Protein Overview: CAB1

General Information:
Name(s) found:	CAB1 / YDR531W [SGD]
Description(s) found: Found 28 descriptions. SHOW ALL	Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA) [SGD]
Organism:	Saccharomyces cerevisiae
Length:	367 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	coenzyme A biosynthetic process [ISS]
Molecular Function:	pantothenate kinase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRITQEISY NCDYGDNTFN LAIDIGGTLA KVVFSPIHSN RLMFYTIETE KIDKFMELLH  60
   61 SIIKEHNNGC YRMTHIIATG GGAFKFYDLL YENFPQIKGI SRFEEMEGLI HGLDFFIHEI 120
  121 PDEVFTYNDQ DGERIIPTSS GTMDSKAIYP YLLVNIGSGV SILKVTEPNN FSRVGGSSLG 180
  181 GGTLWGLLSL ITGAQTYDQM LDWAQEGDNS SVDMLVGDIY GTDYNKIGLK SSAIASSFGK 240
  241 VFQNRMTSNK SLENNENKLY SSHESIEKNN GQMFKNPDIC KSLLFAISNN IGQIAYLQAK 300
  301 INNIQNIYFG GSYTRGHLTT MNTLSYAINF WSQGSKQAFF LKHEGYLGAM GAFLSASRHS 360
  361 STKKTST

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CAB1	No Comments	Hazbun TR, et al. (2003)
View Run	CAB1	No Comments	Hazbun TR, et al. (2003)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CAB1	CTH1	2	Hazbun TR, et al. (2003)
View Screen	CAB1	CAB1	2	Hazbun TR, et al. (2003)
View Screen	CAB1	RPL43B, RPL43A	2	Hazbun TR, et al. (2003)

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	CAB1 and SPC42	Hazbun TR, et al. (2003)
View Data	CAB1	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..367]	Pfam	221.568636	Fumble No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
pantothenate kinase activity	1.44039088435404	bayes_pls_golite062009
binding	1.42470807327213	bayes_pls_golite062009
carbohydrate kinase activity	1.3713660758447	bayes_pls_golite062009
kinase activity	0.90616568759573	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.797242642077629	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.59082563232385	bayes_pls_golite062009
hexokinase activity	0.49038289556657	bayes_pls_golite062009
hydrolase activity	0.439984937787325	bayes_pls_golite062009
catalytic activity	0.296484721581333	bayes_pls_golite062009
transferase activity	0.105619024604158	bayes_pls_golite062009
nucleic acid binding	0.101675282305395	bayes_pls_golite062009
unfolded protein binding	0.0304569608189402	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.75

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2