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Protein Overview: ALG14

General Information:
Name(s) found: ALG14 / YBR070C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 237 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    nuclear membrane-endoplasmic reticulum network [IDALink to PubMed article]
    integral to endoplasmic reticulum membrane [IDALink to PubMed article]
    UDP-N-acetylglucosamine transferase complex [IPILink to PubMed articleLink to PubMed article]
    Biological Process: dolichol-linked oligosaccharide biosynthetic process [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed article][ISSLink to PubMed articleLink to PubMed article]
    Molecular Function: protein anchor [IMPLink to PubMed articleLink to PubMed article]
    N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed article][ISSLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTAYLASLV LIVSTAYVIR LIAILPFFHT QAGTEKDTKD GVNLLKIRKS SKKPLKIFVF  60
   61 LGSGGHTGEM IRLLENYQDL LLGKSIVYLG YSDEASRQRF AHFIKKFGHC KVKYYEFMKA 120
  121 REVKATLLQS VKTIIGTLVQ SFVHVVRIRF AMCGSPHLFL LNGPGTCCII SFWLKIMELL 180
  181 LPLLGSSHIV YVESLARINT PSLTGKILYW VVDEFIVQWQ ELRDNYLPRS KWFGILV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ALG13 ALG14

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ALG13 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ALG14 Sundin BA, et al. (2004)
    View Data ALG14 Sundin BA, et al. (2004)
    View Data ALG14 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..237] ORFEUS 8.21 Peptidoglycan biosynthesys glycosyltransferase MurG


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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