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Protein Overview: ATXN1

General Information:
Name(s) found: ATXN1 [HGNC (HUGO)]
Description(s) found:
Found 21 descriptions.
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  • ataxin 1 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 815 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSNQERSNE CLPPKKREIP ATSRSSEEKA PTLPSDNHRV EGTAWLPGNP GGRGHGGGRH  60
   61 GPAGTSVELG LQQGIGLHKA LSTGLDYSPP SAPRSVPVAT TLPAAYATPQ PGTPVSPVQY 120
  121 AHLPHTFQFI GSSQYSGTYA SFIPSQLIPP TANPVTSAVA SAAGATTPSQ RSQLEAYSTL 180
  181 LANMGSLSQT PGHKAEQQQQ QQQQQQQQHQ HQQQQQQQQQ QQQQQHLSRA PGLITPGSPP 240
  241 PAQQNQYVHI SSSPQNTGRT ASPPAIPVHL HPHQTMIPHT LTLGPPSQVV MQYADSGSHF 300
  301 VPREATKKAE SSRLQQAIQA KEVLNGEMEK SRRYGAPSSA DLGLGKAGGK SVPHPYESRH 360
  361 VVVHPSPSDY SSRDPSGVRA SVMVLPNSNT PAADLEVQQA THREASPSTL NDKSGLHLGK 420
  421 PGHRSYALSP HTVIQTTHSA SEPLPVGLPA TAFYAGTQPP VIGYLSGQQQ AITYAGSLPQ 480
  481 HLVIPGTQPL LIPVGSTDME ASGAAPAIVT SSPQFAAVPH TFVTTALPKS ENFNPEALVT 540
  541 QAAYPAMVQA QIHLPVVQSV ASPAAAPPTL PPYFMKGSII QLANGELKKV EDLKTEDFIQ 600
  601 SAEISNDLKI DSSTVERIED SHSPGVAVIQ FAVGEHRAQV SVEVLVEYPF FVFGQGWSSC 660
  661 CPERTSQLFD LPCSKLSVGD VCISLTLKNL KNGSVKKGQP VDPASVLLKH SKADGLAGSR 720
  721 HRYAEQENGI NQGSAQMLSE NGELKFPEKM GLPAAPFLTK IEPSKPAATR KRRWSAPESR 780
  781 KLEKSEDEPP LTLPKPSLIP QEVKICIEGR SNVGK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..218] MSA 1.209995 View MSA. No confident structure predictions are available.
    2 View Details [219..274] deduced N/A No confident structure predictions are available.
    3 View Details [275..429] MSA 4.22299 View MSA. No confident structure predictions are available.
    4 View Details [430..567] MSA 1.194996 View MSA. No confident structure predictions are available.
    5 View Details [568..693] PSI-BLAST 67.0 AXH domain of human spinocerebellar ataxin-1
    6 View Details [694..815] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • poly(G) RNA binding
    		•  9.63713595128054 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.87938017809999 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.44900037030135 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.11421838242937 bayes_pls_golite062009
  • RNA binding
    		•  2.52330994423305 bayes_pls_golite062009
  • binding
    		•  2.24516466558786 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  2.14262126704047 bayes_pls_golite062009
  • protein binding
    		•  1.94841008133032 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  1.45078449963459 bayes_pls_golite062009
  • poly-purine tract binding
    		•  1.22216556549636 bayes_pls_golite062009
  • protein self-association
    		•  1.12839499794765 bayes_pls_golite062009
  • poly(U) RNA binding
    		•  0.844689081318551 bayes_pls_golite062009
  • identical protein binding
    		•  0.651473260854041 bayes_pls_golite062009
  • protein C-terminus binding
    		•  0.163823997825061 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle