid phosphorylation 8.8641E-3 9 103 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleic acid binding 1.1464E-3 9 666 5 6292
    binding 3.5377E-3 9 1294 6 6292
    DNA binding 4.6591E-3 9 256 3 6292
    poly(A) RNA binding 7.1338E-3 9 5 1 6292
    single-stranded RNA binding 7.1338E-3 9 5 1 6292
    poly-purine tract binding 7.1338E-3 9 5 1 6292

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