Protein Overview: l(2)k01209-PA

General Information:
Name(s) found:	l(2)k01209-PA / FBpp0086068 [FlyBase]
Description(s) found: Found 19 descriptions. SHOW ALL	The gene lethal (2) k01209 is referred to in FlyBase by the symbol Dmel\l(2)k01209 (CG4798, FBgn0022029). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13307938..13313192. It has the cytological map location 54B7. Based on sequence similarity, it is predicted to have molecular function</span>: uridine kinase activity. The biological processes in which it is involved are not known. 14 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	561 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	metabolic process [IEA]
Molecular Function:	ATP binding [IEA] uridine kinase activity [ISS] phosphotransferase activity, alcohol group as acceptor [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVTQTKQIK FYNPSSSASS DSDDRSLSDV TEQLYVDPYA DLSNGLPGDL NCCPASPTTV  60
   61 PAKASLDSPL KRSGRRQRTT SIGNQTTTAN PSECIIRANN RTIYTAGRPP WYNCAGQQVE 120
  121 PFVIGICGGS ASGKTTVAEK IIESLDVPWV TLLSMDCFYK ILNEKQHEQA LINEYNFDHP 180
  181 DAFDIELLLD VLTKLKEGRK VEVPVYNFVT HGRESQTKTM YGANVIIFEG ILTFHSPEVL 240
  241 KLLDMKIFVD TDPDIRLARR LRRDISQRGR DLKGVLKQYL NMVKPSYCNY IAPTMAHADI 300
  301 IVPRGGDNKV AIHLIVQHVH TQLQLRGFKL RETLANSYKD QPMPHSLHLL HPTPQIKGLH 360
  361 TFIRCRNTSR DEFIFYSKRL IRLVIEYALS LFPFKKTTVE TPQGVLYEGK RMESRKICGV 420
  421 SILRAGETME QAVCDVCKDI RIGKILIQTN LKTGEPELYY LRLPKDIKDY KVILMDATVA 480
  481 TGAAAMMAIR VLLDHDVPED NIILASLLMA EIGVHSIAYA FPKVKIVTSA LDPEINSKFY 540
  541 VIPGIGNFGD RYFGTEPSDE Y

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..293]	PSI-BLAST	44.522879	Pantothenate kinase PanK
2	View Details	[294..343]	PSI-BLAST	42.69897	Rapid structure determination of human uridine-cytidine kinase 2 using a conventional laboratory X-ray source and a single samarium derivative
3	View Details	[344..561]	PSI-BLAST	51.154902	Uracil PRTase

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
nucleobase, nucleoside, nucleotide kinase activity	3.66392587433723	bayes_pls_golite062009
nucleotide kinase activity	2.24094813695083	bayes_pls_golite062009
binding	2.20860426568814	bayes_pls_golite062009
kinase activity	2.0779386406753	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	1.96697952975573	bayes_pls_golite062009
nucleic acid binding	1.08697924060619	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
DNA binding	0.702147676354075	bayes_pls_golite062009
adenylate kinase activity	0.447752711852745	bayes_pls_golite062009
transcription regulator activity	0.287777990975748	bayes_pls_golite062009
protein binding	0.193768631623192	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009
nucleotide binding	0.0593371872166591	bayes_pls_golite062009
purine nucleotide binding	0.0285347443435678	bayes_pls_golite062009

2

No functions predicted.

3

Term	Confidence	Notes
uracil phosphoribosyltransferase activity	3.97944228585882	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	3.91023158228049	bayes_pls_golite062009
adenine phosphoribosyltransferase activity	3.07502596276449	bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity	2.97347277288245	bayes_pls_golite062009
transferase activity	2.73727660668741	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	2.53679639481311	bayes_pls_golite062009
catalytic activity	2.30431811394775	bayes_pls_golite062009
nucleobase binding	1.70525606708275	bayes_pls_golite062009
purine binding	1.24786927434743	bayes_pls_golite062009
ribose phosphate diphosphokinase activity	0.947697983706416	bayes_pls_golite062009
binding	0.847513071499147	bayes_pls_golite062009
diphosphotransferase activity	0.749909396904601	bayes_pls_golite062009
nucleic acid binding	0.552133387792911	bayes_pls_golite062009
DNA binding	0.439741935655503	bayes_pls_golite062009
transcription regulator activity	0.396538943915776	bayes_pls_golite062009
amidophosphoribosyltransferase activity	0.360901350940423	bayes_pls_golite062009
orotate phosphoribosyltransferase activity	0.148898393751978	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.84

Source: Reynolds et al. (2008)

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