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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 14 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
    		•
  • ATP-dependent RNA helicase activity
    		•
    CLF1
  • chromatin
    		•
  • DNA replication
  • cell cycle
  • cis assembly of pre-catalytic spliceosome
  • nuclear mRNA splicing, via spliceosome
    		•
  • protein binding
    		•
    HSH155
  • U2 snRNP
    		•
  • spliceosome assembly
    		•
  • mRNA binding
    		•
    LEA1
  • cytoplasm
  • U2 snRNP
    		•
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
  • molecular_function
    		•
    PRP19
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
    		•
  • nuclear mRNA splicing, via spliceosome
  • ubiquitin-dependent protein catabolic process
    		•
  • ubiquitin-protein ligase activity
  • first spliceosomal transesterification activity
  • RNA binding
    		•
    PRP46
  • spliceosomal complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • molecular_function
    		•
    PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
    		•
  • U5 snRNA binding
    		•
    PRP9
  • U2 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
    		•
    RSE1
  • U2 snRNP
    		•
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
    		•
  • U2 snRNA binding
    		•
    SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
  • molecular_function
    		•
    SNT309
  • spliceosomal complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • protein binding
    		•
    SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
    		•
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
    		•
    SPP382
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
    		•
    STO1
  • commitment complex
  • nuclear cap binding complex
    		•
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
    		•
  • mRNA binding
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    ribonucleoprotein complex 8.1265E-14 14 514 13 6292
    small nuclear ribonucleoprotein complex 1.8297E-13 14 63 8 6292
    nuclear part 1.6352E-9 14 1103 13 6292
    U2 snRNP 1.0845E-8 14 13 4 6292
    U5 snRNP 1.5164E-8 14 14 4 6292
    spliceosomal complex 2.8418E-8 14 45 5 6292
    macromolecular complex 2.5299E-7 14 1635 13 6292
    U4/U6 x U5 tri-snRNP complex 5.3239E-7 14 32 4 6292
    organelle part 6.6422E-7 14 2282 14 6292
    intracellular organelle part 6.6422E-7 14 2282 14 6292
    nucleus 4.2048E-6 14 2041 13 6292
    intracellular organelle 2.2276E-3 14 4070 14 6292
    organelle 2.2353E-3 14 4071 14 6292
    nuclear cap binding complex 6.6614E-3 14 3 1 6292
    membrane-bounded organelle 7.9402E-3 14 3771 13 6292
    intracellular membrane-bounded organelle 7.9402E-3 14 3771 13 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    nuclear mRNA splicing, via spliceosome 2.2052E-26 14 99 14 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 2.5642E-26 14 100 14 6292
    RNA splicing, via transesterification reactions 7.0578E-26 14 107 14 6292
    RNA splicing 1.589E-24 14 132 14 6292
    mRNA processing 1.8451E-23 14 156 14 6292
    mRNA metabolic process 1.702E-21 14 213 14 6292
    RNA processing 6.8385E-18 14 380 14 6292
    RNA metabolic process 3.1282E-12 14 954 14 6292
    gene expression 2.03E-10 14 1283 14 6292
    nucleic acid metabolic process 8.0503E-10 14 1415 14 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.3498E-9 14 1566 14 6292
    cellular nitrogen compound metabolic process 1.8728E-8 14 1770 14 6292
    nitrogen compound metabolic process 2.2103E-8 14 1791 14 6292
    ribonucleoprotein complex assembly 2.2665E-8 14 92 6 6292
    spliceosome assembly 4.6119E-8 14 18 4 6292
    cellular macromolecule metabolic process 6.7658E-7 14 2285 14 6292
    macromolecule metabolic process 9.9712E-7 14 2349 14 6292
    cellular macromolecular complex assembly 1.3361E-6 14 182 6 6292
    cellular macromolecular complex subunit organization 1.0438E-5 14 259 6 6292
    macromolecular complex assembly 1.6684E-5 14 281 6 6292
    primary metabolic process 1.8826E-5 14 2896 14 6292
    cellular metabolic process 3.6009E-5 14 3033 14 6292
    metabolic process 6.3176E-5 14 3157 14 6292
    macromolecular complex subunit organization 6.5117E-5 14 357 6 6292
    ribonucleoprotein complex biogenesis 8.4596E-5 14 374 6 6292
    cellular component assembly 9.9527E-5 14 385 6 6292
    spliceosomal conformational changes to generate catalytic conformation 1.6406E-4 14 9 2 6292
    regulation of hormone levels 2.225E-3 14 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 2.225E-3 14 1 1 6292
    auxin biosynthetic process 2.225E-3 14 1 1 6292
    auxin metabolic process 2.225E-3 14 1 1 6292
    hormone metabolic process 2.225E-3 14 1 1 6292
    hormone biosynthetic process 2.225E-3 14 1 1 6292
    cellular component biogenesis 2.4266E-3 14 694 6 6292
    nuclear mRNA 3'-splice site recognition 4.4455E-3 14 2 1 6292
    cis assembly of pre-catalytic spliceosome 4.4455E-3 14 2 1 6292
    nuclear mRNA cis splicing, via spliceosome 6.6614E-3 14 3 1 6292
    generation of catalytic spliceosome for first transesterification step 6.6614E-3 14 3 1 6292
    cellular process 7.2188E-3 14 4426 14 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA binding 3.2847E-10 14 367 10 6292
    snRNA binding 8.7489E-8 14 5 3 6292
    nucleic acid binding 1.1164E-7 14 666 10 6292
    binding 3.2953E-7 14 1294 12 6292
    U5 snRNA binding 4.5979E-6 14 2 2 6292
    U2 snRNA binding 2.225E-3 14 1 1 6292
    mRNA binding 2.6233E-3 14 35 2 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle