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Complex Overview

From Publication: Gavin A.C. et al. (2006) Proteome survey reveals modularity of the yeast cell machinery. Nature. 2006 Mar 30;440(7084):631-6. Epub 2006 Jan 22.
Notes: From the published set of protein complexes (core proteins only)
Complex Size: 9 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADA2
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
  • chromatin modification
  • histone acetylation
  • transcription coactivator activity
  • HFI1
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
  • chromatin modification
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • histone acetylation
  • transcription cofactor activity
  • transcription coactivator activity
  • NGG1
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
  • chromatin modification
  • response to drug
  • histone acetylation
  • transcription cofactor activity
  • SGF29
  • SAGA complex
  • histone acetylation
  • molecular_function
  • SGF73
  • SLIK (SAGA-like) complex
  • SAGA complex
  • chromatin modification
  • histone acetylation
  • histone acetyltransferase activity
  • structural molecule activity
  • SPT20
  • SLIK (SAGA-like) complex
  • SAGA complex
  • chromatin modification
  • histone acetylation
  • transcription cofactor activity
  • SPT3
  • SLIK (SAGA-like) complex
  • SAGA complex
  • chromatin modification
  • ascospore formation
  • conjugation with cellular fusion
  • pseudohyphal growth
  • histone acetylation
  • invasive growth in response to glucose limitation
  • transcription cofactor activity
  • SPT7
  • SLIK (SAGA-like) complex
  • mitochondrion
  • SAGA complex
  • chromatin modification
  • protein complex assembly
  • conjugation with cellular fusion
  • histone acetylation
  • structural molecule activity
  • SPT8
  • nucleus
  • SAGA complex
  • negative regulation of transcription from RNA polymerase II promoter
  • positive regulation of transcription from RNA polymerase II promoter
  • transcription cofactor activity
  • TATA-binding protein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    SAGA complex 1.1746E-23 9 22 9 6292
    SAGA-type complex 1.9296E-23 9 23 9 6292
    histone acetyltransferase complex 1.674E-20 9 44 9 6292
    SLIK (SAGA-like) complex 5.3211E-18 9 16 7 6292
    nucleoplasm part 1.7837E-13 9 245 9 6292
    nucleoplasm 3.5315E-13 9 264 9 6292
    nuclear lumen 4.8255E-11 9 453 9 6292
    organelle lumen 1.4638E-9 9 660 9 6292
    intracellular organelle lumen 1.4638E-9 9 660 9 6292
    membrane-enclosed lumen 2.4937E-9 9 700 9 6292
    Ada2/Gcn5/Ada3 transcription activator complex 2.0214E-8 9 5 3 6292
    nuclear part 1.5218E-7 9 1103 9 6292
    protein complex 2.0019E-7 9 1137 9 6292
    macromolecular complex 5.3146E-6 9 1635 9 6292
    nucleus 3.9292E-5 9 2041 9 6292
    organelle part 1.0749E-4 9 2282 9 6292
    intracellular organelle part 1.0749E-4 9 2282 9 6292
    membrane-bounded organelle 9.9391E-3 9 3771 9 6292
    intracellular membrane-bounded organelle 9.9391E-3 9 3771 9 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    histone acetylation 4.4724E-18 9 36 8 6292
    protein amino acid acetylation 3.851E-17 9 46 8 6292
    protein amino acid acylation 3.2666E-16 9 59 8 6292
    covalent chromatin modification 9.4297E-15 9 88 8 6292
    histone modification 9.4297E-15 9 88 8 6292
    chromatin modification 1.9271E-12 9 168 8 6292
    chromatin organization 8.975E-12 9 203 8 6292
    post-translational protein modification 8.5295E-10 9 357 8 6292
    protein modification process 1.2443E-8 9 499 8 6292
    chromosome organization 2.9055E-8 9 555 8 6292
    macromolecule modification 3.5432E-8 9 569 8 6292
    cellular protein metabolic process 5.3897E-6 9 1074 8 6292
    organelle organization 7.8634E-6 9 1127 8 6292
    protein metabolic process 8.369E-6 9 1136 8 6292
    cellular macromolecule metabolic process 1.0877E-4 9 2285 9 6292
    cellular component organization 1.1027E-4 9 1582 8 6292
    macromolecule metabolic process 1.3953E-4 9 2349 9 6292
    primary metabolic process 9.2081E-4 9 2896 9 6292
    cellular metabolic process 1.3966E-3 9 3033 9 6292
    metabolic process 2.004E-3 9 3157 9 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    transcription cofactor activity 3.6984E-12 9 40 6 6292
    transcription factor binding 5.8668E-12 9 43 6 6292
    transcription regulator activity 1.7138E-6 9 339 6 6292
    protein binding 5.3734E-5 9 612 6 6292
    transcription coactivator activity 3.7663E-4 9 21 2 6292
    TATA-binding protein binding 2.859E-3 9 2 1 6292
    transcription activator activity 3.186E-3 9 61 2 6292
    binding 3.5377E-3 9 1294 6 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle