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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 22 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ATG33
  • mitochondrion
  • biological_process
  • molecular_function
  • BUB1
  • nucleus
  • condensed nuclear chromosome, centromeric region
  • condensed nuclear chromosome kinetochore
  • kinetochore
  • mitotic cell cycle spindle assembly checkpoint
  • protein amino acid phosphorylation
  • protein binding
  • protein kinase activity
  • CUL3
  • nucleus
  • cytoplasm
  • Cul3-RING ubiquitin ligase complex
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • protein binding
  • GUT1
  • cytoplasm
  • glycerol metabolic process
  • glycerol kinase activity
  • ISM1
  • mitochondrion
  • isoleucyl-tRNA aminoacylation
  • translation
  • isoleucine-tRNA ligase activity
  • MEC3
  • nucleus
  • DNA damage checkpoint
  • telomere maintenance via recombination
  • DNA metabolic process
  • chromatin silencing at telomere
  • DNA binding
  • MLC1
  • cellular bud tip
  • cellular bud neck
  • vesicle
  • cytokinesis, actomyosin contractile ring assembly
  • vesicle targeting
  • protein localization
  • cytokinesis
  • myosin II heavy chain binding
  • myosin V binding
  • MYO2
  • incipient cellular bud site
  • cellular bud tip
  • cellular bud neck
  • fungal-type vacuole membrane
  • myosin V complex
  • mating projection tip
  • vesicle
  • filamentous actin
  • mitochondrion inheritance
  • vacuole inheritance
  • establishment of mitotic spindle orientation
  • unidimensional cell growth
  • vesicle-mediated transport
  • Golgi inheritance
  • vesicle transport along actin filament
  • peroxisome inheritance
  • membrane addition at site of cytokinesis
  • budding cell apical bud growth
  • actin filament binding
  • calmodulin binding
  • microfilament motor activity
  • MYO4
  • cellular bud
  • mitochondrion
  • myosin V complex
  • filamentous actin
  • intracellular mRNA localization
  • endoplasmic reticulum inheritance
  • gene conversion at mating-type locus
  • actin filament binding
  • microfilament motor activity
  • RGA1
  • intracellular
  • budding cell isotropic bud growth
  • small GTPase mediated signal transduction
  • pseudohyphal growth
  • actin filament organization
  • invasive growth in response to glucose limitation
  • budding cell apical bud growth
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion
  • Rho GTPase activator activity
  • signal transducer activity
  • RSB1
  • integral to membrane
  • endoplasmic reticulum
  • plasma membrane
  • fatty acid transport
  • phospholipid translocation
  • phospholipid-translocating ATPase activity
  • SAT4
  • cellular_component
  • G1/S transition of mitotic cell cycle
  • cellular cation homeostasis
  • protein kinase activity
  • SHE2
  • cytoplasm
  • intracellular mRNA localization
  • gene conversion at mating-type locus
  • mRNA binding
  • SHE3
  • cytoplasm
  • actin cap
  • intracellular mRNA localization
  • endoplasmic reticulum inheritance
  • gene conversion at mating-type locus
  • mRNA binding
  • SHE4
  • cytoplasm
  • intracellular mRNA localization
  • actin cytoskeleton organization
  • gene conversion at mating-type locus
  • myosin binding
  • SRC1
  • cellular_component
  • mitotic sister chromatid segregation
  • molecular_function
  • SSH4
  • fungal-type vacuole
  • vesicle-mediated transport
  • molecular_function
  • STT4
  • mitochondrion
  • plasma membrane
  • MAPKKK cascade
  • phosphatidylethanolamine biosynthetic process
  • vacuole organization
  • phosphoinositide phosphorylation
  • inositol lipid-mediated signaling
  • protein secretion
  • actin cytoskeleton organization
  • 1-phosphatidylinositol 4-kinase activity
  • TOF2
  • mitochondrion
  • DNA topological change
  • molecular_function
  • TVP18
  • integral to Golgi membrane
  • clathrin-coated vesicle
  • vesicle-mediated transport
  • molecular_function
  • YDR186C
  • cytoplasm
  • ribosome
  • biological_process
  • molecular_function
  • YOL098C
  • cytoplasm
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    myosin V complex 1.1672E-5 22 2 2 6292
    filamentous actin 1.1672E-5 22 2 2 6292
    unconventional myosin complex 1.1672E-5 22 2 2 6292
    myosin complex 3.4941E-5 22 3 2 6292
    actin filament 4.1399E-4 22 9 2 6292
    actin cytoskeleton 3.044E-3 22 85 3 6292
    vesicle 6.2857E-3 22 110 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    intracellular mRNA localization 2.3224E-8 22 10 4 6292
    gene conversion at mating-type locus 3.6411E-8 22 11 4 6292
    mitotic recombination 7.1507E-8 22 33 5 6292
    mating type switching 1.9852E-7 22 16 4 6292
    mating type determination 5.2365E-7 22 20 4 6292
    sex determination 5.2365E-7 22 20 4 6292
    cell fate commitment 9.5049E-7 22 23 4 6292
    endoplasmic reticulum inheritance 1.1672E-5 22 2 2 6292
    DNA recombination 3.6812E-5 22 114 5 6292
    actin filament-based process 4.1728E-5 22 117 5 6292
    vesicle localization 6.9734E-5 22 4 2 6292
    reproduction of a single-celled organism 7.3707E-5 22 217 6 6292
    endoplasmic reticulum organization 1.736E-4 22 6 2 6292
    RNA localization 2.5597E-4 22 92 4 6292
    macromolecule localization 2.8097E-4 22 397 7 6292
    organelle inheritance 4.4788E-4 22 44 3 6292
    budding cell apical bud growth 5.1639E-4 22 10 2 6292
    actin cytoskeleton organization 5.6202E-4 22 113 4 6292
    reproductive cellular process 6.6788E-4 22 211 5 6292
    reproductive process 6.8245E-4 22 212 5 6292
    reproduction 7.0218E-4 22 328 6 6292
    cytoskeleton organization 1.0076E-3 22 231 5 6292
    reproductive process in single-celled organism 1.068E-3 22 134 4 6292
    cell differentiation 1.5454E-3 22 148 4 6292
    localization 1.6185E-3 22 1060 10 6292
    reproductive developmental process 1.6644E-3 22 151 4 6292
    cellular developmental process 2.2287E-3 22 276 5 6292
    organelle organization 2.617E-3 22 1127 10 6292
    isoleucyl-tRNA aminoacylation 3.4965E-3 22 1 1 6292
    Golgi inheritance 3.4965E-3 22 1 1 6292
    cellular localization 4.8729E-3 22 643 7 6292
    developmental process 4.9017E-3 22 331 5 6292
    signal transduction 5.8763E-3 22 214 4 6292
    budding cell bud growth 6.1189E-3 22 34 2 6292
    signal transmission 6.1724E-3 22 217 4 6292
    signaling process 6.1724E-3 22 217 4 6292
    establishment of vesicle localization 6.9813E-3 22 2 1 6292
    developmental growth involved in morphogenesis 6.9813E-3 22 2 1 6292
    vesicle transport along actin filament 6.9813E-3 22 2 1 6292
    actin filament-based movement 6.9813E-3 22 2 1 6292
    developmental growth 6.9813E-3 22 2 1 6292
    unidimensional cell growth 6.9813E-3 22 2 1 6292
    membrane addition at site of cytokinesis 6.9813E-3 22 2 1 6292
    vesicle targeting 6.9813E-3 22 2 1 6292
    cell cycle 7.6876E-3 22 525 6 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytoskeletal protein binding 4.4978E-5 22 59 4 6292
    myosin binding 1.1598E-4 22 5 2 6292
    microfilament motor activity 1.1598E-4 22 5 2 6292
    actin filament binding 7.5417E-4 22 12 2 6292
    motor activity 1.7262E-3 22 18 2 6292
    actin binding 2.3543E-3 22 21 2 6292
    calmodulin binding 3.4965E-3 22 1 1 6292
    myosin heavy chain binding 3.4965E-3 22 1 1 6292
    myosin II heavy chain binding 3.4965E-3 22 1 1 6292
    glycerol kinase activity 3.4965E-3 22 1 1 6292
    myosin V binding 3.4965E-3 22 1 1 6292
    phosphotransferase activity, alcohol group as acceptor 4.458E-3 22 198 4 6292
    mRNA binding 6.4761E-3 22 35 2 6292
    kinase activity 6.6879E-3 22 222 4 6292
    isoleucine-tRNA ligase activity 6.9813E-3 22 2 1 6292
    myosin II binding 6.9813E-3 22 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle