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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Rad53. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 11 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ASF1
  • chromatin assembly complex
  • histone acetylation
  • DNA replication-independent nucleosome assembly
  • chromatin silencing at silent mating-type cassette
  • nucleosome disassembly
  • chromatin silencing at telomere
  • DNA replication-dependent nucleosome assembly
  • histone binding
  • CDC13
  • nuclear telomere cap complex
  • telomere maintenance
  • telomere capping
  • telomeric DNA binding
  • EDE1
  • cellular bud tip
  • cellular bud neck
  • actin cortical patch
  • endocytosis
  • ubiquitin binding
  • KAP95
  • cytoplasm
  • nuclear pore
  • protein import into nucleus
  • nuclear pore complex assembly
  • protein transmembrane transporter activity
  • PTC2
  • nucleus
  • cytoplasm
  • DNA damage checkpoint
  • inactivation of MAPK activity involved in osmosensory signaling pathway
  • G1/S transition of mitotic cell cycle
  • protein amino acid dephosphorylation
  • response to unfolded protein
  • regulation of cyclin-dependent protein kinase activity
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • catalytic activity
  • metal ion binding
  • hydrolase activity
  • RAD53
  • nucleus
  • DNA replication initiation
  • DNA repair
  • deoxyribonucleoside triphosphate biosynthetic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • DNA replication origin binding
  • protein serine/threonine/tyrosine kinase activity
  • SRP1
  • nucleus
  • cytoplasm
  • nucleocytoplasmic transport
  • protein transmembrane transporter activity
  • SWI4
  • nucleus
  • transcription
  • G1/S transition of mitotic cell cycle
  • DNA binding
  • transcription factor activity
  • TBF1
  • nucleus
  • nuclear chromosome
  • nuclear chromosome, telomeric region
  • loss of chromatin silencing
  • DNA binding
  • transcription factor activity
  • chromatin insulator sequence binding
  • UTP22
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • YTA7
  • nucleus
  • protein catabolic process
  • telomere maintenance
  • ATPase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleus 9.8699E-5 11 2041 10 6292
    nuclear chromosome, telomeric region 6.8913E-4 11 23 2 6292
    chromosome, telomeric region 9.5242E-4 11 27 2 6292
    intracellular organelle 8.2563E-3 11 4070 11 6292
    organelle 8.2787E-3 11 4071 11 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DNA replication-dependent nucleosome organization 1.7483E-3 11 1 1 6292
    pore complex assembly 1.7483E-3 11 1 1 6292
    nuclear pore complex assembly 1.7483E-3 11 1 1 6292
    chromatin disassembly 1.7483E-3 11 1 1 6292
    nucleosome disassembly 1.7483E-3 11 1 1 6292
    DNA replication-dependent nucleosome assembly 1.7483E-3 11 1 1 6292
    protein-DNA complex disassembly 1.7483E-3 11 1 1 6292
    G1/S transition of mitotic cell cycle 3.2518E-3 11 50 2 6292
    deoxyribonucleoside triphosphate biosynthetic process 3.4937E-3 11 2 1 6292
    nucleic acid metabolic process 3.9875E-3 11 1415 7 6292
    deoxyribonucleoside triphosphate metabolic process 6.9763E-3 11 4 1 6292
    deoxyribonucleotide biosynthetic process 6.9763E-3 11 4 1 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 7.316E-3 11 1566 7 6292
    inactivation of MAPK activity 8.7135E-3 11 5 1 6292
    inactivation of MAPK activity involved in osmosensory signaling pathway 8.7135E-3 11 5 1 6292
    negative regulation of MAP kinase activity 8.7135E-3 11 5 1 6292
    telomere capping 8.7135E-3 11 5 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    binding 1.1791E-6 11 1294 10 6292
    protein transmembrane transporter activity 9.9377E-5 11 9 2 6292
    macromolecule transmembrane transporter activity 9.9377E-5 11 9 2 6292
    DNA binding 7.0441E-4 11 256 4 6292
    chromatin insulator sequence binding 1.7483E-3 11 1 1 6292
    sequence-specific DNA binding 3.2518E-3 11 50 2 6292
    nucleic acid binding 3.5073E-3 11 666 5 6292
    protein transporter activity 4.3546E-3 11 58 2 6292
    transcription factor activity 5.1204E-3 11 63 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle