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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Yku80. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 15 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
APT1
  • nucleus
  • cytoplasm
  • AMP biosynthetic process
  • adenine salvage
  • adenine phosphoribosyltransferase activity
  • ARO1
  • cytoplasm
  • aromatic amino acid family biosynthetic process
  • shikimate kinase activity
  • 3-dehydroquinate dehydratase activity
  • 3-phosphoshikimate 1-carboxyvinyltransferase activity
  • 3-dehydroquinate synthase activity
  • shikimate 5-dehydrogenase activity
  • DSS1
  • mitochondrial matrix
  • mitochondrion
  • RNA catabolic process
  • exoribonuclease II activity
  • ECM10
  • mitochondrion
  • mitochondrial nucleoid
  • protein targeting to mitochondrion
  • protein refolding
  • molecular_function
  • MTC5
  • fungal-type vacuole membrane
  • biological_process
  • molecular_function
  • OYE2
  • nucleus
  • cytoplasm
  • mitochondrion
  • biological_process
  • NADPH dehydrogenase activity
  • PRE1
  • nucleus
  • proteasome core complex, beta-subunit complex
  • ascospore formation
  • response to stress
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • PST2
  • cytoplasm
  • mitochondrion
  • biological_process
  • molecular_function
  • PUP3
  • proteasome core complex, beta-subunit complex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • SOD2
  • mitochondrial matrix
  • mitochondrion
  • age-dependent response to reactive oxygen species involved in chronological cell aging
  • oxygen and reactive oxygen species metabolic process
  • replicative cell aging
  • age-dependent response to oxidative stress involved in chronological cell aging
  • metal ion binding
  • oxidoreductase activity
  • superoxide dismutase activity
  • TMA29
  • nucleus
  • cytoplasm
  • ribosome
  • metabolic process
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
  • TPS1
  • cytoplasm
  • alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
  • carbohydrate metabolic process
  • response to drug
  • trehalose biosynthetic process
  • response to stress
  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
  • TSA2
  • cytoplasm
  • response to oxidative stress
  • thioredoxin peroxidase activity
  • peroxiredoxin activity
  • YHR033W
  • cytoplasm
  • biological_process
  • molecular_function
  • YKU80
  • nuclear chromatin
  • nuclear telomeric heterochromatin
  • double-strand break repair via homologous recombination
  • telomere maintenance
  • chromatin assembly or disassembly
  • chromatin silencing
  • double-strand break repair via nonhomologous end joining
  • donor selection
  • DNA binding
  • RNA binding
  • damaged DNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome core complex, beta-subunit complex 1.1065E-4 15 7 2 6292
    proteasome core complex 6.2447E-4 15 16 2 6292
    proteasome complex 5.6171E-3 15 48 2 6292
    mitochondrial matrix 7.64E-3 15 176 3 6292
    mitochondrial lumen 7.64E-3 15 176 3 6292
    alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) 9.5041E-3 15 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    AMP biosynthetic process 2.384E-3 15 1 1 6292
    adenine salvage 2.384E-3 15 1 1 6292
    purine base salvage 2.384E-3 15 1 1 6292
    response to stress 4.646E-3 15 497 5 6292
    adenine biosynthetic process 4.7627E-3 15 2 1 6292
    age-dependent response to reactive oxygen species 4.7627E-3 15 2 1 6292
    age-dependent response to reactive oxygen species involved in chronological cell aging 4.7627E-3 15 2 1 6292
    adenine metabolic process 7.136E-3 15 3 1 6292
    AMP metabolic process 9.5041E-3 15 4 1 6292
    donor selection 9.5041E-3 15 4 1 6292
    oxygen and reactive oxygen species metabolic process 9.5041E-3 15 4 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    oxidoreductase activity 3.5576E-4 15 281 5 6292
    antioxidant activity 1.5419E-3 15 25 2 6292
    exoribonuclease II activity 2.384E-3 15 1 1 6292
    3-dehydroquinate dehydratase activity 2.384E-3 15 1 1 6292
    3-dehydroquinate synthase activity 2.384E-3 15 1 1 6292
    shikimate 5-dehydrogenase activity 2.384E-3 15 1 1 6292
    3-phosphoshikimate 1-carboxyvinyltransferase activity 2.384E-3 15 1 1 6292
    shikimate kinase activity 2.384E-3 15 1 1 6292
    superoxide dismutase activity 4.7627E-3 15 2 1 6292
    oxidoreductase activity, acting on superoxide radicals as acceptor 4.7627E-3 15 2 1 6292
    adenine phosphoribosyltransferase activity 4.7627E-3 15 2 1 6292
    NADPH dehydrogenase activity 4.7627E-3 15 2 1 6292
    endopeptidase activity 7.0673E-3 15 54 2 6292
    carbon-oxygen lyase activity, acting on phosphates 7.136E-3 15 3 1 6292
    alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity 7.136E-3 15 3 1 6292

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