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Protein Overview: par-1-PG

General Information:
Name(s) found: par-1-PG / FBpp0085652 [FlyBase]
Description(s) found:
Found 11 descriptions.
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  • The gene par-1 is referred to in FlyBase by the symbol Dmel\par-1 (CG8201, FBgn0260934). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15343679..15371978. It has the cytological map location 56D9-57D12. There is experimental evidence that it has the molecular function</span>: tau-protein kinase activity; protein kinase activity. There is experimental evidence for 14 unique biological process</span> terms, many of which group under: reproductive process in a multicellular organism; organelle organization; ovarian follicle cell development; regulation of developmental process; multicellular organism reproduction; regulation of cell morphogenesis; oocyte axis specification; regulation of cellular component organization; microtubule cytoskeleton organization; immune response; actin filament-based process; delamination. 59 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; external compound sense organ; peripheral nervous system; female germline cyst; cuticle; abdominal ventral denticle belt; nervous system; compound cell cluster organ; blastoderm embryo; abdominal 5 ventral denticle belt; embryonic segment. It has 19 annotated transcripts and 19 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1138 amino acids

    Gene Ontology:
    Cellular Component: germline ring canal [IDA]
    cell cortex [IDA]
    fusome [IDA]
    basolateral plasma membrane [IDA]
    Biological Process: regulation of cell shape [IMP]
    germarium-derived oocyte fate determination [IMP][TAS]
    axis specification [IMP]
    border follicle cell delamination [IMP]
    actin filament organization [IMP]
    gamete generation [IMP]
    border follicle cell migration [IMP]
    oocyte differentiation [TAS]
    microtubule cytoskeleton organization [IMP]
    protein amino acid phosphorylation [ISS][NAS]
    oocyte anterior/posterior axis specification [TAS]
    anterior/posterior axis specification [TAS]
    maintenance of protein location [TAS]
    regulation of pole plasm oskar mRNA localization [IMP]
    pole plasm protein localization [IMP]
    oocyte nucleus localization involved in oocyte dorsal/ventral axis specification [IMP]
    ovarian follicle cell development [IMP]
    pole plasm oskar mRNA localization [TAS]
    regulation of Wnt receptor signaling pathway [TAS]
    antimicrobial humoral response [IMP]
    oocyte microtubule cytoskeleton organization [IMP][TAS]
    Molecular Function: tau-protein kinase activity [IDA]
    ATP binding [IEA]
    protein kinase activity [IDA]
    protein serine/threonine kinase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEATTTTTPD LNRGDATRKS VRLYAARKGA APAPPKLSVA PSSNQNSNHS SNNNNSSSNL  60
   61 PETEKEMELR QTHLANKDLD GATEDDSIVE LRRRDAQATP LPRIAVSALP TLQPHPTPKE 120
  121 RQKPPMPRLL STEDDAGVSF ALGSIEKHIH NVEESFKQQQ QNQQSQSSMD VMKLEIKRKQ 180
  181 SKRYGETENL LRPGISDMSS ENDFQYLGGR RAGELDDSNE LMLSEFQRGS DGRNSIGAYS 240
  241 KNSAAAANGA NAVKAKLART ASDTKNNDTV LAMRATFKQK QHLQDEKQPA VWRPAGTGPT 300
  301 PAARSSSSTT STSGSASRGG SSSSVVDGVA PSKLTATTIS ASKRREENLR QFEALLAQKS 360
  361 SHRHGASGAS GTGSNAASSK RRSDRPIVAP IPPYNSSRAE HVTSSTRHSV DPRSHSGHES 420
  421 RSGTASTHPP VGHHPTSRVP SVVANRSNVY SNNAAQGSPN MQMRSSAPMR WRATEEHIGK 480
  481 YKLIKTIGKG NFAKVKLAKH LPTGKEVAIK IIDKTQLNPG SLQKLFREVR IMKMLDHPNI 540
  541 VKLFQVIETE KTLYLIMEYA SGGEVFDYLV LHGRMKEKEA RVKFRQIVSA VQYCHQKRII 600
  601 HRDLKAENLL LDSELNIKIA DFGFSNEFTP GSKLDTFCGS PPYAAPELFQ GKKYDGPEVD 660
  661 VWSLGVILYT LVSGSLPFDG STLRELRERV LRGKYRIPFY MSTDCENLLR KFLVLNPAKR 720
  721 ASLETIMGDK WMNMGFEEDE LKPYIEPKAD LADPKRIEAL VAMGYNRSEI EASLSQVRYD 780
  781 DVFATYLLLG RKSTDPESDG SRSGSSLSLR NISGNDAGAN AGSASVQSPT HRGVHRSISA 840
  841 SSTKPSRRAS SGAETLRVGP TNAAATVAAA TGAVGAVNPS NNYNAAGSAA DRASVGSNFK 900
  901 RQNTIDSATI KENTARLAAQ NQRPASATQK MLTTADTTLN SPAKPRTATK YDPTNGNRTV 960
  961 SGTSGIIPRR STTLYEKTSS TEKTNVIPAE TKARNNTALE YSGTSGASGD SSHPGRMSFF1020
 1021 SKLSSRFSKR PTIADEAAKP RVLRFTWSMK TTSPLMPDQI MQKIREVLDQ NNCDYEQRER1080
 1081 FVLWCVHGDP NTDSLVQWEI EVCKLPRLSL NGVRFKRISG TSIGFKNIAS RIAFDLKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..208] deduced N/A No confident structure predictions are available.
    2 View Details [209..363] deduced N/A No confident structure predictions are available.
    3 View Details [364..744] PSI-BLAST 45.221849 No description for 2ozoA was found.
    4 View Details [745..829] PSI-BLAST 100.0 No description for 2qnjA was found.
    5 View Details [830..1053] deduced N/A No confident structure predictions are available.
    6 View Details [1054..1138] PSI-BLAST 38.0 Solution structure of kinase associated domain 1 of mouse MAP/microtubule affinity-regulating kinase 3

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • protein kinase activity
    		•  4.05475891009228 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  3.7974128326421 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  3.59230737331367 bayes_pls_golite062009
  • kinase activity
    		•  3.41737435609334 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  3.2342722637405 bayes_pls_golite062009
  • binding
    		•  2.41732321506551 bayes_pls_golite062009
  • transferase activity
    		•  2.04713540681686 bayes_pls_golite062009
  • ATP binding
    		•  1.44435058039859 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.41005152726625 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.38971642420542 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.16863558166547 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.16859376715941 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.15633908642115 bayes_pls_golite062009
  • nucleotide binding
    		•  1.14964488472581 bayes_pls_golite062009
  • AMP-activated protein kinase activity
    		•  1.12923456567012 bayes_pls_golite062009
  • catalytic activity
    		•  0.836142537655721 bayes_pls_golite062009
  • protein binding
    		•  0.704339182896017 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.439688030503848 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle