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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Cdc7. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 18 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BFR2
  • nucleolus
  • ER to Golgi vesicle-mediated transport
  • molecular_function
  • BIR1
  • spindle midzone
  • mitochondrion
  • spindle
  • condensed nuclear chromosome kinetochore
  • mitotic spindle elongation
  • chromosome segregation
  • molecular_function
  • BNA5
  • nucleus
  • cytoplasm
  • NAD biosynthetic process
  • kynureninase activity
  • CDC7
  • nucleus
  • Dbf4-dependent protein kinase complex
  • DNA replication initiation
  • protein amino acid phosphorylation
  • protein serine/threonine kinase activity
  • ECM10
  • mitochondrion
  • mitochondrial nucleoid
  • protein targeting to mitochondrion
  • protein refolding
  • molecular_function
  • JIP3
    NUT1
  • nucleus
  • mitochondrion
  • regulation of transcription from RNA polymerase II promoter
  • molecular_function
  • PDC5
  • nucleus
  • cytoplasm
  • cytosol
  • pyruvate metabolic process
  • glucose catabolic process to ethanol
  • pyruvate decarboxylase activity
  • PDC6
  • cytoplasm
  • ethanol metabolic process
  • pyruvate decarboxylase activity
  • PST2
  • cytoplasm
  • mitochondrion
  • biological_process
  • molecular_function
  • RPC19
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • SAR1
  • COPII vesicle coat
  • ER to Golgi vesicle-mediated transport
  • GTPase activity
  • SEC27
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • STI1
  • cytoplasm
  • protein folding
  • chaperone inhibitor activity
  • chaperone activator activity
  • Hsp90 protein binding
  • Hsp70 protein binding
  • THI3
  • nucleus
  • cytosol
  • positive regulation of transcription from RNA polymerase II promoter
  • thiamin biosynthetic process
  • transcription activator activity
  • carboxy-lyase activity
  • TPS1
  • cytoplasm
  • alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
  • carbohydrate metabolic process
  • response to drug
  • trehalose biosynthetic process
  • response to stress
  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
  • UBI4
  • cytoplasm
  • protein deubiquitination
  • ascospore formation
  • protein polyubiquitination
  • protein monoubiquitination
  • response to stress
  • protein ubiquitination
  • protein tag
  • ATP-dependent protein binding
  • VAC14
  • fungal-type vacuole membrane
  • vacuole
  • vacuole inheritance
  • phospholipid metabolic process
  • enzyme activator activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    vesicle coat 4.1079E-3 18 34 2 6292
    coated vesicle membrane 4.3495E-3 18 35 2 6292
    cytoplasmic vesicle membrane 4.3495E-3 18 35 2 6292
    vesicle membrane 4.3495E-3 18 35 2 6292
    membrane coat 5.113E-3 18 38 2 6292
    coated membrane 5.113E-3 18 38 2 6292
    cytoplasmic vesicle part 5.3803E-3 18 39 2 6292
    Dbf4-dependent protein kinase complex 5.7138E-3 18 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    monohydric alcohol metabolic process 4.1874E-4 18 11 2 6292
    ethanol metabolic process 4.1874E-4 18 11 2 6292
    ER to Golgi vesicle-mediated transport 1.5656E-3 18 83 3 6292
    vitamin biosynthetic process 8.0666E-3 18 48 2 6292
    water-soluble vitamin biosynthetic process 8.0666E-3 18 48 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    carboxy-lyase activity 2.1745E-5 18 20 3 6292
    pyruvate decarboxylase activity 4.6226E-5 18 4 2 6292
    carbon-carbon lyase activity 7.607E-5 18 30 3 6292
    lyase activity 1.8532E-3 18 88 3 6292
    chaperone inhibitor activity 2.8608E-3 18 1 1 6292
    hydrolase activity, acting on acid carbon-carbon bonds 2.8608E-3 18 1 1 6292
    hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances 2.8608E-3 18 1 1 6292
    ATP-dependent protein binding 2.8608E-3 18 1 1 6292
    kynureninase activity 2.8608E-3 18 1 1 6292
    Hsp70 protein binding 5.7138E-3 18 2 1 6292
    Hsp90 protein binding 5.7138E-3 18 2 1 6292
    alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity 8.5592E-3 18 3 1 6292
    chaperone activator activity 8.5592E-3 18 3 1 6292
    heat shock protein binding 8.5592E-3 18 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle