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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 14 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • IPI3
  • nucleus
  • nuclear outer membrane
  • nucleoplasm
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • MRT4
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • telomere maintenance
  • ribosome biogenesis
  • rRNA processing
  • mRNA catabolic process
  • molecular_function
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP15
  • nucleus
  • nucleolus
  • cytokinesis, actomyosin contractile ring assembly
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NSA2
  • nucleus
  • preribosome, large subunit precursor
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • RIX1
  • nucleus
  • nuclear outer membrane
  • nucleoplasm
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • RLP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • RPF1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • rRNA primary transcript binding
  • SDA1
  • nucleus
  • ribosome biogenesis
  • traversing start control point of mitotic cell cycle
  • ribosome assembly
  • actin cytoskeleton organization
  • molecular_function
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 1.2977E-12 14 211 10 6292
    nuclear lumen 1.3468E-12 14 453 12 6292
    organelle lumen 1.208E-10 14 660 12 6292
    intracellular organelle lumen 1.208E-10 14 660 12 6292
    membrane-enclosed lumen 2.4297E-10 14 700 12 6292
    nuclear part 5.1432E-8 14 1103 12 6292
    nucleus 1.3856E-7 14 2041 14 6292
    nuclear outer membrane 7.7115E-7 14 86 5 6292
    nuclear membrane 1.4082E-6 14 97 5 6292
    non-membrane-bounded organelle 3.608E-6 14 959 10 6292
    intracellular non-membrane-bounded organelle 3.608E-6 14 959 10 6292
    outer membrane 2.7876E-5 14 178 5 6292
    organelle outer membrane 2.7876E-5 14 178 5 6292
    nuclear envelope 4.7744E-5 14 199 5 6292
    nuclear membrane-endoplasmic reticulum network 9.9488E-5 14 232 5 6292
    preribosome, large subunit precursor 1.6406E-4 14 9 2 6292
    organelle part 2.0575E-4 14 2282 12 6292
    intracellular organelle part 2.0575E-4 14 2282 12 6292
    membrane-bounded organelle 7.6409E-4 14 3771 14 6292
    intracellular membrane-bounded organelle 7.6409E-4 14 3771 14 6292
    endomembrane system 1.227E-3 14 398 5 6292
    intracellular organelle 2.2276E-3 14 4070 14 6292
    organelle 2.2353E-3 14 4071 14 6292
    preribosome 2.4766E-3 14 34 2 6292
    envelope 3.5497E-3 14 505 5 6292
    organelle envelope 3.5497E-3 14 505 5 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosomal large subunit biogenesis 4.5368E-23 14 65 12 6292
    ribosome biogenesis 1.7971E-18 14 346 14 6292
    ribonucleoprotein complex biogenesis 5.4511E-18 14 374 14 6292
    cellular component biogenesis 3.5072E-14 14 694 14 6292
    ribosome assembly 2.4576E-9 14 64 6 6292
    organelle assembly 3.908E-9 14 69 6 6292
    ribonucleoprotein complex assembly 2.2665E-8 14 92 6 6292
    processing of 27S pre-rRNA 2.75E-8 14 16 4 6292
    cellular macromolecular complex assembly 1.3361E-6 14 182 6 6292
    ribosomal large subunit assembly 1.4822E-6 14 41 4 6292
    ribosomal subunit assembly 4.9032E-6 14 55 4 6292
    obsolete_biological_process 6.9658E-6 14 60 4 6292
    cellular macromolecular complex subunit organization 1.0438E-5 14 259 6 6292
    macromolecular complex assembly 1.6684E-5 14 281 6 6292
    establishment of ribosome localization 2.2128E-5 14 26 3 6292
    ribosome localization 2.2128E-5 14 26 3 6292
    ribosomal subunit export from nucleus 2.2128E-5 14 26 3 6292
    macromolecular complex subunit organization 6.5117E-5 14 357 6 6292
    cellular component assembly 9.9527E-5 14 385 6 6292
    establishment of organelle localization 2.1493E-4 14 55 3 6292
    organelle localization 7.7786E-4 14 85 3 6292
    nuclear export 1.3601E-3 14 103 3 6292
    rRNA processing 2.5404E-3 14 128 3 6292
    nuclear transport 2.6553E-3 14 130 3 6292
    nucleocytoplasmic transport 2.6553E-3 14 130 3 6292
    rRNA metabolic process 3.0829E-3 14 137 3 6292
    organelle organization 6.1726E-3 14 1127 7 6292
    actomyosin structure organization 6.6614E-3 14 3 1 6292
    cytokinesis, actomyosin contractile ring assembly 6.6614E-3 14 3 1 6292
    assembly of actomyosin apparatus involved in cell cycle cytokinesis 6.6614E-3 14 3 1 6292
    cellular process 7.2188E-3 14 4426 14 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    rRNA binding 5.4201E-4 14 16 2 6292
    ribosomal large subunit binding 2.225E-3 14 1 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle