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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Cks1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 10 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BUR2
  • nucleus
  • transcription
  • mitotic sister chromatid segregation
  • response to DNA damage stimulus
  • cyclin-dependent protein kinase regulator activity
  • CDC28
  • nucleus
  • cytoplasm
  • ribosome
  • G2/M transition of mitotic cell cycle
  • transcription
  • S phase of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • regulation of meiosis
  • protein amino acid phosphorylation
  • cyclin-dependent protein kinase activity
  • CKS1
  • nucleus
  • cytoplasm
  • transcription
  • ubiquitin binding
  • protein kinase activator activity
  • CLB2
  • nucleus
  • cytoplasm
  • cellular bud neck
  • spindle pole body
  • spindle
  • G2/M transition of mitotic cell cycle
  • regulation of cyclin-dependent protein kinase activity
  • cyclin-dependent protein kinase regulator activity
  • CLB3
  • nucleus
  • cytoplasm
  • G2/M transition of mitotic cell cycle
  • S phase of mitotic cell cycle
  • regulation of cyclin-dependent protein kinase activity
  • cyclin-dependent protein kinase regulator activity
  • CLB5
  • nucleus
  • spindle assembly
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • positive regulation of DNA replication
  • regulation of S phase of mitotic cell cycle
  • premeiotic DNA synthesis
  • regulation of cyclin-dependent protein kinase activity
  • cyclin-dependent protein kinase regulator activity
  • CLN1
  • nucleus
  • cytoplasm
  • regulation of cyclin-dependent protein kinase activity
  • cyclin-dependent protein kinase regulator activity
  • HYP2
  • cytoplasm
  • mitochondrion
  • ribosome
  • translational initiation
  • translation initiation factor activity
  • protein binding
  • YDR170W-A
  • retrotransposon nucleocapsid
  • transposition, RNA-mediated
  • RNA binding
  • protein binding
  • YER138C
  • retrotransposon nucleocapsid
  • transposition, RNA-mediated
  • DNA-directed DNA polymerase activity
  • RNA-directed DNA polymerase activity
  • RNA binding
  • protein binding
  • ribonuclease activity
  • peptidase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleus 2.7855E-4 10 2041 9 6292
    membrane-bounded organelle 5.9511E-3 10 3771 10 6292
    intracellular membrane-bounded organelle 5.9511E-3 10 3771 10 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    regulation of cyclin-dependent protein kinase activity 3.1975E-9 10 14 4 6292
    regulation of kinase activity 4.7318E-8 10 26 4 6292
    regulation of protein kinase activity 4.7318E-8 10 26 4 6292
    regulation of transferase activity 4.7318E-8 10 26 4 6292
    G2/M transition of mitotic cell cycle 7.5002E-8 10 29 4 6292
    regulation of phosphorylation 9.9209E-8 10 31 4 6292
    regulation of phosphate metabolic process 2.3149E-7 10 38 4 6292
    regulation of phosphorus metabolic process 2.3149E-7 10 38 4 6292
    S phase 3.45E-7 10 10 3 6292
    S phase of mitotic cell cycle 3.45E-7 10 10 3 6292
    regulation of catalytic activity 4.2378E-7 10 44 4 6292
    regulation of molecular function 4.2378E-7 10 44 4 6292
    regulation of cell cycle 8.4027E-7 10 131 5 6292
    phosphorylation 3.9567E-6 10 179 5 6292
    interphase of mitotic cell cycle 1.0385E-5 10 97 4 6292
    interphase 1.0385E-5 10 97 4 6292
    phosphorus metabolic process 1.327E-5 10 229 5 6292
    phosphate metabolic process 1.327E-5 10 229 5 6292
    mitotic cell cycle 2.2422E-5 10 255 5 6292
    cell cycle 5.15E-5 10 525 6 6292
    cell cycle phase 1.4565E-4 10 376 5 6292
    cell cycle process 5.0875E-4 10 490 5 6292
    spindle assembly 1.5893E-3 10 1 1 6292
    G1/S transition of mitotic cell cycle 2.6741E-3 10 50 2 6292
    positive regulation of DNA replication 3.1764E-3 10 2 1 6292
    regulation of cellular process 4.6602E-3 10 796 5 6292
    regulation of S phase 4.7611E-3 10 3 1 6292
    regulation of S phase of mitotic cell cycle 4.7611E-3 10 3 1 6292
    positive regulation of DNA metabolic process 4.7611E-3 10 3 1 6292
    regulation of biological process 5.4298E-3 10 824 5 6292
    regulation of cell cycle process 6.8891E-3 10 81 2 6292
    regulation of cellular metabolic process 7.2118E-3 10 536 4 6292
    regulation of metabolic process 7.755E-3 10 547 4 6292
    premeiotic DNA synthesis 7.9239E-3 10 5 1 6292
    M phase 9.4842E-3 10 294 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein kinase regulator activity 2.2384E-11 10 46 6 6292
    kinase regulator activity 3.3363E-11 10 49 6 6292
    cyclin-dependent protein kinase regulator activity 1.9924E-10 10 26 5 6292
    enzyme regulator activity 2.22E-7 10 207 6 6292

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    Created and Maintained by: Michael Riffle