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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 24 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADE2
  • cytoplasm
  • purine nucleotide biosynthetic process
  • 'de novo' IMP biosynthetic process
  • purine base metabolic process
  • phosphoribosylaminoimidazole carboxylase activity
  • BSC2
  • lipid particle
  • biological_process
  • molecular_function
  • CWH41
  • endoplasmic reticulum membrane
  • cellular cell wall organization
  • protein amino acid N-linked glycosylation
  • mannosyl-oligosaccharide glucosidase activity
  • DBF4
  • Dbf4-dependent protein kinase complex
  • DNA replication initiation
  • positive regulation of protein kinase activity
  • DNA replication origin binding
  • protein serine/threonine kinase activator activity
  • DIG1
  • nucleus
  • telomere maintenance
  • invasive growth in response to glucose limitation
  • DNA binding
  • transcription factor binding
  • ECM29
  • nucleus
  • cytoplasm
  • proteasome complex
  • protein catabolic process
  • protein binding
  • HAL5
  • cellular_component
  • cellular cation homeostasis
  • protein kinase activity
  • LAA1
  • AP-1 adaptor complex
  • ribosome
  • clathrin-coated vesicle
  • protein localization
  • retrograde transport, endosome to Golgi
  • molecular_function
  • MRC1
  • replication fork
  • nucleus
  • nuclear chromosome
  • DNA replication checkpoint
  • telomere maintenance
  • chromatin silencing at silent mating-type cassette
  • chromatin silencing at telomere
  • molecular_function
  • OPI9
    PEX32
  • integral to peroxisomal membrane
  • peroxisome organization
  • molecular_function
  • PRP5
  • spliceosomal complex
  • RNA splicing
  • nuclear mRNA branch site recognition
  • mRNA processing
  • ATP-dependent RNA helicase activity
  • PTH2
  • cytoplasm
  • mitochondrion
  • mitochondrial outer membrane
  • translation
  • negative regulation of proteasomal ubiquitin-dependent protein catabolic process
  • aminoacyl-tRNA hydrolase activity
  • RGA2
  • intracellular
  • budding cell isotropic bud growth
  • small GTPase mediated signal transduction
  • pseudohyphal growth
  • actin filament organization
  • invasive growth in response to glucose limitation
  • budding cell apical bud growth
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion
  • Rho GTPase activator activity
  • signal transducer activity
  • RMA1
  • mitochondrion
  • biological_process
  • tetrahydrofolylpolyglutamate synthase activity
  • RPN3
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • SIR1
  • chromatin silencing complex
  • establishment of chromatin silencing
  • chromatin silencing at silent mating-type cassette
  • DNA binding
  • chromatin binding
  • STE12
  • nucleus
  • positive regulation of transcription from RNA polymerase II promoter by pheromones
  • conjugation with cellular fusion
  • pseudohyphal growth
  • invasive growth in response to glucose limitation
  • transcription factor activity
  • THR1
  • cellular_component
  • isoleucine metabolic process
  • homoserine metabolic process
  • methionine metabolic process
  • threonine metabolic process
  • homoserine kinase activity
  • TLG2
  • early endosome
  • trans-Golgi network
  • Golgi trans cisterna
  • vesicle fusion
  • receptor signaling protein serine/threonine kinase activity
  • VPS45
  • cytosol
  • Golgi membrane
  • extrinsic to membrane
  • protein complex assembly
  • vacuole organization
  • Golgi to vacuole transport
  • unfolded protein binding
  • YDL199C
  • cellular_component
  • biological_process
  • molecular_function
  • YEL057C
  • cellular_component
  • telomere maintenance
  • molecular_function
  • YPL035C

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    Dbf4-dependent protein kinase complex 7.6148E-3 24 2 1 6292
    Golgi apparatus part 9.9927E-3 24 119 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    invasive growth in response to glucose limitation 7.0835E-4 24 47 3 6292
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process 3.8144E-3 24 1 1 6292
    negative regulation of cellular catabolic process 3.8144E-3 24 1 1 6292
    filamentous growth of a population of unicellular organisms 4.609E-3 24 90 3 6292
    growth of unicellular organism as a thread of attached cells 4.609E-3 24 90 3 6292
    DNA replication initiation 6.8504E-3 24 33 2 6292
    chromatin silencing at silent mating-type cassette 6.8504E-3 24 33 2 6292
    filamentous growth 7.2724E-3 24 106 3 6292
    negative regulation of catabolic process 7.6148E-3 24 2 1 6292
    negative regulation of protein catabolic process 7.6148E-3 24 2 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    homoserine kinase activity 3.8144E-3 24 1 1 6292
    phosphoribosylaminoimidazole carboxylase activity 3.8144E-3 24 1 1 6292
    mannosyl-oligosaccharide glucosidase activity 3.8144E-3 24 1 1 6292
    aminoacyl-tRNA hydrolase activity 7.6148E-3 24 2 1 6292
    protein serine/threonine kinase activator activity 7.6148E-3 24 2 1 6292
    tetrahydrofolylpolyglutamate synthase activity 7.6148E-3 24 2 1 6292

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