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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Ynl311c. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 10 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
DMA1
  • cytoplasm
  • mitotic cell cycle spindle assembly checkpoint
  • establishment of mitotic spindle orientation
  • septin ring assembly
  • molecular_function
  • DMA2
  • cytoplasm
  • mitotic cell cycle spindle assembly checkpoint
  • establishment of mitotic spindle orientation
  • septin ring assembly
  • molecular_function
  • ERG1
  • lipid particle
  • endoplasmic reticulum
  • ergosterol biosynthetic process
  • squalene monooxygenase activity
  • drug binding
  • RPT2
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT4
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RVB1
  • nucleus
  • Swr1 complex
  • Ino80 complex
  • chromatin remodeling complex
  • chromatin remodeling
  • regulation of transcription from RNA polymerase II promoter
  • ATPase activity
  • ATP-dependent 5'-3' DNA helicase activity
  • SKP1
  • RAVE complex
  • nucleus
  • cytoplasm
  • CBF3 complex
  • SCF ubiquitin ligase complex
  • kinetochore
  • G2/M transition of mitotic cell cycle
  • protein complex assembly
  • regulation of exit from mitosis
  • G1/S transition of mitotic cell cycle
  • cytokinesis
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • regulation of protein complex assembly
  • protein neddylation
  • kinetochore assembly
  • vacuolar acidification
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • DNA replication origin binding
  • ubiquitin-protein ligase activity
  • protein binding
  • STI1
  • cytoplasm
  • protein folding
  • chaperone inhibitor activity
  • chaperone activator activity
  • Hsp90 protein binding
  • Hsp70 protein binding
  • UBI4
  • cytoplasm
  • protein deubiquitination
  • ascospore formation
  • protein polyubiquitination
  • protein monoubiquitination
  • response to stress
  • protein ubiquitination
  • protein tag
  • ATP-dependent protein binding
  • YNL311C
  • ubiquitin ligase complex
  • ribosome
  • ubiquitin-dependent protein catabolic process
  • protein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome regulatory particle, base subcomplex 8.1369E-5 10 9 2 6292
    proteasome accessory complex 5.6509E-4 10 23 2 6292
    proteasome regulatory particle 5.6509E-4 10 23 2 6292
    ubiquitin ligase complex 1.983E-3 10 43 2 6292
    proteasome complex 2.4666E-3 10 48 2 6292
    RAVE complex 4.7611E-3 10 3 1 6292
    CBF3 complex 6.3436E-3 10 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    septin ring organization 4.7546E-5 10 7 2 6292
    septin cytoskeleton organization 4.7546E-5 10 7 2 6292
    septin ring assembly 4.7546E-5 10 7 2 6292
    modification-dependent protein catabolic process 6.7975E-5 10 156 4 6292
    ubiquitin-dependent protein catabolic process 6.7975E-5 10 156 4 6292
    cellular protein complex assembly 6.8733E-5 10 54 3 6292
    proteolysis involved in cellular protein catabolic process 7.324E-5 10 159 4 6292
    modification-dependent macromolecule catabolic process 8.2672E-5 10 164 4 6292
    cellular protein catabolic process 9.7335E-5 10 171 4 6292
    spindle localization 1.0162E-4 10 10 2 6292
    establishment of spindle localization 1.0162E-4 10 10 2 6292
    establishment of spindle orientation 1.0162E-4 10 10 2 6292
    establishment of mitotic spindle localization 1.0162E-4 10 10 2 6292
    establishment of mitotic spindle orientation 1.0162E-4 10 10 2 6292
    proteolysis 1.4079E-4 10 188 4 6292
    protein catabolic process 1.4372E-4 10 189 4 6292
    regulation of mitotic cell cycle 1.5614E-4 10 71 3 6292
    regulation of cellular component organization 1.8385E-4 10 75 3 6292
    regulation of cell cycle process 2.3113E-4 10 81 3 6292
    negative regulation of nuclear division 4.6984E-4 10 21 2 6292
    negative regulation of mitotic metaphase/anaphase transition 4.6984E-4 10 21 2 6292
    mitotic cell cycle spindle assembly checkpoint 4.6984E-4 10 21 2 6292
    negative regulation of mitosis 4.6984E-4 10 21 2 6292
    spindle assembly checkpoint 4.6984E-4 10 21 2 6292
    negative regulation of cell cycle 5.1639E-4 10 22 2 6292
    cellular macromolecule catabolic process 5.283E-4 10 265 4 6292
    spindle checkpoint 6.6893E-4 10 25 2 6292
    regulation of mitotic metaphase/anaphase transition 6.6893E-4 10 25 2 6292
    mitotic cell cycle spindle checkpoint 6.6893E-4 10 25 2 6292
    macromolecule catabolic process 7.8411E-4 10 294 4 6292
    mitotic cell cycle checkpoint 8.4071E-4 10 28 2 6292
    M phase of mitotic cell cycle 8.8893E-4 10 128 3 6292
    regulation of nuclear division 9.0222E-4 10 29 2 6292
    negative regulation of organelle organization 9.0222E-4 10 29 2 6292
    negative regulation of cellular component organization 9.0222E-4 10 29 2 6292
    regulation of mitosis 9.0222E-4 10 29 2 6292
    regulation of cell cycle 9.5103E-4 10 131 3 6292
    negative regulation of cell cycle process 1.0994E-3 10 32 2 6292
    mitotic metaphase/anaphase transition 1.47E-3 10 37 2 6292
    protein complex biogenesis 1.5493E-3 10 155 3 6292
    protein complex assembly 1.5493E-3 10 155 3 6292
    cellular macromolecular complex assembly 2.4587E-3 10 182 3 6292
    cellular protein metabolic process 2.7454E-3 10 1074 6 6292
    cellular catabolic process 2.8459E-3 10 415 4 6292
    regulation of organelle organization 2.8897E-3 10 52 2 6292
    establishment of organelle localization 3.228E-3 10 55 2 6292
    cell cycle checkpoint 3.584E-3 10 58 2 6292
    protein metabolic process 3.6994E-3 10 1136 6 6292
    protein ubiquitination 4.4831E-3 10 65 2 6292
    centromere complex assembly 4.7611E-3 10 3 1 6292
    kinetochore assembly 4.7611E-3 10 3 1 6292
    kinetochore organization 4.7611E-3 10 3 1 6292
    catabolic process 5.4561E-3 10 496 4 6292
    mitotic cell cycle 6.3872E-3 10 255 3 6292
    anatomical structure morphogenesis 6.5282E-3 10 257 3 6292
    cellular macromolecular complex subunit organization 6.671E-3 10 259 3 6292
    anatomical structure development 6.7431E-3 10 260 3 6292
    establishment of cell polarity 7.3933E-3 10 84 2 6292
    organelle localization 7.565E-3 10 85 2 6292
    establishment or maintenance of cell polarity 7.565E-3 10 85 2 6292
    protein modification by small protein conjugation 7.7386E-3 10 86 2 6292
    cellular developmental process 7.9625E-3 10 276 3 6292
    macromolecular complex assembly 8.3691E-3 10 281 3 6292
    M phase 9.4842E-3 10 294 3 6292
    microtubule cytoskeleton organization 9.7663E-3 10 97 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    chaperone inhibitor activity 1.5893E-3 10 1 1 6292
    drug binding 1.5893E-3 10 1 1 6292
    ATP-dependent protein binding 1.5893E-3 10 1 1 6292
    squalene monooxygenase activity 1.5893E-3 10 1 1 6292
    endopeptidase activity 3.1132E-3 10 54 2 6292
    Hsp70 protein binding 3.1764E-3 10 2 1 6292
    Hsp90 protein binding 3.1764E-3 10 2 1 6292
    ATPase activity 3.747E-3 10 211 3 6292
    chaperone activator activity 4.7611E-3 10 3 1 6292
    heat shock protein binding 4.7611E-3 10 3 1 6292
    peptidase activity, acting on L-amino acid peptides 9.3816E-3 10 95 2 6292

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